FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114606300> ?p ?o ?g. }

• W2114606300 abstract "The identification of early, preferably presymptomatic, biomarkers and true etiologic factors for Alzheimer’s disease (AD) is the first step toward establishing effective primary and secondary prevention programs. Consequently, the search for a relatively inexpensive and harmless biomarker for AD continues. Despite intensive research worldwide, to date there is no definitive plasma or blood biomarker indicating high or low risk of conversion to AD. Magnetic resonance imaging and β -amyloid (Aβ) levels in three blood compartments (diluted in plasma, undiluted in plasma and cell-bound) were measured in 96 subjects (33 with mild cognitive impairment, 14 with AD and 49 healthy controls). Pearson correlations were completed between 113 regions of interest (ROIs) (45 subcortical and 68 cortical) and Aβ levels. Pearson correlation analyses adjusted for the covariates age, sex, apolipoprotein E (ApoE), education and creatinine levels showed neuroimaging ROIs were associated with Aβ levels. Two statistical methods were applied to study the major relationships identified: (1) Pearson correlation with phenotype added as a covariate and (2) a meta-analysis stratified by phenotype. Neuroimaging data and plasma Aβ measurements were taken from 630 Alzheimer’s Disease Neuroimaging Initiative (ADNI) subjects to be compared with our results. The left hippocampus was the brain region most correlated with Aβ(1 - 40) bound to blood cell pellets (partial correlation (pcor) = − 0.37, P = 0.0007) after adjustment for the covariates age, gender and education, ApoE and creatinine levels. The correlation remained almost the same (pcor = − 0.35, P = 0.002) if phenotype is also added as a covariate. The association between both measurements was independent of cognitive status. The left hemisphere entorhinal cortex also correlated with Aβ(1 - 40) cell-bound fraction. AB128 and ADNI plasma Aβ measurements were not related to any brain morphometric measurement. Association of cell-bound A β(1 - 40) in blood with left hippocampal volume was much stronger than previously observed in A β plasma fractions. If confirmed, this observation will require careful interpretation and must be taken into account for blood amyloid-based biomarker development." @default.
• W2114606300 created "2016-06-24" @default.
• W2114606300 creator A5004584329 @default.
• W2114606300 creator A5014788787 @default.
• W2114606300 creator A5016981559 @default.
• W2114606300 creator A5029554092 @default.
• W2114606300 creator A5035991320 @default.
• W2114606300 creator A5046904387 @default.
• W2114606300 creator A5047927157 @default.
• W2114606300 creator A5050897246 @default.
• W2114606300 creator A5057731725 @default.
• W2114606300 creator A5058223155 @default.
• W2114606300 creator A5058849422 @default.
• W2114606300 creator A5059526712 @default.
• W2114606300 creator A5071125745 @default.
• W2114606300 creator A5071676688 @default.
• W2114606300 creator A5090349588 @default.
• W2114606300 date "2014-10-01" @default.
• W2114606300 modified "2023-10-18" @default.
• W2114606300 title "Association between cell-bound blood amyloid-β(1 - 40) levels and hippocampus volume" @default.
• W2114606300 cites W1554629034 @default.
• W2114606300 cites W1970152641 @default.
• W2114606300 cites W1973728640 @default.
• W2114606300 cites W1976899564 @default.
• W2114606300 cites W1983355263 @default.
• W2114606300 cites W1985879372 @default.
• W2114606300 cites W2007044705 @default.
• W2114606300 cites W2017330669 @default.
• W2114606300 cites W2017779103 @default.
• W2114606300 cites W2028768126 @default.
• W2114606300 cites W2035079822 @default.
• W2114606300 cites W2041004450 @default.
• W2114606300 cites W2047547762 @default.
• W2114606300 cites W2054995979 @default.
• W2114606300 cites W2064156568 @default.
• W2114606300 cites W2065184319 @default.
• W2114606300 cites W2069117203 @default.
• W2114606300 cites W2098947303 @default.
• W2114606300 cites W2104048700 @default.
• W2114606300 cites W2106931873 @default.
• W2114606300 cites W2117047219 @default.
• W2114606300 cites W2127108221 @default.
• W2114606300 cites W2127324977 @default.
• W2114606300 cites W2138841544 @default.
• W2114606300 cites W2139886607 @default.
• W2114606300 cites W2151409655 @default.
• W2114606300 cites W2154705555 @default.
• W2114606300 cites W2156220037 @default.
• W2114606300 cites W2159122349 @default.
• W2114606300 cites W4249565903 @default.
• W2114606300 doi "https://doi.org/10.1186/s13195-014-0056-3" @default.
• W2114606300 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4255526" @default.
• W2114606300 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25484928" @default.
• W2114606300 hasPublicationYear "2014" @default.
• W2114606300 type Work @default.
• W2114606300 sameAs 2114606300 @default.
• W2114606300 citedByCount "9" @default.
• W2114606300 countsByYear W21146063002015 @default.
• W2114606300 countsByYear W21146063002016 @default.
• W2114606300 countsByYear W21146063002017 @default.
• W2114606300 countsByYear W21146063002019 @default.
• W2114606300 countsByYear W21146063002020 @default.
• W2114606300 countsByYear W21146063002023 @default.
• W2114606300 crossrefType "journal-article" @default.
• W2114606300 hasAuthorship W2114606300A5004584329 @default.
• W2114606300 hasAuthorship W2114606300A5014788787 @default.
• W2114606300 hasAuthorship W2114606300A5016981559 @default.
• W2114606300 hasAuthorship W2114606300A5029554092 @default.
• W2114606300 hasAuthorship W2114606300A5035991320 @default.
• W2114606300 hasAuthorship W2114606300A5046904387 @default.
• W2114606300 hasAuthorship W2114606300A5047927157 @default.
• W2114606300 hasAuthorship W2114606300A5050897246 @default.
• W2114606300 hasAuthorship W2114606300A5057731725 @default.
• W2114606300 hasAuthorship W2114606300A5058223155 @default.
• W2114606300 hasAuthorship W2114606300A5058849422 @default.
• W2114606300 hasAuthorship W2114606300A5059526712 @default.
• W2114606300 hasAuthorship W2114606300A5071125745 @default.
• W2114606300 hasAuthorship W2114606300A5071676688 @default.
• W2114606300 hasAuthorship W2114606300A5090349588 @default.
• W2114606300 hasBestOaLocation W21146063001 @default.
• W2114606300 hasConcept C105795698 @default.
• W2114606300 hasConcept C117220453 @default.
• W2114606300 hasConcept C118552586 @default.
• W2114606300 hasConcept C119043178 @default.
• W2114606300 hasConcept C126322002 @default.
• W2114606300 hasConcept C126838900 @default.
• W2114606300 hasConcept C142724271 @default.
• W2114606300 hasConcept C143409427 @default.
• W2114606300 hasConcept C143998085 @default.
• W2114606300 hasConcept C15744967 @default.
• W2114606300 hasConcept C2524010 @default.
• W2114606300 hasConcept C2778373026 @default.
• W2114606300 hasConcept C2779134260 @default.
• W2114606300 hasConcept C2780306776 @default.
• W2114606300 hasConcept C2781073650 @default.
• W2114606300 hasConcept C2781161787 @default.
• W2114606300 hasConcept C2781197716 @default.
• W2114606300 hasConcept C33923547 @default.
• W2114606300 hasConcept C502032728 @default.
• W2114606300 hasConcept C54355233 @default.

• next