FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114542867> ?p ?o ?g. }

• W2114542867 abstract "Abstract Background Anchorage independent growth is an important hallmark of oncogenic transformation. Previous studies have shown that when adhesion dependent fibroblasts were prevented from adhering to a substrate they underwent anoikis. In the present study we have demonstrated how anoikis resistant cells gain the transformation related properties with sequential selection of genes. We have proposed this process as a model system for selection of transformed cells from normal cells. Results This report demonstrates that some fibroblasts can survive during late stages of anoikis, at which time they exhibit transformation-associated properties such as in vitro colony formation in soft agar and in vivo subcutaneous tumour formation in nude mice. Cytogenetic characterisation of these cells revealed that they contained a t (2; 2) derivative chromosome and they have a selective survival advantage in non adherent conditions. Gene expression profile indicated that these cells over expressed genes related to hypoxia, glycolysis and tumor suppression/metastasis which could be helpful in their retaining a transformed phenotype. Conclusion Our results reveal some new links between anoikis and cell transformation and they provide a reproducible model system which can potentially be useful to study multistage cancer and to identify new targets for drug development." @default.
• W2114542867 created "2016-06-24" @default.
• W2114542867 creator A5010276069 @default.
• W2114542867 creator A5015225586 @default.
• W2114542867 creator A5046041605 @default.
• W2114542867 creator A5059353056 @default.
• W2114542867 creator A5065972545 @default.
• W2114542867 creator A5088102395 @default.
• W2114542867 creator A5089767948 @default.
• W2114542867 date "2010-12-01" @default.
• W2114542867 modified "2023-10-18" @default.
• W2114542867 title "Differential gene expression and clonal selection during cellular transformation induced by adhesion deprivation" @default.
• W2114542867 cites W1497663772 @default.
• W2114542867 cites W1968235802 @default.
• W2114542867 cites W1976501240 @default.
• W2114542867 cites W1980078391 @default.
• W2114542867 cites W1992160817 @default.
• W2114542867 cites W1999356404 @default.
• W2114542867 cites W2000244888 @default.
• W2114542867 cites W2001743102 @default.
• W2114542867 cites W2006680509 @default.
• W2114542867 cites W2017479895 @default.
• W2114542867 cites W2021741218 @default.
• W2114542867 cites W2023554081 @default.
• W2114542867 cites W2024289194 @default.
• W2114542867 cites W2053277232 @default.
• W2114542867 cites W2062214822 @default.
• W2114542867 cites W2079528456 @default.
• W2114542867 cites W2082483448 @default.
• W2114542867 cites W2086333179 @default.
• W2114542867 cites W2094153106 @default.
• W2114542867 cites W2104711019 @default.
• W2114542867 cites W2131266013 @default.
• W2114542867 cites W2131726139 @default.
• W2114542867 cites W2140575551 @default.
• W2114542867 cites W2143157552 @default.
• W2114542867 cites W2145139438 @default.
• W2114542867 cites W2145999972 @default.
• W2114542867 cites W2152387535 @default.
• W2114542867 cites W2157000380 @default.
• W2114542867 cites W2163894688 @default.
• W2114542867 cites W2401218311 @default.
• W2114542867 cites W4213141530 @default.
• W2114542867 cites W4236621639 @default.
• W2114542867 doi "https://doi.org/10.1186/1471-2121-11-93" @default.
• W2114542867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3012028" @default.
• W2114542867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21122158" @default.
• W2114542867 hasPublicationYear "2010" @default.
• W2114542867 type Work @default.
• W2114542867 sameAs 2114542867 @default.
• W2114542867 citedByCount "8" @default.
• W2114542867 countsByYear W21145428672012 @default.
• W2114542867 countsByYear W21145428672014 @default.
• W2114542867 countsByYear W21145428672015 @default.
• W2114542867 countsByYear W21145428672019 @default.
• W2114542867 crossrefType "journal-article" @default.
• W2114542867 hasAuthorship W2114542867A5010276069 @default.
• W2114542867 hasAuthorship W2114542867A5015225586 @default.
• W2114542867 hasAuthorship W2114542867A5046041605 @default.
• W2114542867 hasAuthorship W2114542867A5059353056 @default.
• W2114542867 hasAuthorship W2114542867A5065972545 @default.
• W2114542867 hasAuthorship W2114542867A5088102395 @default.
• W2114542867 hasAuthorship W2114542867A5089767948 @default.
• W2114542867 hasBestOaLocation W21145428671 @default.
• W2114542867 hasConcept C104317684 @default.
• W2114542867 hasConcept C121608353 @default.
• W2114542867 hasConcept C127716648 @default.
• W2114542867 hasConcept C1491633281 @default.
• W2114542867 hasConcept C152000582 @default.
• W2114542867 hasConcept C204241405 @default.
• W2114542867 hasConcept C31033888 @default.
• W2114542867 hasConcept C502942594 @default.
• W2114542867 hasConcept C54355233 @default.
• W2114542867 hasConcept C85789140 @default.
• W2114542867 hasConcept C86803240 @default.
• W2114542867 hasConcept C95444343 @default.
• W2114542867 hasConcept C96232424 @default.
• W2114542867 hasConceptScore W2114542867C104317684 @default.
• W2114542867 hasConceptScore W2114542867C121608353 @default.
• W2114542867 hasConceptScore W2114542867C127716648 @default.
• W2114542867 hasConceptScore W2114542867C1491633281 @default.
• W2114542867 hasConceptScore W2114542867C152000582 @default.
• W2114542867 hasConceptScore W2114542867C204241405 @default.
• W2114542867 hasConceptScore W2114542867C31033888 @default.
• W2114542867 hasConceptScore W2114542867C502942594 @default.
• W2114542867 hasConceptScore W2114542867C54355233 @default.
• W2114542867 hasConceptScore W2114542867C85789140 @default.
• W2114542867 hasConceptScore W2114542867C86803240 @default.
• W2114542867 hasConceptScore W2114542867C95444343 @default.
• W2114542867 hasConceptScore W2114542867C96232424 @default.
• W2114542867 hasIssue "1" @default.
• W2114542867 hasLocation W21145428671 @default.
• W2114542867 hasLocation W21145428672 @default.
• W2114542867 hasLocation W21145428673 @default.
• W2114542867 hasLocation W21145428674 @default.
• W2114542867 hasLocation W21145428675 @default.
• W2114542867 hasOpenAccess W2114542867 @default.
• W2114542867 hasPrimaryLocation W21145428671 @default.
• W2114542867 hasRelatedWork W1494166566 @default.
• W2114542867 hasRelatedWork W1556724276 @default.

• next