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- W2114586089 endingPage "1448" @default.
- W2114586089 startingPage "1437" @default.
- W2114586089 abstract "Here we challenge the view that reward-guided learning is solely controlled by the mesoaccumbens pathway arising from dopaminergic neurons in the ventral tegmental area and projecting to the nucleus accumbens. This widely accepted view assumes that reward is a monolithic concept, but recent work has suggested otherwise. It now appears that, in reward-guided learning, the functions of ventral and dorsal striata, and the cortico-basal ganglia circuitry associated with them, can be dissociated. Whereas the nucleus accumbens is necessary for the acquisition and expression of certain appetitive Pavlovian responses and contributes to the motivational control of instrumental performance, the dorsal striatum is necessary for the acquisition and expression of instrumental actions. Such findings suggest the existence of multiple independent yet interacting functional systems that are implemented in iterating and hierarchically organized cortico-basal ganglia networks engaged in appetitive behaviors ranging from Pavlovian approach responses to goal-directed instrumental actions controlled by action-outcome contingencies." @default.
- W2114586089 created "2016-06-24" @default.
- W2114586089 creator A5017732562 @default.
- W2114586089 creator A5027117815 @default.
- W2114586089 creator A5087840723 @default.
- W2114586089 date "2008-10-01" @default.
- W2114586089 modified "2023-09-25" @default.
- W2114586089 title "Reward-guided learning beyond dopamine in the nucleus accumbens: the integrative functions of cortico-basal ganglia networks" @default.
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