FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114443206> ?p ?o ?g. }

• W2114443206 endingPage "1557" @default.
• W2114443206 startingPage "1546" @default.
• W2114443206 abstract "Promoters are central to the regulation of gene expression. Changes in gene regulation are thought to underlie much of the adaptive diversification between species and phenotypic variation within populations. In contrast to earlier work emphasizing the importance of enhancer evolution and subtle sequence changes at promoters, we show that dramatic changes such as the complete gain and loss (collectively, turnover) of functional promoters are common. Using quantitative measures of transcription initiation in both humans and mice across 52 matched tissues, we discriminate promoter sequence gains from losses and resolve the lineage of changes. We also identify expression divergence and functional turnover between orthologous promoters, finding only the latter is associated with local sequence changes. Promoter turnover has occurred at the majority (>56%) of protein-coding genes since humans and mice diverged. Tissue-restricted promoters are the most evolutionarily volatile where retrotransposition is an important, but not the sole, source of innovation. There is considerable heterogeneity of turnover rates between promoters in different tissues, but the consistency of these in both lineages suggests that the same biological systems are similarly inclined to transcriptional rewiring. The genes affected by promoter turnover show evidence of adaptive evolution. In mice, promoters are primarily lost through deletion of the promoter containing sequence, whereas in humans, many promoters appear to be gradually decaying with weak transcriptional output and relaxed selective constraint. Our results suggest that promoter gain and loss is an important process in the evolutionary rewiring of gene regulation and may be a significant source of phenotypic diversification." @default.
• W2114443206 created "2016-06-24" @default.
• W2114443206 creator A5008886339 @default.
• W2114443206 creator A5026910430 @default.
• W2114443206 creator A5032097008 @default.
• W2114443206 creator A5051284054 @default.
• W2114443206 creator A5065938896 @default.
• W2114443206 creator A5066046411 @default.
• W2114443206 creator A5066740737 @default.
• W2114443206 creator A5072131150 @default.
• W2114443206 creator A5075290044 @default.
• W2114443206 creator A5076700359 @default.
• W2114443206 creator A5087439948 @default.
• W2114443206 date "2015-07-30" @default.
• W2114443206 modified "2023-10-17" @default.
• W2114443206 title "The frequent evolutionary birth and death of functional promoters in mouse and human" @default.
• W2114443206 cites W1863031986 @default.
• W2114443206 cites W1975635514 @default.
• W2114443206 cites W1978083828 @default.
• W2114443206 cites W1983275320 @default.
• W2114443206 cites W1986223165 @default.
• W2114443206 cites W1987157677 @default.
• W2114443206 cites W1988871238 @default.
• W2114443206 cites W1990139627 @default.
• W2114443206 cites W1991036278 @default.
• W2114443206 cites W1991543373 @default.
• W2114443206 cites W1997423398 @default.
• W2114443206 cites W1999013260 @default.
• W2114443206 cites W2000609514 @default.
• W2114443206 cites W2010746507 @default.
• W2114443206 cites W2014279841 @default.
• W2114443206 cites W2019462186 @default.
• W2114443206 cites W2031459252 @default.
• W2114443206 cites W2033201031 @default.
• W2114443206 cites W2033831809 @default.
• W2114443206 cites W2038473742 @default.
• W2114443206 cites W2038584294 @default.
• W2114443206 cites W2041186704 @default.
• W2114443206 cites W2047285578 @default.
• W2114443206 cites W2055143633 @default.
• W2114443206 cites W2057692691 @default.
• W2114443206 cites W2059805279 @default.
• W2114443206 cites W2065103652 @default.
• W2114443206 cites W2066261076 @default.
• W2114443206 cites W2069298307 @default.
• W2114443206 cites W2077072527 @default.
• W2114443206 cites W2081719540 @default.
• W2114443206 cites W2088990426 @default.
• W2114443206 cites W2090803844 @default.
• W2114443206 cites W2095903180 @default.
• W2114443206 cites W2099468911 @default.
• W2114443206 cites W2100573531 @default.
• W2114443206 cites W2109521571 @default.
• W2114443206 cites W2111733032 @default.
• W2114443206 cites W2111921000 @default.
• W2114443206 cites W2115031948 @default.
• W2114443206 cites W2115379981 @default.
• W2114443206 cites W2116254364 @default.
• W2114443206 cites W2118852675 @default.
• W2114443206 cites W2121895515 @default.
• W2114443206 cites W2122452605 @default.
• W2114443206 cites W2128016314 @default.
• W2114443206 cites W2128969076 @default.
• W2114443206 cites W2131487299 @default.
• W2114443206 cites W2141286013 @default.
• W2114443206 cites W2141991780 @default.
• W2114443206 cites W2154770881 @default.
• W2114443206 cites W2155761693 @default.
• W2114443206 cites W2160682089 @default.
• W2114443206 cites W2160714946 @default.
• W2114443206 cites W2160953907 @default.
• W2114443206 cites W2161566669 @default.
• W2114443206 cites W2164683872 @default.
• W2114443206 cites W2167714537 @default.
• W2114443206 cites W2259938310 @default.
• W2114443206 cites W4210767115 @default.
• W2114443206 doi "https://doi.org/10.1101/gr.190546.115" @default.
• W2114443206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4579340" @default.
• W2114443206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26228054" @default.
• W2114443206 hasPublicationYear "2015" @default.
• W2114443206 type Work @default.
• W2114443206 sameAs 2114443206 @default.
• W2114443206 citedByCount "49" @default.
• W2114443206 countsByYear W21144432062016 @default.
• W2114443206 countsByYear W21144432062017 @default.
• W2114443206 countsByYear W21144432062018 @default.
• W2114443206 countsByYear W21144432062019 @default.
• W2114443206 countsByYear W21144432062020 @default.
• W2114443206 countsByYear W21144432062021 @default.
• W2114443206 countsByYear W21144432062022 @default.
• W2114443206 countsByYear W21144432062023 @default.
• W2114443206 crossrefType "journal-article" @default.
• W2114443206 hasAuthorship W2114443206A5008886339 @default.
• W2114443206 hasAuthorship W2114443206A5026910430 @default.
• W2114443206 hasAuthorship W2114443206A5032097008 @default.
• W2114443206 hasAuthorship W2114443206A5051284054 @default.
• W2114443206 hasAuthorship W2114443206A5065938896 @default.
• W2114443206 hasAuthorship W2114443206A5066046411 @default.

• next