Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114450478> ?p ?o ?g. }
- W2114450478 endingPage "1781" @default.
- W2114450478 startingPage "1773" @default.
- W2114450478 abstract "L-Triiodothyronine (T3) stimulates DNA synthesis and replication of cultured GC cells, a T3-responsive growth hormone (GH)-secreting cell line. To determine whether T3 stimulates secretion of an autocrine growth factor, we compared the growth-promoting activity of medium conditioned by T3-stimulated and T3-depleted cells to that of unconditioned medium. Addition of polyclonal rabbit anti-T3 serum to T3-containing media decreased cellular T3 content by 50-70%. In unconditioned medium, anti-T3 serum decreased T3-induced cell growth and GH production by 40-70%. In conditioned medium, anti-T3 serum also effected a 45-70% decrease in induction of GH secretion but did not attenuate the growth-promoting activity. Growth-promoting activity was not detected in medium conditioned by T3-depleted cells. Thus, conditioned medium from T3-containing GC cell cultures contains growth-promoting activity that is independent of T3. Further, the induction of GC cel growth by T3 may occur, at least in part, by induction of an autocrine growth factor." @default.
- W2114450478 created "2016-06-24" @default.
- W2114450478 creator A5002120718 @default.
- W2114450478 creator A5003056295 @default.
- W2114450478 creator A5058865612 @default.
- W2114450478 creator A5091265699 @default.
- W2114450478 date "1987-06-01" @default.
- W2114450478 modified "2023-10-16" @default.
- W2114450478 title "L-triiodothyronine stimulates growth by means of an autocrine factor in a cultured growth-hormone-producing cell line." @default.
- W2114450478 cites W123333279 @default.
- W2114450478 cites W1512062815 @default.
- W2114450478 cites W1514956241 @default.
- W2114450478 cites W1572253237 @default.
- W2114450478 cites W1606138580 @default.
- W2114450478 cites W1775749144 @default.
- W2114450478 cites W1894641937 @default.
- W2114450478 cites W1970479527 @default.
- W2114450478 cites W1972209075 @default.
- W2114450478 cites W1980793481 @default.
- W2114450478 cites W1989493889 @default.
- W2114450478 cites W1992032967 @default.
- W2114450478 cites W1992623778 @default.
- W2114450478 cites W1994027777 @default.
- W2114450478 cites W1998507980 @default.
- W2114450478 cites W1999992445 @default.
- W2114450478 cites W2000319573 @default.
- W2114450478 cites W2001269746 @default.
- W2114450478 cites W2020348542 @default.
- W2114450478 cites W2032221161 @default.
- W2114450478 cites W2034205456 @default.
- W2114450478 cites W2034395629 @default.
- W2114450478 cites W2037200069 @default.
- W2114450478 cites W2046184324 @default.
- W2114450478 cites W2051110514 @default.
- W2114450478 cites W2053202457 @default.
- W2114450478 cites W2058542706 @default.
- W2114450478 cites W2059893173 @default.
- W2114450478 cites W2064177492 @default.
- W2114450478 cites W2065662041 @default.
- W2114450478 cites W2070546419 @default.
- W2114450478 cites W2072167381 @default.
- W2114450478 cites W2073323729 @default.
- W2114450478 cites W2073473087 @default.
- W2114450478 cites W2075729269 @default.
- W2114450478 cites W2081662410 @default.
- W2114450478 cites W2083891157 @default.
- W2114450478 cites W2084986896 @default.
- W2114450478 cites W2085338042 @default.
- W2114450478 cites W2086451995 @default.
- W2114450478 cites W2089428561 @default.
- W2114450478 cites W2093825674 @default.
- W2114450478 cites W2094504380 @default.
- W2114450478 cites W2095345459 @default.
- W2114450478 cites W2107636336 @default.
- W2114450478 cites W2108085784 @default.
- W2114450478 cites W2117909826 @default.
- W2114450478 cites W2132374234 @default.
- W2114450478 cites W2140320171 @default.
- W2114450478 cites W2151261265 @default.
- W2114450478 cites W2171860651 @default.
- W2114450478 cites W2473674018 @default.
- W2114450478 doi "https://doi.org/10.1172/jci113018" @default.
- W2114450478 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/424520" @default.
- W2114450478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3584469" @default.
- W2114450478 hasPublicationYear "1987" @default.
- W2114450478 type Work @default.
- W2114450478 sameAs 2114450478 @default.
- W2114450478 citedByCount "21" @default.
- W2114450478 crossrefType "journal-article" @default.
- W2114450478 hasAuthorship W2114450478A5002120718 @default.
- W2114450478 hasAuthorship W2114450478A5003056295 @default.
- W2114450478 hasAuthorship W2114450478A5058865612 @default.
- W2114450478 hasAuthorship W2114450478A5091265699 @default.
- W2114450478 hasBestOaLocation W21144504781 @default.
- W2114450478 hasConcept C126322002 @default.
- W2114450478 hasConcept C128240485 @default.
- W2114450478 hasConcept C134018914 @default.
- W2114450478 hasConcept C170493617 @default.
- W2114450478 hasConcept C185592680 @default.
- W2114450478 hasConcept C202751555 @default.
- W2114450478 hasConcept C2775960820 @default.
- W2114450478 hasConcept C2778288131 @default.
- W2114450478 hasConcept C49039625 @default.
- W2114450478 hasConcept C54355233 @default.
- W2114450478 hasConcept C55493867 @default.
- W2114450478 hasConcept C62112901 @default.
- W2114450478 hasConcept C64241487 @default.
- W2114450478 hasConcept C71315377 @default.
- W2114450478 hasConcept C71924100 @default.
- W2114450478 hasConcept C81885089 @default.
- W2114450478 hasConcept C86803240 @default.
- W2114450478 hasConcept C98648569 @default.
- W2114450478 hasConceptScore W2114450478C126322002 @default.
- W2114450478 hasConceptScore W2114450478C128240485 @default.
- W2114450478 hasConceptScore W2114450478C134018914 @default.
- W2114450478 hasConceptScore W2114450478C170493617 @default.
- W2114450478 hasConceptScore W2114450478C185592680 @default.
- W2114450478 hasConceptScore W2114450478C202751555 @default.