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• W2114644502 abstract "<h3>Background</h3> Although brain serotonin transporter (5-HTT) density has been investigated in subjects with a history of major depressive episodes (MDE), there has never been an investigation of brain 5-HTT during a current MDE. Brain 5-HTT binding potential (BP) may have an important role during MDE due to major depressive disorder, because the 5-HTT regulates extracellular 5-HT. The BP is an index of receptor density. Carbon 11–labeled 3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) positron emission tomography (PET) is the first brain imaging technique that can measure the 5-HTT BP in cortical and subcortical brain regions in vivo. The purposes of this study were to investigate 5-HTT BP during MDE and to determine the relationship between 5-HTT BP and negativistic dysfunctional attitudes during MDE. Dysfunctional attitudes are negatively biased assumptions and beliefs regarding oneself, the world, and the future. Our recent publication of increased serotonin₂BP in MDE with severely negativistic dysfunctional attitudes suggests that this subgroup of MDE subjects has very low levels of extracellular serotonin. <h3>Methods</h3> Regional 5-HTT BP was measured in 20 nonsmoking medication-free (≥3 months) depressed subjects and 20 age-matched nonsmoking, medication-free, healthy subjects using [¹¹C]DASB PET. Dysfunctional attitudes were measured using the Dysfunctional Attitudes Scale. <h3>Results</h3> No difference in regional 5-HTT BP was found between MDE and healthy subjects; however, the subgroup of MDE subjects with highly negativistic dysfunctional attitudes had significantly higher 5-HTT BP compared with healthy subjects in brain regions mainly sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, bilateral caudate, and bilateral putamen; average, 21% greater; F_1,26, 5.6-12.2 [<i>P</i>values, .03-.002]). In the MDE subjects, increased 5-HTT BP was strongly associated with more negativistic dysfunctional attitudes in brain regions primarily sampling serotonergic nerve terminals (prefrontal cortex, anterior cingulate, thalamus, caudate, and putamen;<i>r</i> = 0.64-0.74 [<i>P</i>values, .003 to <.001]). <h3>Conclusions</h3> Serotonin transporters play an important role during depression. The magnitude of regional 5-HTT BP can provide a vulnerability to low levels of extracellular serotonin and symptoms of extremely negativistic dysfunctional attitudes." @default.
• W2114644502 created "2016-06-24" @default.
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• W2114644502 date "2004-12-01" @default.
• W2114644502 modified "2023-09-28" @default.
• W2114644502 title "Brain Serotonin Transporter Binding Potential Measured With Carbon11–Labeled DASB Positron Emission Tomography" @default.
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• W2114644502 doi "https://doi.org/10.1001/archpsyc.61.12.1271" @default.
• W2114644502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15583118" @default.
• W2114644502 hasPublicationYear "2004" @default.
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