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• W2114632318 abstract "The coexistence of potentially aggravating processes is common in asthmatics, particularly in patients with difficult control. The primary aim of this study is to ascertain whether comorbidity is more common in uncontrolled patients. As a secondary aim, we propose to evaluate the correlation between the asthma control test (ACT) and the fraction of exhaled nitric oxide (FENO). A prospective, observational study comparing the function and clinical picture of two groups of asthmatics: controlled (ACT≥20) and uncontrolled (ACT<20). They were all assessed for, smoking, rhinosinusitis, obesity, anxiety, depression, vocal chord dysfunction, gastro-oesophageal reflux (GORD), allergic bronchopulmonary aspergillosis (ABPA), COPD and nasal polyps. A total of 50 patients with controlled asthma and 102 with sub-optimal control were included. The patients with an ACT≥20 had better lung function, less variation in PEF, less bronchial hyper-reactivity and lower FENO values. Comorbidities were found in 95% of the controlled asthmatics and in 97% of the uncontrolled. Only the presence of nasal polyps, GORD and ABPA was more frequent in the uncontrolled group. However, the simultaneous presence of 3 or more comorbidity factors was significantly more frequent in patients with sub-optimal control (P=.01). There was no significant correlation between the FENO and the ACT values (rho=−0.08; P=.32). Aggravating comorbidities are more common in patients with sub-optimal control. There was no correlation between the FENO and the ACT values. La coexistencia de procesos potencialmente agravantes es frecuente en asmáticos, especialmente en individuos con control difícil. Es objetivo primario conocer si la comorbilidad es más frecuente en los pacientes no controlados. Como objetivo secundario nos propusimos evaluar el grado de correlación entre test de control del asma (ACT) y la fracción exhalada de óxido nítrico (FENO). Estudio prospectivo, observacional, que comparó funcional y clínicamente dos grupos de asmáticos: controlados (ACT ≥ 20) y no controlados (ACT < 20). En todos se investigó la presencia de tabaquismo, rinosinusitis, obesidad, ansiedad, depresión, disfunción de cuerdas vocales, reflujo gastroesofágico (RGE), aspergilosis broncopulmonar alérgica (ABPA), EPOC y poliposis nasal. Se incluyeron 56 pacientes con asma controlada y 102 con un control subóptimo. Lós pacientes con un ACT ≥ 20 tenían mejor función pulmonar, menor variabilidad del PEF, menos hiperreactividad bronquial y menores valores de FENO. Se hallaron comorbilidades en el 95% de los asmáticos controlados y en el 97% de los no controlados. Sólo la presencia de poliposis nasal, RGE y ABPA fue más frecuente en el grupo no controlado. Sin embargo, la presencia simultánea de 3 o más factores de comorbilidad fue significativamente más frecuente en los pacientes con un control subóptimo (P = 0,01). No hubo correlación significativa entre los valores del FENO y los del ACT (rho = −0,08; P = 0,32). La suma de comorbilidades agravantes es más frecuente en pacientes con control subóptimo. No existe correlación entre los valores de ACT y de FENO." @default.
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• W2114632318 date "2010-10-01" @default.
• W2114632318 modified "2023-10-17" @default.
• W2114632318 title "Relationship Between Comorbidity and Asthma Control" @default.
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• W2114632318 doi "https://doi.org/10.1016/s1579-2129(11)60003-7" @default.
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