FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114476260> ?p ?o ?g. }

• W2114476260 endingPage "413" @default.
• W2114476260 startingPage "398" @default.
• W2114476260 abstract "Rosmarinic acid is a polyphenolic compound and main constituent of Rosmarinus officinalis and has been shown to possess antioxidant and anti-inflammatory properties. We aimed to evaluate the anti-inflammatory properties of rosmarinic acid and of an extract of R. officinalis in local inflammation (carrageenin-induced paw oedema model in the rat), and further evaluate the protective effect of rosmarinic acid in rat models of systemic inflammation: liver ischaemia-reperfusion (I/R) and thermal injury models. In the local inflammation model, rosmarinic acid was administered at 10, 25 and 50 mg/kg (p.o.), and the extract was administered at 10 and 25 mg/kg (equivalent doses to rosmarinic acid groups) to male Wistar rats. Administration of rosmarinic acid and extract at the dose of 25 mg/kg reduced paw oedema at 6 hr by over 60%, exhibiting a dose-response effect, suggesting that rosmarinic was the main contributor to the anti-inflammatory effect. In the liver I/R model, rosmarinic acid was administered at 25 mg/kg (i.v.) 30 min. prior to the induction of ischaemia and led to the significant reduction in the serum concentration of transaminases (AST and ALT) and LDH. In the thermal injury model, rosmarinic acid was administered at 25 mg/kg (i.v.) 5 min. prior to the induction of injury and significantly reduced multi-organ dysfunction markers (liver, kidney, lung) by modulating NF-κB and metalloproteinase-9. For the first time, the anti-inflammatory potential of rosmarinic acid has been identified, as it causes a substantial reduction in inflammation, and we speculate that it might be useful in the pharmacological modulation of injuries associated to inflammation." @default.
• W2114476260 created "2016-06-24" @default.
• W2114476260 creator A5009571169 @default.
• W2114476260 creator A5042632378 @default.
• W2114476260 creator A5043846882 @default.
• W2114476260 creator A5049357095 @default.
• W2114476260 creator A5053708333 @default.
• W2114476260 creator A5054797240 @default.
• W2114476260 creator A5059925110 @default.
• W2114476260 creator A5069399864 @default.
• W2114476260 creator A5079226498 @default.
• W2114476260 creator A5081212806 @default.
• W2114476260 creator A5083171867 @default.
• W2114476260 creator A5084618730 @default.
• W2114476260 creator A5087016269 @default.
• W2114476260 creator A5088219344 @default.
• W2114476260 date "2014-11-06" @default.
• W2114476260 modified "2023-10-18" @default.
• W2114476260 title "Anti‐inflammatory Effect of Rosmarinic Acid and an Extract of <i>Rosmarinus officinalis</i> in Rat Models of Local and Systemic Inflammation" @default.
• W2114476260 cites W124335555 @default.
• W2114476260 cites W1534551308 @default.
• W2114476260 cites W1578101029 @default.
• W2114476260 cites W1822745879 @default.
• W2114476260 cites W1964493140 @default.
• W2114476260 cites W1965414352 @default.
• W2114476260 cites W1969747303 @default.
• W2114476260 cites W1970008312 @default.
• W2114476260 cites W1971692139 @default.
• W2114476260 cites W1973149534 @default.
• W2114476260 cites W1981703791 @default.
• W2114476260 cites W1983109902 @default.
• W2114476260 cites W1984883290 @default.
• W2114476260 cites W1985091566 @default.
• W2114476260 cites W1986463549 @default.
• W2114476260 cites W1986830986 @default.
• W2114476260 cites W1987825791 @default.
• W2114476260 cites W1988768595 @default.
• W2114476260 cites W1990819855 @default.
• W2114476260 cites W1992956731 @default.
• W2114476260 cites W1994768568 @default.
• W2114476260 cites W1996462445 @default.
• W2114476260 cites W1997755563 @default.
• W2114476260 cites W1998672948 @default.
• W2114476260 cites W2003027976 @default.
• W2114476260 cites W2005829070 @default.
• W2114476260 cites W2009649810 @default.
• W2114476260 cites W2013956503 @default.
• W2114476260 cites W2016730049 @default.
• W2114476260 cites W2019000940 @default.
• W2114476260 cites W2019872811 @default.
• W2114476260 cites W2027456987 @default.
• W2114476260 cites W2028132637 @default.
• W2114476260 cites W2029184736 @default.
• W2114476260 cites W2032849462 @default.
• W2114476260 cites W2032877170 @default.
• W2114476260 cites W2040981816 @default.
• W2114476260 cites W2053795936 @default.
• W2114476260 cites W2054358163 @default.
• W2114476260 cites W2061265621 @default.
• W2114476260 cites W2061596818 @default.
• W2114476260 cites W2063873306 @default.
• W2114476260 cites W2065235542 @default.
• W2114476260 cites W2071447200 @default.
• W2114476260 cites W2074188696 @default.
• W2114476260 cites W2074688366 @default.
• W2114476260 cites W2074966179 @default.
• W2114476260 cites W2075901022 @default.
• W2114476260 cites W2082230217 @default.
• W2114476260 cites W2084974626 @default.
• W2114476260 cites W2093680901 @default.
• W2114476260 cites W2094156327 @default.
• W2114476260 cites W2097600578 @default.
• W2114476260 cites W2107653141 @default.
• W2114476260 cites W2108329413 @default.
• W2114476260 cites W2114004260 @default.
• W2114476260 cites W2117724120 @default.
• W2114476260 cites W2120166207 @default.
• W2114476260 cites W2132446717 @default.
• W2114476260 cites W2136197942 @default.
• W2114476260 cites W2137847782 @default.
• W2114476260 cites W2140579802 @default.
• W2114476260 cites W2146004142 @default.
• W2114476260 cites W2157680121 @default.
• W2114476260 cites W2164574814 @default.
• W2114476260 cites W2168540880 @default.
• W2114476260 cites W2169079319 @default.
• W2114476260 cites W2182355171 @default.
• W2114476260 cites W2328140470 @default.
• W2114476260 cites W2330570895 @default.
• W2114476260 cites W3036294205 @default.
• W2114476260 cites W4251984459 @default.
• W2114476260 cites W85625969 @default.
• W2114476260 doi "https://doi.org/10.1111/bcpt.12335" @default.
• W2114476260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25287116" @default.
• W2114476260 hasPublicationYear "2014" @default.
• W2114476260 type Work @default.
• W2114476260 sameAs 2114476260 @default.
• W2114476260 citedByCount "181" @default.

• next