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• W2114490992 abstract "Abstract Determination and interpretation of fungal gene expression profiles based on digital reconstruction of expressed sequenced tags (ESTs) are reported. A total of 51,524 DNA sequence files processed with PipeOnline resulted in 9775 single and 5660 contig unique ESTs, 31.2% of a typical fungal transcriptome. Half of the unique ESTs shared homology with genes in public databases, 35.8% of which are functionally defined and 64.2% are unclear or unknown. In Aspergillus nidulans 86% of transcripts associate with intermediate metabolism functions, mainly related to carbohydrate, amino acid, protein, and peptide biosynthesis. During asexual development, A. nidulans unexpectedly accumulates stress response and inducer-dependent transcripts in the absence of an inducer. Stress response genes in A. nidulans ESTs total 1039 transcripts, contrasting with 117 in Neurospora crassa, a 14.3-fold difference. A total of 5.6% of A. nidulans ESTs implicate inducer-dependent cell wall degradation or amino acid acquisition, 3.5-fold higher than in N. crassa. Accumulation of stress response and inducer-dependent transcripts suggests general derepression of cis-regulation during terminal asexual development." @default.
• W2114490992 created "2016-06-24" @default.
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• W2114490992 date "2001-03-01" @default.
• W2114490992 modified "2023-10-16" @default.
• W2114490992 title "Accumulation of Stress and Inducer-Dependent Plant-Cell-Wall-Degrading Enzymes During Asexual Development in <i>Aspergillus nidulans</i>" @default.
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• W2114490992 doi "https://doi.org/10.1093/genetics/157.3.957" @default.
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