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• W2114579415 abstract "To elucidate the mechanism underlying rubratoxin B toxicity, the effects of rubratoxin B on the secretion of CCR5 chemokines, CCL3, CCL4, and CCL5, in a human promyelocytic leukemia cell line, HL60, were investigated. In addition, to examine whether the molecular chaperone 90-kDa heat shock protein (Hsp90) contributes to rubratoxin B toxicity, the effects of Hsp90-specific inhibitors, radicicol and geldanamycin, were investigated. Exposure to rubratoxin B for 24h induced secretion of each CCR5 chemokine, although the effect on CCL5 secretion was modest, and it enhanced secretion of proinflammatory cytokines tumor necrosis factor-α, CXCL8, and CCL2. Concomitant treatment with radicicol abolished the rubratoxin-induced secretion of all cytokines investigated. Geldanamycin antagonized the rubratoxin B-induced effects on CCL3 and CCL5, but not CCL4; the effects of geldanamycin were less than that of radicicol. Taken together, the results suggest that rubratoxin B, with the contribution of Hsp90, induces secretion of CCR5 chemokines." @default.
• W2114579415 created "2016-06-24" @default.
• W2114579415 creator A5008501681 @default.
• W2114579415 date "2015-11-01" @default.
• W2114579415 modified "2023-10-18" @default.
• W2114579415 title "Rubratoxin-B-induced secretion of chemokine ligands of cysteine–cysteine motif chemokine receptor 5 (CCR5) and its dependence on heat shock protein 90 in HL60 cells" @default.
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• W2114579415 doi "https://doi.org/10.1016/j.etap.2015.10.012" @default.
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