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• W2114602553 abstract "drogenase (LDH), B symptoms, bone marrow involvement, and advanced stage. Progression-free survival (PFS; 0%) and overall survival (OS; 23.3%) rates were significantly lower in patients with the dual translocation than in those with other translocation (compared with PFS rates 36.1% to 69.8% and OS rates 65.2% to 83.7%; P =.001 for all comparisons). 6 A single-center analysis of 53 patients with DLBCL identified 17 cases of DHL by FISH or metaphase karyotyping. Median OS was significantly shorter for DHL compared with non-DHL (8.2 vs 56.8 months; P <.001). 7 Another study identified 54 (4%) of 1260 patients with lymphoma with dual translocation by FISH. This group was more likely to have bone marrow involvement, a high International Prognostic Index (IPI) score, and to have demonstrated a median OS of less than 1 year. 5 MD Anderson reported its experience with 129 cases of DHLs. The 2-year eventfree survival (EFS) was much lower than reported outcomes in patients with DLBCL and was reported as 25%, 67%, and 32% in patients who received R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone), R-EPOCH (rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin), and R-Hyper-CVAD/MA (rituximab-hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone/methotrexate-cytarabine), respectively. 8 As a result of the poor clinical outcomes in this subset of DLBCL, much research interest has been directed at DHL in the past few years. Many clinical controversies in diagnosis and treatment surround this subtype of lymphoma, and this article’s aim is to review and provide our input regarding these controversies. Controversy #1: Is the current definition of “double-hit” lymphoma adequate?" @default.
• W2114602553 created "2016-06-24" @default.
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• W2114602553 date "2015-04-20" @default.
• W2114602553 modified "2023-09-23" @default.
• W2114602553 title "Clinical Controversies of Double-Hit Lymphoma" @default.
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