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- W2114472439 endingPage "H2871" @default.
- W2114472439 startingPage "H2865" @default.
- W2114472439 abstract "Low-density lipoproteins (LDL) are known to cause endothelial injury and to promote the development of atherosclerotic lesions. This study demonstrates a significant concentration-dependent stimulatory effect of LDL on hepatocyte growth factor (HGF) synthesis (maximum release: 423 +/- 16% of control) and HGF receptor mRNA expression in cultured human coronary artery endothelial cells (HCAEC). HGF is a potent mitogen for endothelial cells but does not affect smooth muscle cell proliferation. In contrast, endothelin-1 (ET-1) acts as a mitogen on vascular smooth muscle cells and seems to be upregulated in coronary atherosclerosis. In this study, the basal ET-1 synthesis in HCAEC was concentration-dependently reduced by HGF (minimum: 54 +/- 3% of control). This inhibitory effect seems to be mediated via the tyrosine kinase activity of the HGF receptor c-met, since it was antagonized by the tyrosine kinase inhibitor lavendustin A. In addition, HGF also significantly reduced the LDL-stimulated ET-1 release. The LDL-induced upregulation of HGF synthesis in HCAEC and the inhibitory effect of HGF on ET-1 synthesis suggest a protective role of HGF in coronary atherosclerosis." @default.
- W2114472439 created "2016-06-24" @default.
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- W2114472439 date "2000-12-01" @default.
- W2114472439 modified "2023-10-01" @default.
- W2114472439 title "Hepatocyte growth factor is upregulated by low-density lipoproteins and inhibits endothelin-1 release" @default.
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- W2114472439 doi "https://doi.org/10.1152/ajpheart.2000.279.6.h2865" @default.
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