FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114559206> ?p ?o ?g. }

• W2114559206 endingPage "e59004" @default.
• W2114559206 startingPage "e59004" @default.
• W2114559206 abstract "Computational design of protein function involves a search for amino acids with the lowest energy subject to a set of constraints specifying function. In many cases a set of natural protein backbone structures, or scaffolds, are searched to find regions where functional sites (an enzyme active site, ligand binding pocket, protein-protein interaction region, etc.) can be placed, and the identities of the surrounding amino acids are optimized to satisfy functional constraints. Input native protein structures almost invariably have regions that score very poorly with the design force field, and any design based on these unmodified structures may result in mutations away from the native sequence solely as a result of the energetic strain. Because the input structure is already a stable protein, it is desirable to keep the total number of mutations to a minimum and to avoid mutations resulting from poorly-scoring input structures. Here we describe a protocol using cycles of minimization with combined backbone/sidechain restraints that is Pareto-optimal with respect to RMSD to the native structure and energetic strain reduction. The protocol should be broadly useful in the preparation of scaffold libraries for functional site design." @default.
• W2114559206 created "2016-06-24" @default.
• W2114559206 creator A5053192926 @default.
• W2114559206 creator A5069618541 @default.
• W2114559206 creator A5070699089 @default.
• W2114559206 date "2013-04-02" @default.
• W2114559206 modified "2023-10-11" @default.
• W2114559206 title "A Pareto-Optimal Refinement Method for Protein Design Scaffolds" @default.
• W2114559206 cites W1909149576 @default.
• W2114559206 cites W1969644422 @default.
• W2114559206 cites W1987696643 @default.
• W2114559206 cites W1991106911 @default.
• W2114559206 cites W1999648327 @default.
• W2114559206 cites W2033969841 @default.
• W2114559206 cites W2049275721 @default.
• W2114559206 cites W2066381187 @default.
• W2114559206 cites W2082260955 @default.
• W2114559206 cites W2103591844 @default.
• W2114559206 cites W2111387452 @default.
• W2114559206 cites W2115339329 @default.
• W2114559206 cites W2121627241 @default.
• W2114559206 cites W2125254321 @default.
• W2114559206 doi "https://doi.org/10.1371/journal.pone.0059004" @default.
• W2114559206 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3614904" @default.
• W2114559206 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23565140" @default.
• W2114559206 hasPublicationYear "2013" @default.
• W2114559206 type Work @default.
• W2114559206 sameAs 2114559206 @default.
• W2114559206 citedByCount "206" @default.
• W2114559206 countsByYear W21145592062013 @default.
• W2114559206 countsByYear W21145592062014 @default.
• W2114559206 countsByYear W21145592062015 @default.
• W2114559206 countsByYear W21145592062016 @default.
• W2114559206 countsByYear W21145592062017 @default.
• W2114559206 countsByYear W21145592062018 @default.
• W2114559206 countsByYear W21145592062019 @default.
• W2114559206 countsByYear W21145592062020 @default.
• W2114559206 countsByYear W21145592062021 @default.
• W2114559206 countsByYear W21145592062022 @default.
• W2114559206 countsByYear W21145592062023 @default.
• W2114559206 crossrefType "journal-article" @default.
• W2114559206 hasAuthorship W2114559206A5053192926 @default.
• W2114559206 hasAuthorship W2114559206A5069618541 @default.
• W2114559206 hasAuthorship W2114559206A5070699089 @default.
• W2114559206 hasBestOaLocation W21145592061 @default.
• W2114559206 hasConcept C126255220 @default.
• W2114559206 hasConcept C137635306 @default.
• W2114559206 hasConcept C14036430 @default.
• W2114559206 hasConcept C147764199 @default.
• W2114559206 hasConcept C147816474 @default.
• W2114559206 hasConcept C152769699 @default.
• W2114559206 hasConcept C177264268 @default.
• W2114559206 hasConcept C18051474 @default.
• W2114559206 hasConcept C181199279 @default.
• W2114559206 hasConcept C186060115 @default.
• W2114559206 hasConcept C199360897 @default.
• W2114559206 hasConcept C2778112365 @default.
• W2114559206 hasConcept C33923547 @default.
• W2114559206 hasConcept C41008148 @default.
• W2114559206 hasConcept C47701112 @default.
• W2114559206 hasConcept C54355233 @default.
• W2114559206 hasConcept C55493867 @default.
• W2114559206 hasConcept C70721500 @default.
• W2114559206 hasConcept C86803240 @default.
• W2114559206 hasConceptScore W2114559206C126255220 @default.
• W2114559206 hasConceptScore W2114559206C137635306 @default.
• W2114559206 hasConceptScore W2114559206C14036430 @default.
• W2114559206 hasConceptScore W2114559206C147764199 @default.
• W2114559206 hasConceptScore W2114559206C147816474 @default.
• W2114559206 hasConceptScore W2114559206C152769699 @default.
• W2114559206 hasConceptScore W2114559206C177264268 @default.
• W2114559206 hasConceptScore W2114559206C18051474 @default.
• W2114559206 hasConceptScore W2114559206C181199279 @default.
• W2114559206 hasConceptScore W2114559206C186060115 @default.
• W2114559206 hasConceptScore W2114559206C199360897 @default.
• W2114559206 hasConceptScore W2114559206C2778112365 @default.
• W2114559206 hasConceptScore W2114559206C33923547 @default.
• W2114559206 hasConceptScore W2114559206C41008148 @default.
• W2114559206 hasConceptScore W2114559206C47701112 @default.
• W2114559206 hasConceptScore W2114559206C54355233 @default.
• W2114559206 hasConceptScore W2114559206C55493867 @default.
• W2114559206 hasConceptScore W2114559206C70721500 @default.
• W2114559206 hasConceptScore W2114559206C86803240 @default.
• W2114559206 hasIssue "4" @default.
• W2114559206 hasLocation W21145592061 @default.
• W2114559206 hasLocation W21145592062 @default.
• W2114559206 hasLocation W21145592063 @default.
• W2114559206 hasLocation W21145592064 @default.
• W2114559206 hasOpenAccess W2114559206 @default.
• W2114559206 hasPrimaryLocation W21145592061 @default.
• W2114559206 hasRelatedWork W1594583051 @default.
• W2114559206 hasRelatedWork W1973460506 @default.
• W2114559206 hasRelatedWork W2035942032 @default.
• W2114559206 hasRelatedWork W2040374420 @default.
• W2114559206 hasRelatedWork W2094597106 @default.
• W2114559206 hasRelatedWork W2114559206 @default.
• W2114559206 hasRelatedWork W2116266427 @default.
• W2114559206 hasRelatedWork W2167707974 @default.

• next