FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114686103> ?p ?o ?g. }

• W2114686103 endingPage "E79" @default.
• W2114686103 startingPage "E68" @default.
• W2114686103 abstract "Very-low-density lipoprotein receptor (VLDLR) is a member of the low-density receptor family, highly expressed in adipose tissue, heart, and skeletal muscle. It binds apolipoprotein E-triglyceride-rich lipoproteins and plays a significant role in triglyceride metabolism. PPARgamma is a primary regulator of lipid metabolism in adipocytes and controls the expression of an array of genes involved in lipid trafficking in adipocytes. However, it is not known whether VLDLR is also under the control of PPARgamma. In this study, we investigated the role of PPARgamma in the regulation of VLDLR expression and function in vivo and in vitro. During the differentiation of 3T3-L1 preadipocytes, the levels of VLDLR protein and mRNA increased in parallel with the induction of PPARgamma expression and reached maximum in mature adipocytes. Treatment of differentiated adipocytes with PPARgamma agonist pioglitazone upregulated VLDLR expression in dose- and time-dependent manners. In contrast, specific inhibition of PPARgamma significantly downregulated the protein level of VLDLR. Induction of VLDLR is also demonstrated in vivo in adipose tissue of wild-type (WT) mice treated with pioglitazone. In addition, pioglitazone increased plasma triglyceride-rich lipoprotein clearance and increased epididymal fat mass in WT mice but failed to induce similar effects in vldlr(-/-) mice. These results were further corroborated by the finding that pioglitazone treatment enhanced adipogenesis and lipid deposition in preadipocytes of WT mice, while its effect in VLDLR-null preadipocytes was significantly blunted. These findings provide direct evidence that VLDLR expression is regulated by PPARgamma and contributes in lipid uptake and adipogenesis." @default.
• W2114686103 created "2016-06-24" @default.
• W2114686103 creator A5003734999 @default.
• W2114686103 creator A5026955133 @default.
• W2114686103 creator A5073114114 @default.
• W2114686103 creator A5082242825 @default.
• W2114686103 date "2010-01-01" @default.
• W2114686103 modified "2023-10-17" @default.
• W2114686103 title "Peroxisome proliferator-activated receptor-γ regulates the expression and function of very-low-density lipoprotein receptor" @default.
• W2114686103 cites W1504753880 @default.
• W2114686103 cites W1518800815 @default.
• W2114686103 cites W1526978170 @default.
• W2114686103 cites W1544610401 @default.
• W2114686103 cites W1600667984 @default.
• W2114686103 cites W1672804368 @default.
• W2114686103 cites W1930735427 @default.
• W2114686103 cites W1968856381 @default.
• W2114686103 cites W1970312964 @default.
• W2114686103 cites W1970522333 @default.
• W2114686103 cites W1976137262 @default.
• W2114686103 cites W1978801803 @default.
• W2114686103 cites W1982164579 @default.
• W2114686103 cites W1982385767 @default.
• W2114686103 cites W1986169973 @default.
• W2114686103 cites W2023010330 @default.
• W2114686103 cites W2023097850 @default.
• W2114686103 cites W2033204507 @default.
• W2114686103 cites W2037094605 @default.
• W2114686103 cites W2047465218 @default.
• W2114686103 cites W2050168475 @default.
• W2114686103 cites W2059120300 @default.
• W2114686103 cites W2070283156 @default.
• W2114686103 cites W2071692398 @default.
• W2114686103 cites W2071871820 @default.
• W2114686103 cites W2072753239 @default.
• W2114686103 cites W2074424559 @default.
• W2114686103 cites W2079396188 @default.
• W2114686103 cites W2082749260 @default.
• W2114686103 cites W2097511872 @default.
• W2114686103 cites W2106613328 @default.
• W2114686103 cites W2107277218 @default.
• W2114686103 cites W2109896814 @default.
• W2114686103 cites W2114528799 @default.
• W2114686103 cites W2114604793 @default.
• W2114686103 cites W2116195062 @default.
• W2114686103 cites W2121731956 @default.
• W2114686103 cites W2122252892 @default.
• W2114686103 cites W2125257974 @default.
• W2114686103 cites W2131578695 @default.
• W2114686103 cites W2131755497 @default.
• W2114686103 cites W2132304476 @default.
• W2114686103 cites W2140902312 @default.
• W2114686103 cites W2160942744 @default.
• W2114686103 cites W2402457099 @default.
• W2114686103 cites W2404445223 @default.
• W2114686103 cites W4248953039 @default.
• W2114686103 doi "https://doi.org/10.1152/ajpendo.00367.2009" @default.
• W2114686103 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2806108" @default.
• W2114686103 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19861583" @default.
• W2114686103 hasPublicationYear "2010" @default.
• W2114686103 type Work @default.
• W2114686103 sameAs 2114686103 @default.
• W2114686103 citedByCount "50" @default.
• W2114686103 countsByYear W21146861032012 @default.
• W2114686103 countsByYear W21146861032013 @default.
• W2114686103 countsByYear W21146861032014 @default.
• W2114686103 countsByYear W21146861032016 @default.
• W2114686103 countsByYear W21146861032017 @default.
• W2114686103 countsByYear W21146861032018 @default.
• W2114686103 countsByYear W21146861032019 @default.
• W2114686103 countsByYear W21146861032020 @default.
• W2114686103 countsByYear W21146861032021 @default.
• W2114686103 countsByYear W21146861032022 @default.
• W2114686103 countsByYear W21146861032023 @default.
• W2114686103 crossrefType "journal-article" @default.
• W2114686103 hasAuthorship W2114686103A5003734999 @default.
• W2114686103 hasAuthorship W2114686103A5026955133 @default.
• W2114686103 hasAuthorship W2114686103A5073114114 @default.
• W2114686103 hasAuthorship W2114686103A5082242825 @default.
• W2114686103 hasBestOaLocation W21146861032 @default.
• W2114686103 hasConcept C104317684 @default.
• W2114686103 hasConcept C122927707 @default.
• W2114686103 hasConcept C126322002 @default.
• W2114686103 hasConcept C127561419 @default.
• W2114686103 hasConcept C134018914 @default.
• W2114686103 hasConcept C170493617 @default.
• W2114686103 hasConcept C171089720 @default.
• W2114686103 hasConcept C185592680 @default.
• W2114686103 hasConcept C187345961 @default.
• W2114686103 hasConcept C2777180221 @default.
• W2114686103 hasConcept C2778163477 @default.
• W2114686103 hasConcept C2778384471 @default.
• W2114686103 hasConcept C2778913445 @default.
• W2114686103 hasConcept C2780072125 @default.
• W2114686103 hasConcept C4733338 @default.
• W2114686103 hasConcept C55493867 @default.
• W2114686103 hasConcept C555293320 @default.
• W2114686103 hasConcept C71924100 @default.

• next