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- W2114573135 abstract "During the development of the Drosophila embryonic epidermis, the secreted Wingless protein initially spreads symmetrically from its source. At later stages, Wingless becomes asymmetrically distributed in a Hedgehog-dependent manner, to control the patterning of the embryonic epidermis. When Wingless is misexpressed in engrailed cells in hedgehog heterozygous mutant embryos, larvae show a dominant phenotype consisting of patches of naked cuticle in denticle belts. This dose-sensitive phenotype is a direct consequence of a change in Wg protein distribution. We used this phenotype to carry out a screen for identifying genes regulating Wingless distribution or transport in the embryonic epidermis. Using a third chromosome deficiency collection, we found several genomic regions that showed a dominant interaction. After using a secondary screen to test for mutants and smaller deficiencies, we identified three interacting genes: dally, notum, and brahma. We confirmed that dally, as well as its homolog dally-like, and notum affect Wingless distribution in the embryonic epidermis, directly or indirectly. Thus, our assay can be used effectively to screen for genes regulating Wingless distribution or transport." @default.
- W2114573135 created "2016-06-24" @default.
- W2114573135 creator A5043249237 @default.
- W2114573135 creator A5046631149 @default.
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- W2114573135 date "2005-06-01" @default.
- W2114573135 modified "2023-09-26" @default.
- W2114573135 title "A Screen for Genes Regulating the Wingless Gradient in Drosophila Embryos" @default.
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- W2114573135 doi "https://doi.org/10.1534/genetics.105.040667" @default.
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