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- W2114689251 abstract "Abstract Bacterial lipopolysaccharide (LPS) and prostaglandins (PG) E 2 and F 2α are putative activators of the hypothalamo-pituitary-adrenal axis. Certain of the biological effects of LPS may be mediated by cytokines such as interleukin-1β (IL-1β), while IL-1β itself may operate via induction of the prostaglandins and/or nerve growth factor (NGF). As IL-1β stimulates the release of corticotrophin-releasing hormone (CRH) from acute rat hypothalamic explants directly, the effects of these substances on the release of CRH in vitro were investigated in short- and medium-term (20 and 60 min) incubations. The effect of LPS on the release of PGE 2 and PGF 2α from these explants, as well as from cortical astrocyte cultures, was also studied. LPS did not modify the release of CRH, PGE 2 or PGF 2α in 20-min incubations. In 60-min incubations, LPS stimulated the release of PGE 2 , whereas the release of CRH was weakly, but significantly, reduced; PGF 2α was not altered. PGE 2 significantly stimulated CRH release in the 60-min but not in the 20-min experiments. This effect appeared to be selective for PGE 2 , since PGF 2α did not modify CRH release, alone or in combination. LPS also selectively released PGE 2 but not PGF 2α from cortical astrocyte cultures after 24-h incubation. NGF had no effect on the release of explant CRH, regardless of the length of incubation. It was concluded that neither LPS nor NGF acutely stimulate the hypothalamo-pituitary-adrenal axis by a direct action on hypothalamic CRH, while hypothalamic PGE 2 may mediate, at least in part, certain of the neuroendocrine responses to LPS. Journal of Endocrinology (1994) 140, 103–109" @default.
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- W2114689251 date "1994-01-01" @default.
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- W2114689251 title "Lipopolysaccharide modulation of eicosanoid and corticotrophin-releasing hormone release from rat hypothalamic explants and astrocyte cultures in vitro: evidence for the involvement of prostaglandin E2 but not prostaglandin F2α and lack of effect of nerve growth factor" @default.
- W2114689251 doi "https://doi.org/10.1677/joe.0.1400103" @default.
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