Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114695617> ?p ?o ?g. }
- W2114695617 endingPage "1018" @default.
- W2114695617 startingPage "1005" @default.
- W2114695617 abstract "Specific HLA molecules have recently been shown to confer target cell resistance to lysis by some CD3- natural killer (NK) cells. For certain NK clones, resistance is governed by two specificities (NK1 and NK2) that are associated with particular HLA-C alleles: in general, target cells expressing Cw1, Cw3, Cw7, or Cw8 are susceptible to NK1 but resistant to NK2 clones, whereas target cells expressing Cw2, Cw4, Cw5, or Cw6 are susceptible to NK2 and resistant to NK1 cells. These two clusters of HLA-C alleles are distinguished by a dimorphism in the alpha 1 helical region, localized at amino acid positions 77 and 80. In this report, we show that highly enriched CD3+/CD56- cytotoxic T cell sublines and CD3-/CD56+ NK sublines derived from the same donor have identical cytolytic specificities when tested against a panel of allogeneic LCL and various HLA-B and -C transfectant cell lines. The lysis pattern of the allogeneic cells appeared to be related to the NK2 specificity for both effector cells: LCL expressing HLA-Cw2, Cw4, Cw5, or Cw6 alleles were lysed, while LCL expressing HLA-Cw1, Cw3, or Cw7 molecules were resistant. Resistance to lysis could be conferred to susceptible target cells by transfection with a Cw*0702 gene, while expression of a Cw*0602 gene did not provide protection. Similar patterns of HLA-C-mediated resistance were also found with two polyclonal T cell lines generated from the peripheral blood lymphocytes of unrelated donors. Thus, major histocompatibility complex (MHC) molecules that induced resistance to particular NK cells also regulated target cell resistance to lysis by these non-MHC-restricted effector T cells. For both types of effector cells, direct binding to HLA-C molecules was necessary to achieve inhibition since preincubation with mAb specific for class I molecules destroyed the protection from lysis of HLA-Cw7 expressing target cells. mAbs specific for CD3 and CD8 molecules had no influence on lysis or inhibition of the NK-like T cells. Formation of MHC complexes with particular peptides did not appear to be essential to confer resistance, since a cell line with defective peptide transporter genes (TAP genes), when transfected with an appropriate HLA-C allele, was as resistant to lysis as HLA-C transfectant lines with normal TAP function. These results suggest that HLA-C molecules may deliver negative regulatory signals to some non-MHC-restricted T cells in a manner similar to that described previously for particular NK cells." @default.
- W2114695617 created "2016-06-24" @default.
- W2114695617 creator A5004327073 @default.
- W2114695617 creator A5009178208 @default.
- W2114695617 creator A5066232501 @default.
- W2114695617 date "1995-10-01" @default.
- W2114695617 modified "2023-10-09" @default.
- W2114695617 title "Expression of HLA-C molecules confers target cell resistance to some non-major histocompatibility complex-restricted T cells in a manner analogous to allospecific natural killer cells." @default.
- W2114695617 cites W1483440883 @default.
- W2114695617 cites W1485698381 @default.
- W2114695617 cites W1486183981 @default.
- W2114695617 cites W1506397040 @default.
- W2114695617 cites W1507499449 @default.
- W2114695617 cites W1555513503 @default.
- W2114695617 cites W1555698599 @default.
- W2114695617 cites W1581194007 @default.
- W2114695617 cites W1610828262 @default.
- W2114695617 cites W1637920030 @default.
- W2114695617 cites W1913010334 @default.
- W2114695617 cites W1966187053 @default.
- W2114695617 cites W1968046203 @default.
- W2114695617 cites W1968345966 @default.
- W2114695617 cites W1981441245 @default.
- W2114695617 cites W1983320974 @default.
- W2114695617 cites W1993116214 @default.
- W2114695617 cites W1993334366 @default.
- W2114695617 cites W1996441373 @default.
- W2114695617 cites W1996594154 @default.
- W2114695617 cites W2001852133 @default.
- W2114695617 cites W2005984040 @default.
- W2114695617 cites W2020846586 @default.
- W2114695617 cites W2022576045 @default.
- W2114695617 cites W2024110940 @default.
- W2114695617 cites W2037260212 @default.
- W2114695617 cites W2038545704 @default.
- W2114695617 cites W2041408875 @default.
- W2114695617 cites W2055513503 @default.
- W2114695617 cites W2057312481 @default.
- W2114695617 cites W2059167513 @default.
- W2114695617 cites W2063290750 @default.
- W2114695617 cites W2063580217 @default.
- W2114695617 cites W2064789528 @default.
- W2114695617 cites W2065655449 @default.
- W2114695617 cites W2087795091 @default.
- W2114695617 cites W2088513299 @default.
- W2114695617 cites W2088564222 @default.
- W2114695617 cites W2095991061 @default.
- W2114695617 cites W2096870711 @default.
- W2114695617 cites W2099618881 @default.
- W2114695617 cites W2101283545 @default.
- W2114695617 cites W2104829564 @default.
- W2114695617 cites W2106241062 @default.
- W2114695617 cites W2120549614 @default.
- W2114695617 cites W2122144067 @default.
- W2114695617 cites W2124982785 @default.
- W2114695617 cites W2133109711 @default.
- W2114695617 cites W2146335364 @default.
- W2114695617 cites W2147919674 @default.
- W2114695617 cites W2161165126 @default.
- W2114695617 cites W2192821761 @default.
- W2114695617 cites W2416315200 @default.
- W2114695617 cites W2443976586 @default.
- W2114695617 cites W309166525 @default.
- W2114695617 doi "https://doi.org/10.1084/jem.182.4.1005" @default.
- W2114695617 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2192283" @default.
- W2114695617 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7561674" @default.
- W2114695617 hasPublicationYear "1995" @default.
- W2114695617 type Work @default.
- W2114695617 sameAs 2114695617 @default.
- W2114695617 citedByCount "43" @default.
- W2114695617 countsByYear W21146956172012 @default.
- W2114695617 countsByYear W21146956172013 @default.
- W2114695617 countsByYear W21146956172014 @default.
- W2114695617 countsByYear W21146956172015 @default.
- W2114695617 countsByYear W21146956172017 @default.
- W2114695617 crossrefType "journal-article" @default.
- W2114695617 hasAuthorship W2114695617A5004327073 @default.
- W2114695617 hasAuthorship W2114695617A5009178208 @default.
- W2114695617 hasAuthorship W2114695617A5066232501 @default.
- W2114695617 hasBestOaLocation W21146956171 @default.
- W2114695617 hasConcept C114684123 @default.
- W2114695617 hasConcept C147483822 @default.
- W2114695617 hasConcept C153911025 @default.
- W2114695617 hasConcept C154317977 @default.
- W2114695617 hasConcept C167672396 @default.
- W2114695617 hasConcept C188280979 @default.
- W2114695617 hasConcept C202751555 @default.
- W2114695617 hasConcept C202965653 @default.
- W2114695617 hasConcept C203014093 @default.
- W2114695617 hasConcept C207936829 @default.
- W2114695617 hasConcept C2778102761 @default.
- W2114695617 hasConcept C54355233 @default.
- W2114695617 hasConcept C73588182 @default.
- W2114695617 hasConcept C86803240 @default.
- W2114695617 hasConceptScore W2114695617C114684123 @default.
- W2114695617 hasConceptScore W2114695617C147483822 @default.
- W2114695617 hasConceptScore W2114695617C153911025 @default.
- W2114695617 hasConceptScore W2114695617C154317977 @default.