FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114634897> ?p ?o ?g. }

• W2114634897 endingPage "1088" @default.
• W2114634897 startingPage "1081" @default.
• W2114634897 abstract "Lung cancer risk remains elevated for many years after quitting smoking. To assess using proliferation indices in bronchial tissues as an intermediate endpoint biomarker in lung cancer chemoprevention trials, we determined the relationship between the extent, intensity, and cessation of tobacco smoking and proliferative changes in bronchial epithelial biopsy specimens.Bronchial biopsy specimens were obtained from up to six epithelial sites in 120 current smokers (median pack-years, 42) and 207 former smokers (median pack-years, 40; median quit-years, 8.1). Sections from the paraffin-embedded specimens were stained with hematoxylin--eosin to determine the metaplasia index and with an antibody to Ki-67 to determine the proliferative (labeling) index for the basal and parabasal (Ki-67 PLI) layers. All statistical tests were two-sided.Biopsy sites with metaplasia had statistically significantly higher Ki-67-labeling indices than those without metaplasia (P<.001) in both current and former smokers. Increased proliferation was observed in multiple biopsy sites, with the average Ki-67 PLI of the subject strongly correlating with the metaplasia index (r =.72 for current smokers; P<.001), even in sites without metaplasia (r =.23 for current smokers; P<.001). In current smokers, the Ki-67 PLI was associated with the number of packs smoked/day (P =.02) but not with smoking years or pack-years. In subjects who had quit smoking, the Ki-67 PLI dropped statistically significantly within 1 year (P =.008) but remained detectable for more than 20 years, even in the absence of squamous metaplasia.Smoking appears to elicit a dose-related proliferative response in the bronchial epithelia of active smokers. Although the proliferative response decreased gradually in former smokers, a subset of individuals had detectable proliferation for many years and may benefit from targeted chemoprevention. Bronchial epithelial proliferation, measured by Ki-67, may provide a useful biomarker in the assessment of lung cancer risk and in the response to chemopreventive interventions." @default.
• W2114634897 created "2016-06-24" @default.
• W2114634897 creator A5020414083 @default.
• W2114634897 creator A5030797960 @default.
• W2114634897 creator A5053021930 @default.
• W2114634897 creator A5055974749 @default.
• W2114634897 creator A5059550832 @default.
• W2114634897 creator A5059710197 @default.
• W2114634897 creator A5065839430 @default.
• W2114634897 creator A5073876235 @default.
• W2114634897 creator A5075931431 @default.
• W2114634897 creator A5083051785 @default.
• W2114634897 creator A5085188591 @default.
• W2114634897 creator A5088436268 @default.
• W2114634897 date "2001-07-18" @default.
• W2114634897 modified "2023-10-18" @default.
• W2114634897 title "Long-Term Impact of Smoking on Lung Epithelial Proliferation in Current and Former Smokers" @default.
• W2114634897 cites W1525444530 @default.
• W2114634897 cites W1974208182 @default.
• W2114634897 cites W1988956834 @default.
• W2114634897 cites W1991949008 @default.
• W2114634897 cites W1994331461 @default.
• W2114634897 cites W1998982181 @default.
• W2114634897 cites W2006626786 @default.
• W2114634897 cites W2010797534 @default.
• W2114634897 cites W2039716238 @default.
• W2114634897 cites W2043470536 @default.
• W2114634897 cites W2046448747 @default.
• W2114634897 cites W2059972525 @default.
• W2114634897 cites W2077030176 @default.
• W2114634897 cites W2096353669 @default.
• W2114634897 cites W2099356009 @default.
• W2114634897 cites W2103602077 @default.
• W2114634897 cites W2114381434 @default.
• W2114634897 cites W2119363473 @default.
• W2114634897 cites W2120341499 @default.
• W2114634897 cites W2125095024 @default.
• W2114634897 cites W2131216236 @default.
• W2114634897 cites W2132696570 @default.
• W2114634897 cites W2135114425 @default.
• W2114634897 cites W2143480475 @default.
• W2114634897 cites W2151782814 @default.
• W2114634897 cites W2176891727 @default.
• W2114634897 cites W2225986165 @default.
• W2114634897 cites W2317242858 @default.
• W2114634897 cites W4244525660 @default.
• W2114634897 cites W4250707679 @default.
• W2114634897 cites W82306716 @default.
• W2114634897 doi "https://doi.org/10.1093/jnci/93.14.1081" @default.
• W2114634897 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11459869" @default.
• W2114634897 hasPublicationYear "2001" @default.
• W2114634897 type Work @default.
• W2114634897 sameAs 2114634897 @default.
• W2114634897 citedByCount "89" @default.
• W2114634897 countsByYear W21146348972012 @default.
• W2114634897 countsByYear W21146348972013 @default.
• W2114634897 countsByYear W21146348972014 @default.
• W2114634897 countsByYear W21146348972015 @default.
• W2114634897 countsByYear W21146348972016 @default.
• W2114634897 countsByYear W21146348972017 @default.
• W2114634897 countsByYear W21146348972018 @default.
• W2114634897 countsByYear W21146348972019 @default.
• W2114634897 countsByYear W21146348972020 @default.
• W2114634897 countsByYear W21146348972021 @default.
• W2114634897 countsByYear W21146348972023 @default.
• W2114634897 crossrefType "journal-article" @default.
• W2114634897 hasAuthorship W2114634897A5020414083 @default.
• W2114634897 hasAuthorship W2114634897A5030797960 @default.
• W2114634897 hasAuthorship W2114634897A5053021930 @default.
• W2114634897 hasAuthorship W2114634897A5055974749 @default.
• W2114634897 hasAuthorship W2114634897A5059550832 @default.
• W2114634897 hasAuthorship W2114634897A5059710197 @default.
• W2114634897 hasAuthorship W2114634897A5065839430 @default.
• W2114634897 hasAuthorship W2114634897A5073876235 @default.
• W2114634897 hasAuthorship W2114634897A5075931431 @default.
• W2114634897 hasAuthorship W2114634897A5083051785 @default.
• W2114634897 hasAuthorship W2114634897A5085188591 @default.
• W2114634897 hasAuthorship W2114634897A5088436268 @default.
• W2114634897 hasBestOaLocation W21146348971 @default.
• W2114634897 hasConcept C121608353 @default.
• W2114634897 hasConcept C125473707 @default.
• W2114634897 hasConcept C126322002 @default.
• W2114634897 hasConcept C142724271 @default.
• W2114634897 hasConcept C204232928 @default.
• W2114634897 hasConcept C2775934546 @default.
• W2114634897 hasConcept C2776256026 @default.
• W2114634897 hasConcept C2776497702 @default.
• W2114634897 hasConcept C2777714996 @default.
• W2114634897 hasConcept C2777751288 @default.
• W2114634897 hasConcept C2778981785 @default.
• W2114634897 hasConcept C2779357193 @default.
• W2114634897 hasConcept C529295009 @default.
• W2114634897 hasConcept C71924100 @default.
• W2114634897 hasConcept C74864618 @default.
• W2114634897 hasConcept C90924648 @default.
• W2114634897 hasConceptScore W2114634897C121608353 @default.
• W2114634897 hasConceptScore W2114634897C125473707 @default.
• W2114634897 hasConceptScore W2114634897C126322002 @default.

• next