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• W2114594150 abstract "Cytomegalovirus (CMV) remains the single most important pathogen following solid organ transplantation. 1 Fishman J.A. Rubin R.H. Infection in organ-transplant recipients. N Engl J Med. 1998; 338: 1741-1751 Crossref PubMed Scopus (1338) Google Scholar This is perhaps no better illustrated than in clinical lung transplantation, where CMV remains a major cause of morbidity and mortality. In addition to its short-term effects of tissue injury and clinical illness, CMV may have important long-term sequelae in the lung allograft. CMV, via mechanisms of enhanced allorecognition, has been associated with, although not causally linked, to the development of acute and chronic rejection. 2 Duncan S.R. Paradis I.L. Yousem S.A. Similo S.L. Grgurich W.F. Williams P.A. Dauber J.H. Griffith B.P. Sequelae of cytomegalovirus pulmonary infections in lung allograft recipients. Am Rev Respir Dis. 1992; 146: 1419-1425 Crossref PubMed Scopus (144) Google Scholar Ganciclovir (GCV) treatment of established disease may not alter CMV-induced immunopathogenic mechanisms leading to the development of chronic allograft failure. CMV induces augmented immunosuppression that predisposes patients to infection with opportunistic organisms or the development of post-transplant lymphoproliferative disease. 3 Snydman D.R. Infection in solid organ transplantation. Transplant Infect Dis. 1999; 1: 21-28 Crossref PubMed Scopus (116) Google Scholar CMV has also been shown to increase the costs associated with solid organ transplants by 40% to 50%. 4 McCarthy J.M. Karim M.A. Krueger H. Keown P.A. The cost impact of cytomegalovirus disease in renal transplant recipients. Transplantation. 1993; 55: 1277-1282 Crossref PubMed Scopus (79) Google Scholar , 5 Falagas M.E. Arbo M. Ruthhazer R. Griffith J.L. Werner B.G. Rohrer R. Freeman R. Lewis W.D. Snydman D.R. Cytomegalovirus disease is associated with increased cost and hospital length of stay among orthotopic liver transplant recipients. Transplantation. 1997; 63: 1595-1601 Crossref PubMed Scopus (70) Google Scholar , 6 Kim W.R. Badley A.D. Weisner R.H. Porayko M.K. Seaberg E.C. Keating M.R. Evans R.W. Dickson E.R. Krom R.A.F. Paya C.V. The economic impact of cytomegalovirus infection after liver transplantation. Transplantation. 2000; 69: 357-361 Crossref PubMed Scopus (75) Google Scholar These observations have led to the use of various strategies for the prevention, early diagnosis and treatment for CMV infection. However, despite more than a decade of experience with lung transplantation and the availability of GCV, the management of CMV in these patients remains controversial." @default.
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• W2114594150 date "2002-08-01" @default.
• W2114594150 modified "2023-09-28" @default.
• W2114594150 title "Controversies in lung transplantation: management of cytomegalovirus infections" @default.
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• W2114594150 doi "https://doi.org/10.1016/s1053-2498(02)00435-7" @default.
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