FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114600277> ?p ?o ?g. }

• W2114600277 endingPage "1034" @default.
• W2114600277 startingPage "1019" @default.
• W2114600277 abstract "Metabotropic glutamate receptors (mGluRs) include receptors sensitive to L-2-amino-4-phosphonobutyrate (L-AP4) and 1S,3R-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD). To determine whether 1S,3R-ACPD is an agonist at retinal L-AP4 receptors, whole cell voltage clamp recordings were obtained from mudpuppy ON bipolar cells in a superfused retinal slice and L-AP4 and 1S,3R-ACPD were bath applied. Both compounds evoked similar outward currents which reversed near 0 mV and were accompanied by an increased input resistance. Responses to both agonists washed out in parallel suggesting they act through the same second messenger pathway(s). Inhibitors of cGMP-PDE activity suppressed responses to both L-AP4 and 1SR,3RS-ACPD, suggesting that both compounds activate cGMP-PDE. Responses to 1S,3R-ACPD were occluded by prior activation of L-AP4 receptors, but not blocked by the non-AP4, mGluR antagonists, L-aminophosphonopropionic acid (L-AP3) or 4-carboxy-3-hydroxyphenylglycine (4C3H-PG). These results indicate that 1S,3R-ACPD is an agonist at L-AP4 receptors. 1S,3S-ACPD and 4C3H-PG evoked outward currents similar to L-AP4 suggesting they may also be L-AP4 receptor agonists. Using the b-wave of the ERG as an assay for ON bipolar cell responses, concentration/response curves were obtained for ACPD enantiomers. The rank-order potency of ACPD enantiomers at L-AP4 receptors in ON bipolar cells is similar to their rank-order potency at non-AP4, mGluRs in brain which suggests that the receptors possess similar binding sites and may be members of a common receptor family." @default.
• W2114600277 created "2016-06-24" @default.
• W2114600277 creator A5019489957 @default.
• W2114600277 creator A5077784304 @default.
• W2114600277 date "1994-06-01" @default.
• W2114600277 modified "2023-10-11" @default.
• W2114600277 title "Actions of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid (1S,3R-ACPD) in retinal ON bipolar cells indicate that it is an agonist at L-AP4 receptors." @default.
• W2114600277 cites W1688027874 @default.
• W2114600277 cites W1764773484 @default.
• W2114600277 cites W1842711843 @default.
• W2114600277 cites W1927317897 @default.
• W2114600277 cites W1971186006 @default.
• W2114600277 cites W1972077152 @default.
• W2114600277 cites W1972183007 @default.
• W2114600277 cites W1980135035 @default.
• W2114600277 cites W2001744744 @default.
• W2114600277 cites W2004668023 @default.
• W2114600277 cites W2007933423 @default.
• W2114600277 cites W2020461481 @default.
• W2114600277 cites W2025396999 @default.
• W2114600277 cites W2027970976 @default.
• W2114600277 cites W2035115219 @default.
• W2114600277 cites W2043339467 @default.
• W2114600277 cites W2043529380 @default.
• W2114600277 cites W2048381454 @default.
• W2114600277 cites W2048755709 @default.
• W2114600277 cites W2055261660 @default.
• W2114600277 cites W2056440524 @default.
• W2114600277 cites W2060745612 @default.
• W2114600277 cites W2062957466 @default.
• W2114600277 cites W2066439059 @default.
• W2114600277 cites W2066439205 @default.
• W2114600277 cites W2067317040 @default.
• W2114600277 cites W2068526097 @default.
• W2114600277 cites W2070027885 @default.
• W2114600277 cites W2072060769 @default.
• W2114600277 cites W2078935283 @default.
• W2114600277 cites W2083029213 @default.
• W2114600277 cites W2085210285 @default.
• W2114600277 cites W2085988072 @default.
• W2114600277 cites W2086760534 @default.
• W2114600277 cites W2090006256 @default.
• W2114600277 cites W2093440950 @default.
• W2114600277 cites W2093734160 @default.
• W2114600277 cites W2094099092 @default.
• W2114600277 cites W2100040827 @default.
• W2114600277 cites W2129933607 @default.
• W2114600277 cites W2134271696 @default.
• W2114600277 cites W2149201522 @default.
• W2114600277 cites W2161584310 @default.
• W2114600277 cites W2164293375 @default.
• W2114600277 cites W2257880885 @default.
• W2114600277 cites W2341695286 @default.
• W2114600277 cites W2344386196 @default.
• W2114600277 doi "https://doi.org/10.1085/jgp.103.6.1019" @default.
• W2114600277 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2216887" @default.
• W2114600277 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7931135" @default.
• W2114600277 hasPublicationYear "1994" @default.
• W2114600277 type Work @default.
• W2114600277 sameAs 2114600277 @default.
• W2114600277 citedByCount "15" @default.
• W2114600277 countsByYear W21146002772020 @default.
• W2114600277 countsByYear W21146002772022 @default.
• W2114600277 crossrefType "journal-article" @default.
• W2114600277 hasAuthorship W2114600277A5019489957 @default.
• W2114600277 hasAuthorship W2114600277A5077784304 @default.
• W2114600277 hasBestOaLocation W21146002771 @default.
• W2114600277 hasConcept C12554922 @default.
• W2114600277 hasConcept C169760540 @default.
• W2114600277 hasConcept C170493617 @default.
• W2114600277 hasConcept C26702167 @default.
• W2114600277 hasConcept C2777603759 @default.
• W2114600277 hasConcept C2778938600 @default.
• W2114600277 hasConcept C49051014 @default.
• W2114600277 hasConcept C55493867 @default.
• W2114600277 hasConcept C61174792 @default.
• W2114600277 hasConcept C86803240 @default.
• W2114600277 hasConceptScore W2114600277C12554922 @default.
• W2114600277 hasConceptScore W2114600277C169760540 @default.
• W2114600277 hasConceptScore W2114600277C170493617 @default.
• W2114600277 hasConceptScore W2114600277C26702167 @default.
• W2114600277 hasConceptScore W2114600277C2777603759 @default.
• W2114600277 hasConceptScore W2114600277C2778938600 @default.
• W2114600277 hasConceptScore W2114600277C49051014 @default.
• W2114600277 hasConceptScore W2114600277C55493867 @default.
• W2114600277 hasConceptScore W2114600277C61174792 @default.
• W2114600277 hasConceptScore W2114600277C86803240 @default.
• W2114600277 hasIssue "6" @default.
• W2114600277 hasLocation W21146002771 @default.
• W2114600277 hasLocation W21146002772 @default.
• W2114600277 hasLocation W21146002773 @default.
• W2114600277 hasLocation W21146002774 @default.
• W2114600277 hasLocation W21146002775 @default.
• W2114600277 hasOpenAccess W2114600277 @default.
• W2114600277 hasPrimaryLocation W21146002771 @default.
• W2114600277 hasRelatedWork W1570554881 @default.
• W2114600277 hasRelatedWork W1973684832 @default.
• W2114600277 hasRelatedWork W2009311043 @default.

• next