FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114481570> ?p ?o ?g. }

• W2114481570 endingPage "1965" @default.
• W2114481570 startingPage "1959" @default.
• W2114481570 abstract "Summary. Background: Brain death is associated with a systemic inflammatory response resulting in diminished organ function in individuals transplanted with organs from brain dead donors. As inflammation is accompanied by activation of coagulation, we hypothesized that activation of hemostasis occurs in brain dead organ donors. Objectives: To assess the hemostatic status in brain dead organ donors. Patients and methods: In this study, we systematically assessed the hemostatic system in samples taken from 30 brain dead donors. As controls, blood samples from 30 living kidney donors were included. Results and conclusions: Compared with the living donors, brain dead donors showed significant platelet activation (assessed by glycocalicin plasma levels), and a profound dysbalance in the von Willebrand factor/ADAMTS13 axis, which is key in platelet attachment to damaged vasculature. Furthermore, compared with the living donors, brain dead donors showed a significantly increased activation of secondary hemostasis with formation of fibrin (assessed by plasma levels of prothrombin fragment 1 + 2, fibrinopeptide A and D-dimer). Finally, brain dead donors showed profound hypofibrinolysis as assessed by a global clot lysis assay, which was attributed to substantially elevated plasma levels of plasminogen activator inhibitor type 1. Collectively, our results show activation of hemostasis and dysregulated fibrinolysis in brain dead organ donors. This prothrombotic state may contribute to formation of microthrombi in transplantable organs, which potentially contributes to deterioration of organ function." @default.
• W2114481570 created "2016-06-24" @default.
• W2114481570 creator A5000575733 @default.
• W2114481570 creator A5037152123 @default.
• W2114481570 creator A5048946142 @default.
• W2114481570 creator A5074302578 @default.
• W2114481570 date "2011-10-01" @default.
• W2114481570 modified "2023-09-30" @default.
• W2114481570 title "Activation of hemostasis in brain dead organ donors: an observational study" @default.
• W2114481570 cites W1854917621 @default.
• W2114481570 cites W1983335198 @default.
• W2114481570 cites W1984727897 @default.
• W2114481570 cites W1990038658 @default.
• W2114481570 cites W1990823740 @default.
• W2114481570 cites W1996718823 @default.
• W2114481570 cites W2003155618 @default.
• W2114481570 cites W2011644510 @default.
• W2114481570 cites W2016116321 @default.
• W2114481570 cites W2024628754 @default.
• W2114481570 cites W2026813398 @default.
• W2114481570 cites W2036091266 @default.
• W2114481570 cites W2036516754 @default.
• W2114481570 cites W2037460026 @default.
• W2114481570 cites W2045232268 @default.
• W2114481570 cites W2051015369 @default.
• W2114481570 cites W2060353243 @default.
• W2114481570 cites W2060836090 @default.
• W2114481570 cites W2086534463 @default.
• W2114481570 cites W2095384433 @default.
• W2114481570 cites W2099686970 @default.
• W2114481570 cites W2102488969 @default.
• W2114481570 cites W2104631810 @default.
• W2114481570 cites W2108519539 @default.
• W2114481570 cites W2123566103 @default.
• W2114481570 cites W2126656701 @default.
• W2114481570 cites W2136594380 @default.
• W2114481570 cites W2142293453 @default.
• W2114481570 cites W2147709343 @default.
• W2114481570 cites W2157147056 @default.
• W2114481570 cites W2168898621 @default.
• W2114481570 cites W2171968942 @default.
• W2114481570 cites W2322121630 @default.
• W2114481570 cites W2408854760 @default.
• W2114481570 cites W4298126626 @default.
• W2114481570 doi "https://doi.org/10.1111/j.1538-7836.2011.04442.x" @default.
• W2114481570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21762465" @default.
• W2114481570 hasPublicationYear "2011" @default.
• W2114481570 type Work @default.
• W2114481570 sameAs 2114481570 @default.
• W2114481570 citedByCount "23" @default.
• W2114481570 countsByYear W21144815702012 @default.
• W2114481570 countsByYear W21144815702013 @default.
• W2114481570 countsByYear W21144815702014 @default.
• W2114481570 countsByYear W21144815702015 @default.
• W2114481570 countsByYear W21144815702016 @default.
• W2114481570 countsByYear W21144815702017 @default.
• W2114481570 countsByYear W21144815702018 @default.
• W2114481570 countsByYear W21144815702019 @default.
• W2114481570 countsByYear W21144815702020 @default.
• W2114481570 countsByYear W21144815702021 @default.
• W2114481570 countsByYear W21144815702022 @default.
• W2114481570 countsByYear W21144815702023 @default.
• W2114481570 crossrefType "journal-article" @default.
• W2114481570 hasAuthorship W2114481570A5000575733 @default.
• W2114481570 hasAuthorship W2114481570A5037152123 @default.
• W2114481570 hasAuthorship W2114481570A5048946142 @default.
• W2114481570 hasAuthorship W2114481570A5074302578 @default.
• W2114481570 hasConcept C126322002 @default.
• W2114481570 hasConcept C142724271 @default.
• W2114481570 hasConcept C203014093 @default.
• W2114481570 hasConcept C2776246508 @default.
• W2114481570 hasConcept C2776825266 @default.
• W2114481570 hasConcept C2776914184 @default.
• W2114481570 hasConcept C2778382381 @default.
• W2114481570 hasConcept C2778589496 @default.
• W2114481570 hasConcept C2779394231 @default.
• W2114481570 hasConcept C2779679481 @default.
• W2114481570 hasConcept C2911091166 @default.
• W2114481570 hasConcept C3018697912 @default.
• W2114481570 hasConcept C3019123509 @default.
• W2114481570 hasConcept C54173615 @default.
• W2114481570 hasConcept C71924100 @default.
• W2114481570 hasConcept C89560881 @default.
• W2114481570 hasConceptScore W2114481570C126322002 @default.
• W2114481570 hasConceptScore W2114481570C142724271 @default.
• W2114481570 hasConceptScore W2114481570C203014093 @default.
• W2114481570 hasConceptScore W2114481570C2776246508 @default.
• W2114481570 hasConceptScore W2114481570C2776825266 @default.
• W2114481570 hasConceptScore W2114481570C2776914184 @default.
• W2114481570 hasConceptScore W2114481570C2778382381 @default.
• W2114481570 hasConceptScore W2114481570C2778589496 @default.
• W2114481570 hasConceptScore W2114481570C2779394231 @default.
• W2114481570 hasConceptScore W2114481570C2779679481 @default.
• W2114481570 hasConceptScore W2114481570C2911091166 @default.
• W2114481570 hasConceptScore W2114481570C3018697912 @default.
• W2114481570 hasConceptScore W2114481570C3019123509 @default.
• W2114481570 hasConceptScore W2114481570C54173615 @default.
• W2114481570 hasConceptScore W2114481570C71924100 @default.

• next