FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114642011> ?p ?o ?g. }

• W2114642011 endingPage "H401" @default.
• W2114642011 startingPage "H391" @default.
• W2114642011 abstract "Rat vascular smooth muscle cells (VSMCs) from renal microvessels metabolize 2′,3′-cAMP to 2′-AMP and 3′-AMP, and these AMPs are converted to adenosine that inhibits microvascular VSMC proliferation via A 2B receptors. The goal of this study was to test whether this mechanism also exists in VSMCs from conduit arteries and whether it is similarly expressed in human vs. rat VSMCs. Incubation of rat and human aortic VSMCs with 2′,3′-cAMP concentration-dependently increased levels of 2′-AMP and 3′-AMP in the medium, with a similar absolute increase in 2′-AMP vs. 3′-AMP. In contrast, in human coronary VSMCs, 2′,3′-cAMP increased 2′-AMP levels yet had little effect on 3′-AMP levels. In all cell types, 2′,3′-cAMP increased levels of adenosine, but not 5′-AMP, and 2′,3′-AMP inhibited cell proliferation. Antagonism of A 2B receptors (MRS-1754), but not A 1 (1,3-dipropyl-8-cyclopentylxanthine), A 2A (SCH-58261), or A 3 (VUF-5574) receptors, attenuated the antiproliferative effects of 2′,3′-cAMP. In all cell types, 2′-AMP, 3′-AMP, and 5′-AMP increased adenosine levels, and inhibition of ecto-5′-nucleotidase blocked this effect of 5′-AMP but not that of 2′-AMP nor 3′-AMP. Also, 2′-AMP, 3′-AMP, and 5′-AMP, like 2′,3′-cAMP, exerted antiproliferative effects that were abolished by antagonism of A 2B receptors with MRS-1754. In conclusion, VSMCs from conduit arteries metabolize 2′,3′-cAMP to AMPs, which are metabolized to adenosine. In rat and human aortic VSMCs, both 2′-AMP and 3′-AMP are involved in this process, whereas, in human coronary VSMCs, 2′,3′-cAMP is mainly converted to 2′-AMP. Because adenosine inhibits VSMC proliferation via A 2B receptors, local vascular production of 2′,3′-cAMP may protect conduit arteries from atherosclerosis." @default.
• W2114642011 created "2016-06-24" @default.
• W2114642011 creator A5005780035 @default.
• W2114642011 creator A5011582040 @default.
• W2114642011 creator A5042375385 @default.
• W2114642011 date "2011-08-01" @default.
• W2114642011 modified "2023-09-23" @default.
• W2114642011 title "2′,3′-cAMP, 3′-AMP, and 2′-AMP inhibit human aortic and coronary vascular smooth muscle cell proliferation via A_2B receptors" @default.
• W2114642011 cites W1496842742 @default.
• W2114642011 cites W1578187871 @default.
• W2114642011 cites W1595801567 @default.
• W2114642011 cites W1601251731 @default.
• W2114642011 cites W1603862527 @default.
• W2114642011 cites W1792542720 @default.
• W2114642011 cites W1969552122 @default.
• W2114642011 cites W1980639002 @default.
• W2114642011 cites W1983178617 @default.
• W2114642011 cites W1995223785 @default.
• W2114642011 cites W1995313693 @default.
• W2114642011 cites W2006874274 @default.
• W2114642011 cites W2016703670 @default.
• W2114642011 cites W2026592669 @default.
• W2114642011 cites W2029878445 @default.
• W2114642011 cites W2035719116 @default.
• W2114642011 cites W2066210298 @default.
• W2114642011 cites W2067273207 @default.
• W2114642011 cites W2070539965 @default.
• W2114642011 cites W2076775170 @default.
• W2114642011 cites W2088938054 @default.
• W2114642011 cites W2094205784 @default.
• W2114642011 cites W2095336107 @default.
• W2114642011 cites W2096023405 @default.
• W2114642011 cites W2097686380 @default.
• W2114642011 cites W2098355288 @default.
• W2114642011 cites W2102092792 @default.
• W2114642011 cites W2111736575 @default.
• W2114642011 cites W2112707428 @default.
• W2114642011 cites W2118111133 @default.
• W2114642011 cites W2118249193 @default.
• W2114642011 cites W2123870316 @default.
• W2114642011 cites W2130423705 @default.
• W2114642011 cites W2131146014 @default.
• W2114642011 cites W2137772461 @default.
• W2114642011 cites W2138912059 @default.
• W2114642011 cites W2141006629 @default.
• W2114642011 cites W2142030049 @default.
• W2114642011 cites W2147987494 @default.
• W2114642011 cites W2149115160 @default.
• W2114642011 cites W2151625463 @default.
• W2114642011 cites W2151820589 @default.
• W2114642011 cites W2154934317 @default.
• W2114642011 cites W2160058642 @default.
• W2114642011 cites W2162597610 @default.
• W2114642011 cites W2167282657 @default.
• W2114642011 cites W2336316317 @default.
• W2114642011 cites W29034186 @default.
• W2114642011 doi "https://doi.org/10.1152/ajpheart.00336.2011" @default.
• W2114642011 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3154660" @default.
• W2114642011 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21622827" @default.
• W2114642011 hasPublicationYear "2011" @default.
• W2114642011 type Work @default.
• W2114642011 sameAs 2114642011 @default.
• W2114642011 citedByCount "29" @default.
• W2114642011 countsByYear W21146420112012 @default.
• W2114642011 countsByYear W21146420112013 @default.
• W2114642011 countsByYear W21146420112014 @default.
• W2114642011 countsByYear W21146420112015 @default.
• W2114642011 countsByYear W21146420112016 @default.
• W2114642011 countsByYear W21146420112017 @default.
• W2114642011 countsByYear W21146420112018 @default.
• W2114642011 countsByYear W21146420112019 @default.
• W2114642011 countsByYear W21146420112020 @default.
• W2114642011 countsByYear W21146420112022 @default.
• W2114642011 crossrefType "journal-article" @default.
• W2114642011 hasAuthorship W2114642011A5005780035 @default.
• W2114642011 hasAuthorship W2114642011A5011582040 @default.
• W2114642011 hasAuthorship W2114642011A5042375385 @default.
• W2114642011 hasBestOaLocation W21146420112 @default.
• W2114642011 hasConcept C126322002 @default.
• W2114642011 hasConcept C134018914 @default.
• W2114642011 hasConcept C170493617 @default.
• W2114642011 hasConcept C185592680 @default.
• W2114642011 hasConcept C2776991684 @default.
• W2114642011 hasConcept C2778938600 @default.
• W2114642011 hasConcept C2779395532 @default.
• W2114642011 hasConcept C2992686903 @default.
• W2114642011 hasConcept C67907053 @default.
• W2114642011 hasConcept C71924100 @default.
• W2114642011 hasConcept C86803240 @default.
• W2114642011 hasConceptScore W2114642011C126322002 @default.
• W2114642011 hasConceptScore W2114642011C134018914 @default.
• W2114642011 hasConceptScore W2114642011C170493617 @default.
• W2114642011 hasConceptScore W2114642011C185592680 @default.
• W2114642011 hasConceptScore W2114642011C2776991684 @default.
• W2114642011 hasConceptScore W2114642011C2778938600 @default.
• W2114642011 hasConceptScore W2114642011C2779395532 @default.
• W2114642011 hasConceptScore W2114642011C2992686903 @default.
• W2114642011 hasConceptScore W2114642011C67907053 @default.

• next