FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114606427> ?p ?o ?g. }

• W2114606427 endingPage "609" @default.
• W2114606427 startingPage "601" @default.
• W2114606427 abstract "The increasingly recognized prevalence of first-step parC mutants in Streptococcus pneumoniae and the development of de novo resistance while on fluoroquinolone therapy are of concern. Previous work by our group demonstrated the ability of moxifloxacin, but not levofloxacin, to eradicate parC mutants. The objective of this experiment was to determine whether these fluoroquinolone antibiotics provided equivalent bacterial kill when similar AUC/MICs were examined.An in vitro pharmacodynamic model was used to simulate the epithelial lining fluid (ELF) concentrations following oral administration of levofloxacin 500 mg once daily and moxifloxacin 400 mg once daily in older adults. In addition, a range of AUC/MICs were also modelled, including levofloxacin 750 mg once daily. Five different S. pneumoniae containing first-step parC mutations and one isolate without mutations were tested for 48 h and time-kill curves were constructed. Samples at 0, 24 and 48 h were collected for phenotypic and genotypic profiling. HPLC was used to verify that target exposures were achieved.The isolate without a parC mutation displayed a 4 log reduction in cfu after treatment with levofloxacin 500 mg and did not select for resistance. In all five isolates containing first-step parC mutations, resistance emerged within 48 h with a > or =16-fold increase in MIC and the acquisition of a gyrA mutant. Increasing the exposure of levofloxacin to approximately 750 mg dose still led to > or =16-fold increase in MIC at 48 h in two of the four isolates containing parC mutations. On the other hand, moxifloxacin 400 mg sustained bacterial killing against the two isolates tested without the selection of resistant mutants. It appears that the critical AUC/MIC necessary to prevent the acquisition of resistance for levofloxacin is 200 and approximately 400 for moxifloxacin.Due to suboptimal exposures, once-daily oral regimens of levofloxacin at both 500 and 750 mg inconsistently led to bactericidal activity and the frequent acquisition of a second-step gyrA mutation in S. pneumoniae isolates already containing a first-step parC mutation. Conversely, once-daily moxifloxacin 400 mg provides exposures that vastly exceed the apparent efficacy breakpoint and did not select for second-step mutants until exposures were decreased 4-fold. As a result of these data and the emerging literature involving mutations in the pneumococcus, caution should be exercised when the respiratory fluoroquinolones are used to treat patients infected with S. pneumoniae suspected of having parC mutations." @default.
• W2114606427 created "2016-06-24" @default.
• W2114606427 creator A5012851930 @default.
• W2114606427 creator A5037643218 @default.
• W2114606427 creator A5088741251 @default.
• W2114606427 date "2006-07-01" @default.
• W2114606427 modified "2023-10-16" @default.
• W2114606427 title "Evaluation of bacterial kill when modelling the bronchopulmonary pharmacokinetic profile of moxifloxacin and levofloxacin against parC-containing isolates of Streptococcus pneumoniae" @default.
• W2114606427 cites W1505626160 @default.
• W2114606427 cites W1819382944 @default.
• W2114606427 cites W1937825829 @default.
• W2114606427 cites W1965142696 @default.
• W2114606427 cites W1981533737 @default.
• W2114606427 cites W1982607879 @default.
• W2114606427 cites W1997811421 @default.
• W2114606427 cites W2009639913 @default.
• W2114606427 cites W2060879405 @default.
• W2114606427 cites W2067770912 @default.
• W2114606427 cites W2079522835 @default.
• W2114606427 cites W2083121487 @default.
• W2114606427 cites W2091058296 @default.
• W2114606427 cites W2106627363 @default.
• W2114606427 cites W2107416305 @default.
• W2114606427 cites W2108322390 @default.
• W2114606427 cites W2108720766 @default.
• W2114606427 cites W2116149498 @default.
• W2114606427 cites W2134499284 @default.
• W2114606427 cites W2138573008 @default.
• W2114606427 cites W2140120113 @default.
• W2114606427 cites W2141135082 @default.
• W2114606427 cites W2151455960 @default.
• W2114606427 cites W2151535903 @default.
• W2114606427 cites W2152872000 @default.
• W2114606427 cites W2162465279 @default.
• W2114606427 cites W2615846557 @default.
• W2114606427 doi "https://doi.org/10.1093/jac/dkl292" @default.
• W2114606427 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16857688" @default.
• W2114606427 hasPublicationYear "2006" @default.
• W2114606427 type Work @default.
• W2114606427 sameAs 2114606427 @default.
• W2114606427 citedByCount "18" @default.
• W2114606427 countsByYear W21146064272012 @default.
• W2114606427 countsByYear W21146064272014 @default.
• W2114606427 countsByYear W21146064272016 @default.
• W2114606427 countsByYear W21146064272018 @default.
• W2114606427 countsByYear W21146064272021 @default.
• W2114606427 crossrefType "journal-article" @default.
• W2114606427 hasAuthorship W2114606427A5012851930 @default.
• W2114606427 hasAuthorship W2114606427A5037643218 @default.
• W2114606427 hasAuthorship W2114606427A5088741251 @default.
• W2114606427 hasConcept C112705442 @default.
• W2114606427 hasConcept C2778663903 @default.
• W2114606427 hasConcept C2778836808 @default.
• W2114606427 hasConcept C2779922871 @default.
• W2114606427 hasConcept C2781253189 @default.
• W2114606427 hasConcept C2781276175 @default.
• W2114606427 hasConcept C3019249092 @default.
• W2114606427 hasConcept C501593827 @default.
• W2114606427 hasConcept C86803240 @default.
• W2114606427 hasConcept C89423630 @default.
• W2114606427 hasConcept C98274493 @default.
• W2114606427 hasConceptScore W2114606427C112705442 @default.
• W2114606427 hasConceptScore W2114606427C2778663903 @default.
• W2114606427 hasConceptScore W2114606427C2778836808 @default.
• W2114606427 hasConceptScore W2114606427C2779922871 @default.
• W2114606427 hasConceptScore W2114606427C2781253189 @default.
• W2114606427 hasConceptScore W2114606427C2781276175 @default.
• W2114606427 hasConceptScore W2114606427C3019249092 @default.
• W2114606427 hasConceptScore W2114606427C501593827 @default.
• W2114606427 hasConceptScore W2114606427C86803240 @default.
• W2114606427 hasConceptScore W2114606427C89423630 @default.
• W2114606427 hasConceptScore W2114606427C98274493 @default.
• W2114606427 hasIssue "3" @default.
• W2114606427 hasLocation W21146064271 @default.
• W2114606427 hasLocation W21146064272 @default.
• W2114606427 hasOpenAccess W2114606427 @default.
• W2114606427 hasPrimaryLocation W21146064271 @default.
• W2114606427 hasRelatedWork W2010178139 @default.
• W2114606427 hasRelatedWork W2060556654 @default.
• W2114606427 hasRelatedWork W2092074586 @default.
• W2114606427 hasRelatedWork W2101350071 @default.
• W2114606427 hasRelatedWork W2114606427 @default.
• W2114606427 hasRelatedWork W2132466261 @default.
• W2114606427 hasRelatedWork W2147917069 @default.
• W2114606427 hasRelatedWork W2166194120 @default.
• W2114606427 hasRelatedWork W2413847811 @default.
• W2114606427 hasRelatedWork W2415840227 @default.
• W2114606427 hasVolume "58" @default.
• W2114606427 isParatext "false" @default.
• W2114606427 isRetracted "false" @default.
• W2114606427 magId "2114606427" @default.
• W2114606427 workType "article" @default.