Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114619116> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2114619116 abstract "Antisense oligonucleotides (AS ONs) are a powerful means to inhibit the expression of specific genes, but their effectiveness is limited by factors including cellular delivery, biochemical attack, and poor binding to target. We have developed a systems model of the processes required for an antisense oligonucleotide to be successfully delivered and to exert activity in a cell. The model demonstrates a sensitive dependence of the extent of gene expression inhibition on the binding rate for the ON-mRNA interaction. We have focused on the binding event and developed a molecular thermodynamic model based on ON and mRNA folding that predicts accurately the affinity of ON-mRNA binding, and we have observed experimentally that affinity correlates directly with binding rate for these species. Most importantly, we have found that the model successfully selects those ONs that are most successful in cell culture. Taken together, these tools may help accelerate the development of this promising technology." @default.
- W2114619116 created "2016-06-24" @default.
- W2114619116 creator A5055455454 @default.
- W2114619116 date "2003-11-04" @default.
- W2114619116 modified "2023-09-27" @default.
- W2114619116 title "Integrating molecular thermodynamics and systems biology to improve the cellular effectiveness of antisense oligonucleotides" @default.
- W2114619116 cites W2010759469 @default.
- W2114619116 cites W2015649105 @default.
- W2114619116 cites W2017313617 @default.
- W2114619116 cites W2034625697 @default.
- W2114619116 cites W2071446211 @default.
- W2114619116 cites W2072056570 @default.
- W2114619116 doi "https://doi.org/10.1109/nebc.2003.1216042" @default.
- W2114619116 hasPublicationYear "2003" @default.
- W2114619116 type Work @default.
- W2114619116 sameAs 2114619116 @default.
- W2114619116 citedByCount "0" @default.
- W2114619116 crossrefType "proceedings-article" @default.
- W2114619116 hasAuthorship W2114619116A5055455454 @default.
- W2114619116 hasConcept C104317684 @default.
- W2114619116 hasConcept C105580179 @default.
- W2114619116 hasConcept C119599485 @default.
- W2114619116 hasConcept C12554922 @default.
- W2114619116 hasConcept C127413603 @default.
- W2114619116 hasConcept C129312508 @default.
- W2114619116 hasConcept C150194340 @default.
- W2114619116 hasConcept C2776545253 @default.
- W2114619116 hasConcept C54355233 @default.
- W2114619116 hasConcept C70721500 @default.
- W2114619116 hasConcept C86803240 @default.
- W2114619116 hasConcept C95444343 @default.
- W2114619116 hasConceptScore W2114619116C104317684 @default.
- W2114619116 hasConceptScore W2114619116C105580179 @default.
- W2114619116 hasConceptScore W2114619116C119599485 @default.
- W2114619116 hasConceptScore W2114619116C12554922 @default.
- W2114619116 hasConceptScore W2114619116C127413603 @default.
- W2114619116 hasConceptScore W2114619116C129312508 @default.
- W2114619116 hasConceptScore W2114619116C150194340 @default.
- W2114619116 hasConceptScore W2114619116C2776545253 @default.
- W2114619116 hasConceptScore W2114619116C54355233 @default.
- W2114619116 hasConceptScore W2114619116C70721500 @default.
- W2114619116 hasConceptScore W2114619116C86803240 @default.
- W2114619116 hasConceptScore W2114619116C95444343 @default.
- W2114619116 hasLocation W21146191161 @default.
- W2114619116 hasOpenAccess W2114619116 @default.
- W2114619116 hasPrimaryLocation W21146191161 @default.
- W2114619116 hasRelatedWork W1507025540 @default.
- W2114619116 hasRelatedWork W1559190003 @default.
- W2114619116 hasRelatedWork W1560091789 @default.
- W2114619116 hasRelatedWork W1593266148 @default.
- W2114619116 hasRelatedWork W1966868778 @default.
- W2114619116 hasRelatedWork W2040451578 @default.
- W2114619116 hasRelatedWork W2050003729 @default.
- W2114619116 hasRelatedWork W2055808354 @default.
- W2114619116 hasRelatedWork W2064431168 @default.
- W2114619116 hasRelatedWork W2077890213 @default.
- W2114619116 hasRelatedWork W2078190029 @default.
- W2114619116 hasRelatedWork W2137424264 @default.
- W2114619116 hasRelatedWork W2141928906 @default.
- W2114619116 hasRelatedWork W2161620823 @default.
- W2114619116 hasRelatedWork W2174330741 @default.
- W2114619116 hasRelatedWork W2275519973 @default.
- W2114619116 hasRelatedWork W2949580896 @default.
- W2114619116 hasRelatedWork W2997201158 @default.
- W2114619116 hasRelatedWork W3170686805 @default.
- W2114619116 hasRelatedWork W61404373 @default.
- W2114619116 isParatext "false" @default.
- W2114619116 isRetracted "false" @default.
- W2114619116 magId "2114619116" @default.
- W2114619116 workType "article" @default.