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- W2114499229 abstract "ABSTRACT Legionella pneumophila is a ubiquitous inhabitant of environmental water reservoirs. The bacteria infect a wide variety of protozoa and, after accidental inhalation, human alveolar macrophages, which can lead to severe pneumonia. The capability to thrive in phagocytic hosts is dependent on the Dot/Icm type IV secretion system (T4SS), which translocates multiple effector proteins into the host cell. In this study, we determined the draft genome sequence of L. pneumophila strain 130b (Wadsworth). We found that the 130b genome encodes a unique set of T4SSs, namely, the Dot/Icm T4SS, a Trb-1-like T4SS, and two Lvh T4SS gene clusters. Sequence analysis substantiated that a core set of 107 Dot/Icm T4SS effectors was conserved among the sequenced L. pneumophila strains Philadelphia-1, Lens, Paris, Corby, Alcoy, and 130b. We also identified new effector candidates and validated the translocation of 10 novel Dot/Icm T4SS effectors that are not present in L. pneumophila strain Philadelphia-1. We examined the prevalence of the new effector genes among 87 environmental and clinical L. pneumophila isolates. Five of the new effectors were identified in 34 to 62% of the isolates, while less than 15% of the strains tested positive for the other five genes. Collectively, our data show that the core set of conserved Dot/Icm T4SS effector proteins is supplemented by a variable repertoire of accessory effectors that may partly account for differences in the virulences and prevalences of particular L. pneumophila strains." @default.
- W2114499229 created "2016-06-24" @default.
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- W2114499229 date "2010-11-15" @default.
- W2114499229 modified "2023-10-16" @default.
- W2114499229 title "<i>Legionella pneumophila</i> Strain 130b Possesses a Unique Combination of Type IV Secretion Systems and Novel Dot/Icm Secretion System Effector Proteins" @default.
- W2114499229 cites W1550142680 @default.
- W2114499229 cites W1583410561 @default.
- W2114499229 cites W1844221752 @default.
- W2114499229 cites W1888347665 @default.
- W2114499229 cites W1936395475 @default.
- W2114499229 cites W1971857640 @default.
- W2114499229 cites W1971912164 @default.
- W2114499229 cites W1972093499 @default.
- W2114499229 cites W1973150982 @default.
- W2114499229 cites W1986997900 @default.
- W2114499229 cites W1988272131 @default.
- W2114499229 cites W1989102699 @default.
- W2114499229 cites W1994475681 @default.
- W2114499229 cites W1997600163 @default.
- W2114499229 cites W1999558106 @default.
- W2114499229 cites W2000193859 @default.
- W2114499229 cites W2002756887 @default.
- W2114499229 cites W2004101686 @default.
- W2114499229 cites W2008116827 @default.
- W2114499229 cites W2012053032 @default.
- W2114499229 cites W2016510254 @default.
- W2114499229 cites W2018063776 @default.
- W2114499229 cites W2021878136 @default.
- W2114499229 cites W2024468809 @default.
- W2114499229 cites W2024746774 @default.
- W2114499229 cites W2027502669 @default.
- W2114499229 cites W2029526066 @default.
- W2114499229 cites W2032057402 @default.
- W2114499229 cites W2032773353 @default.
- W2114499229 cites W2033828066 @default.
- W2114499229 cites W2034836766 @default.
- W2114499229 cites W2035333716 @default.
- W2114499229 cites W2037566791 @default.
- W2114499229 cites W2038143978 @default.
- W2114499229 cites W2040234046 @default.
- W2114499229 cites W2042577566 @default.
- W2114499229 cites W2050204065 @default.
- W2114499229 cites W2051133017 @default.
- W2114499229 cites W2055043387 @default.
- W2114499229 cites W2056979628 @default.
- W2114499229 cites W2060702462 @default.
- W2114499229 cites W2063839610 @default.
- W2114499229 cites W2065183886 @default.
- W2114499229 cites W2066220084 @default.
- W2114499229 cites W2066974855 @default.
- W2114499229 cites W2070549262 @default.
- W2114499229 cites W2071534662 @default.
- W2114499229 cites W2074613556 @default.
- W2114499229 cites W2077164447 @default.
- W2114499229 cites W2079580539 @default.
- W2114499229 cites W2080380824 @default.
- W2114499229 cites W2080747272 @default.
- W2114499229 cites W2081535038 @default.
- W2114499229 cites W2082928585 @default.
- W2114499229 cites W2083695927 @default.
- W2114499229 cites W2086799637 @default.
- W2114499229 cites W2098446792 @default.
- W2114499229 cites W2103546861 @default.
- W2114499229 cites W2104416424 @default.
- W2114499229 cites W2105537192 @default.
- W2114499229 cites W2107921573 @default.
- W2114499229 cites W2113609800 @default.
- W2114499229 cites W2116448293 @default.
- W2114499229 cites W2121052478 @default.
- W2114499229 cites W2121703775 @default.
- W2114499229 cites W2121950916 @default.
- W2114499229 cites W2123076427 @default.
- W2114499229 cites W2127683898 @default.
- W2114499229 cites W2130211377 @default.
- W2114499229 cites W2133255279 @default.
- W2114499229 cites W2133300547 @default.
- W2114499229 cites W2135541591 @default.
- W2114499229 cites W2135771899 @default.
- W2114499229 cites W2136246773 @default.
- W2114499229 cites W2137015675 @default.
- W2114499229 cites W2139436782 @default.
- W2114499229 cites W2139735735 @default.
- W2114499229 cites W2141885858 @default.
- W2114499229 cites W2142823843 @default.