Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114582143> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2114582143 endingPage "4413" @default.
- W2114582143 startingPage "4407" @default.
- W2114582143 abstract "p56lck is a new member of the src family of cellular tyrosine protein kinases. It is expressed constitutively at a low level in normal T cells and at an elevated level in the LSTRA and Thy19 Moloney murine leukemia virus-induced thymoma cell lines. It is possible that the expression of p56lck at an elevated level contributes to the transformation of these thymoma cells. The structure of the mRNAs encoding p56lck was examined by using an RNase protection assay. Both a chimeric lck mRNA containing the 5' untranslated region of Moloney virus mRNA and a normal lck mRNA were found in Thy19 and LSTRA cells. The chimeric lck transcript was 4- to 10-fold more abundant than the normal transcript. Transcription arising from a viral promoter is therefore responsible for the elevated levels of lck mRNA in these two cell lines. Surprisingly, uninfected murine T cells were also found to contain lck transcripts with differing 5' untranslated regions. One species of mRNA was colinear with the region of the chromosome just upstream of the initiation codon for p56lck. The other appeared to arise through splicing of an unidentified 5' untranslated exon to a sometimes cryptic splice acceptor just upstream of the region encoding p56lck. These data suggest that lck is expressed through the use of at least two different promoters. The promoters could be subject to different forms of regulation." @default.
- W2114582143 created "2016-06-24" @default.
- W2114582143 creator A5038249166 @default.
- W2114582143 creator A5053274271 @default.
- W2114582143 creator A5083286597 @default.
- W2114582143 date "1987-12-01" @default.
- W2114582143 modified "2023-10-01" @default.
- W2114582143 title "Two lck transcripts containing different 5' untranslated regions are present in T cells" @default.
- W2114582143 cites W1529013613 @default.
- W2114582143 cites W1983302719 @default.
- W2114582143 cites W2007643304 @default.
- W2114582143 cites W2008936546 @default.
- W2114582143 cites W2019300008 @default.
- W2114582143 cites W2028833639 @default.
- W2114582143 cites W2034280067 @default.
- W2114582143 cites W2046390100 @default.
- W2114582143 cites W2060333964 @default.
- W2114582143 cites W2072229642 @default.
- W2114582143 cites W2077326676 @default.
- W2114582143 cites W2078119356 @default.
- W2114582143 cites W2088215519 @default.
- W2114582143 cites W2100799887 @default.
- W2114582143 cites W2138270253 @default.
- W2114582143 cites W2336728022 @default.
- W2114582143 cites W2494426390 @default.
- W2114582143 cites W308192550 @default.
- W2114582143 doi "https://doi.org/10.1128/mcb.7.12.4407-4413.1987" @default.
- W2114582143 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/368124" @default.
- W2114582143 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3501824" @default.
- W2114582143 hasPublicationYear "1987" @default.
- W2114582143 type Work @default.
- W2114582143 sameAs 2114582143 @default.
- W2114582143 citedByCount "33" @default.
- W2114582143 countsByYear W21145821432013 @default.
- W2114582143 countsByYear W21145821432016 @default.
- W2114582143 countsByYear W21145821432023 @default.
- W2114582143 crossrefType "journal-article" @default.
- W2114582143 hasAuthorship W2114582143A5038249166 @default.
- W2114582143 hasAuthorship W2114582143A5053274271 @default.
- W2114582143 hasAuthorship W2114582143A5083286597 @default.
- W2114582143 hasConcept C101762097 @default.
- W2114582143 hasConcept C104317684 @default.
- W2114582143 hasConcept C105580179 @default.
- W2114582143 hasConcept C12464233 @default.
- W2114582143 hasConcept C150194340 @default.
- W2114582143 hasConcept C153911025 @default.
- W2114582143 hasConcept C159047783 @default.
- W2114582143 hasConcept C22667442 @default.
- W2114582143 hasConcept C2522874641 @default.
- W2114582143 hasConcept C2779562191 @default.
- W2114582143 hasConcept C36823959 @default.
- W2114582143 hasConcept C54355233 @default.
- W2114582143 hasConcept C54458228 @default.
- W2114582143 hasConcept C67705224 @default.
- W2114582143 hasConcept C86803240 @default.
- W2114582143 hasConcept C89604277 @default.
- W2114582143 hasConceptScore W2114582143C101762097 @default.
- W2114582143 hasConceptScore W2114582143C104317684 @default.
- W2114582143 hasConceptScore W2114582143C105580179 @default.
- W2114582143 hasConceptScore W2114582143C12464233 @default.
- W2114582143 hasConceptScore W2114582143C150194340 @default.
- W2114582143 hasConceptScore W2114582143C153911025 @default.
- W2114582143 hasConceptScore W2114582143C159047783 @default.
- W2114582143 hasConceptScore W2114582143C22667442 @default.
- W2114582143 hasConceptScore W2114582143C2522874641 @default.
- W2114582143 hasConceptScore W2114582143C2779562191 @default.
- W2114582143 hasConceptScore W2114582143C36823959 @default.
- W2114582143 hasConceptScore W2114582143C54355233 @default.
- W2114582143 hasConceptScore W2114582143C54458228 @default.
- W2114582143 hasConceptScore W2114582143C67705224 @default.
- W2114582143 hasConceptScore W2114582143C86803240 @default.
- W2114582143 hasConceptScore W2114582143C89604277 @default.
- W2114582143 hasIssue "12" @default.
- W2114582143 hasLocation W21145821431 @default.
- W2114582143 hasOpenAccess W2114582143 @default.
- W2114582143 hasPrimaryLocation W21145821431 @default.
- W2114582143 hasRelatedWork W1966512561 @default.
- W2114582143 hasRelatedWork W1984637510 @default.
- W2114582143 hasRelatedWork W2005735275 @default.
- W2114582143 hasRelatedWork W2018914487 @default.
- W2114582143 hasRelatedWork W2048723174 @default.
- W2114582143 hasRelatedWork W2060683174 @default.
- W2114582143 hasRelatedWork W2075154092 @default.
- W2114582143 hasRelatedWork W2092849069 @default.
- W2114582143 hasRelatedWork W2110910809 @default.
- W2114582143 hasRelatedWork W2162618419 @default.
- W2114582143 hasVolume "7" @default.
- W2114582143 isParatext "false" @default.
- W2114582143 isRetracted "false" @default.
- W2114582143 magId "2114582143" @default.
- W2114582143 workType "article" @default.