Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114580275> ?p ?o ?g. }
- W2114580275 endingPage "4639" @default.
- W2114580275 startingPage "4629" @default.
- W2114580275 abstract "We identified a novel Rho gene rho3(+) and studied its interaction with diaphanous/formin for3(+) in the fission yeast Schizosaccharomyces pombe. Both rho3 null cells and for3 null cells showed defects in organization of not only actin cytoskeleton but also cytoplasmic microtubules (MTs). rho3 for3 double null cells had defects that were more severe than each single null cell: polarized growth was deficient in the double null cells. Function of For3 needed the highly conserved FH1 and FH2 domains, an N-terminal region containing a Rho-binding domain, and the C-terminal region. For3 bound to active forms of both Rho3 and Cdc42 but not to that of Rho1. For3 was localized as dots to the ends of interphase cells and to the mid-region in dividing cells. This localization was probably dependent on its interaction with Rho proteins. Overexpression of For3 produced huge swollen cells containing depolarized F-actin patches and thick cytoplasmic MT bundles. In addition, overexpression of a constitutively active Rho3Q71L induced a strong defect in cytokinesis. In conclusion, we propose that the Rho3-For3 signaling system functions in the polarized cell growth of fission yeast by controlling both actin cytoskeleton and MTs." @default.
- W2114580275 created "2016-06-24" @default.
- W2114580275 creator A5008916918 @default.
- W2114580275 creator A5011884584 @default.
- W2114580275 creator A5015852408 @default.
- W2114580275 creator A5043367754 @default.
- W2114580275 creator A5067767778 @default.
- W2114580275 creator A5074768993 @default.
- W2114580275 date "2002-12-01" @default.
- W2114580275 modified "2023-10-17" @default.
- W2114580275 title "The small GTPase Rho3 and the diaphanous/formin For3 function in polarized cell growth in fission yeast" @default.
- W2114580275 cites W105110733 @default.
- W2114580275 cites W1527650585 @default.
- W2114580275 cites W1557401044 @default.
- W2114580275 cites W1856070105 @default.
- W2114580275 cites W1954954760 @default.
- W2114580275 cites W1973844181 @default.
- W2114580275 cites W1984653721 @default.
- W2114580275 cites W1989553220 @default.
- W2114580275 cites W1989598133 @default.
- W2114580275 cites W1990850141 @default.
- W2114580275 cites W1996084508 @default.
- W2114580275 cites W1997419253 @default.
- W2114580275 cites W2005676334 @default.
- W2114580275 cites W2007151220 @default.
- W2114580275 cites W2014569358 @default.
- W2114580275 cites W2019125570 @default.
- W2114580275 cites W2019808660 @default.
- W2114580275 cites W2022943167 @default.
- W2114580275 cites W2024095351 @default.
- W2114580275 cites W2033133245 @default.
- W2114580275 cites W2034092404 @default.
- W2114580275 cites W2042464607 @default.
- W2114580275 cites W2042498035 @default.
- W2114580275 cites W2054388798 @default.
- W2114580275 cites W2063826622 @default.
- W2114580275 cites W2066696278 @default.
- W2114580275 cites W2068878178 @default.
- W2114580275 cites W2070119451 @default.
- W2114580275 cites W2074307550 @default.
- W2114580275 cites W2077792958 @default.
- W2114580275 cites W2078188542 @default.
- W2114580275 cites W2088822716 @default.
- W2114580275 cites W2092727362 @default.
- W2114580275 cites W2096791952 @default.
- W2114580275 cites W2098093019 @default.
- W2114580275 cites W2103678110 @default.
- W2114580275 cites W2106100249 @default.
- W2114580275 cites W2106723342 @default.
- W2114580275 cites W2117494028 @default.
- W2114580275 cites W2117923494 @default.
- W2114580275 cites W2119194326 @default.
- W2114580275 cites W2120425861 @default.
- W2114580275 cites W2125781144 @default.
- W2114580275 cites W2129890878 @default.
- W2114580275 cites W2131582100 @default.
- W2114580275 cites W2133815229 @default.
- W2114580275 cites W2137016137 @default.
- W2114580275 cites W2139582633 @default.
- W2114580275 cites W2149694811 @default.
- W2114580275 cites W2154425220 @default.
- W2114580275 cites W2165650127 @default.
- W2114580275 cites W2177347112 @default.
- W2114580275 cites W2194986544 @default.
- W2114580275 cites W2234646024 @default.
- W2114580275 cites W2281196102 @default.
- W2114580275 cites W2311110868 @default.
- W2114580275 cites W2415089483 @default.
- W2114580275 doi "https://doi.org/10.1242/jcs.00150" @default.
- W2114580275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12415007" @default.
- W2114580275 hasPublicationYear "2002" @default.
- W2114580275 type Work @default.
- W2114580275 sameAs 2114580275 @default.
- W2114580275 citedByCount "100" @default.
- W2114580275 countsByYear W21145802752012 @default.
- W2114580275 countsByYear W21145802752013 @default.
- W2114580275 countsByYear W21145802752014 @default.
- W2114580275 countsByYear W21145802752015 @default.
- W2114580275 countsByYear W21145802752016 @default.
- W2114580275 countsByYear W21145802752017 @default.
- W2114580275 countsByYear W21145802752018 @default.
- W2114580275 countsByYear W21145802752020 @default.
- W2114580275 countsByYear W21145802752021 @default.
- W2114580275 countsByYear W21145802752023 @default.
- W2114580275 crossrefType "journal-article" @default.
- W2114580275 hasAuthorship W2114580275A5008916918 @default.
- W2114580275 hasAuthorship W2114580275A5011884584 @default.
- W2114580275 hasAuthorship W2114580275A5015852408 @default.
- W2114580275 hasAuthorship W2114580275A5043367754 @default.
- W2114580275 hasAuthorship W2114580275A5067767778 @default.
- W2114580275 hasAuthorship W2114580275A5074768993 @default.
- W2114580275 hasBestOaLocation W21145802751 @default.
- W2114580275 hasConcept C104317684 @default.
- W2114580275 hasConcept C121853132 @default.
- W2114580275 hasConcept C125705527 @default.
- W2114580275 hasConcept C142669718 @default.
- W2114580275 hasConcept C1491633281 @default.
- W2114580275 hasConcept C190062978 @default.