Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114701433> ?p ?o ?g. }
- W2114701433 endingPage "2040" @default.
- W2114701433 startingPage "2030" @default.
- W2114701433 abstract "Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related behaviors using H3R knockout (KO) mice and ligands. H3R KO mice consumed less alcohol than wild-type (WT) mice in a two-bottle free-choice test and in a 'drinking in the dark' model. H3R antagonist ciproxifan suppressed and H3R agonist immepip increased alcohol drinking in C57BL/6J mice. Impairment in reward mechanisms in H3R KO mice was confirmed by the lack of alcohol-evoked conditioned place preference. Plasma alcohol concentrations of H3R KO and WT mice were similar. There were no marked differences in brain biogenic amine levels in H3R KO mice compared with the control animals after alcohol drinking. In conclusion, the findings of this study provide evidence for the role of H3R receptor in alcohol-related behaviors, especially in alcohol drinking and alcohol reward. Thus, targeting H3Rs with a specific antagonist might be a potential means to treat alcoholism in the future." @default.
- W2114701433 created "2016-06-24" @default.
- W2114701433 creator A5007449876 @default.
- W2114701433 creator A5013795857 @default.
- W2114701433 creator A5014800650 @default.
- W2114701433 creator A5020216776 @default.
- W2114701433 creator A5021482273 @default.
- W2114701433 creator A5061176617 @default.
- W2114701433 date "2011-06-08" @default.
- W2114701433 modified "2023-10-18" @default.
- W2114701433 title "Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice" @default.
- W2114701433 cites W1524949005 @default.
- W2114701433 cites W1878860530 @default.
- W2114701433 cites W1970028894 @default.
- W2114701433 cites W1977549232 @default.
- W2114701433 cites W1981298128 @default.
- W2114701433 cites W1984308291 @default.
- W2114701433 cites W1993640624 @default.
- W2114701433 cites W1995291346 @default.
- W2114701433 cites W1996815356 @default.
- W2114701433 cites W2008449348 @default.
- W2114701433 cites W2008663019 @default.
- W2114701433 cites W2012953094 @default.
- W2114701433 cites W2018056485 @default.
- W2114701433 cites W2021876207 @default.
- W2114701433 cites W2022628868 @default.
- W2114701433 cites W2022868683 @default.
- W2114701433 cites W2026668588 @default.
- W2114701433 cites W2038566061 @default.
- W2114701433 cites W2040080531 @default.
- W2114701433 cites W2053863531 @default.
- W2114701433 cites W2057104160 @default.
- W2114701433 cites W2059581034 @default.
- W2114701433 cites W2064144048 @default.
- W2114701433 cites W2064577419 @default.
- W2114701433 cites W2065448466 @default.
- W2114701433 cites W2073821618 @default.
- W2114701433 cites W2077687762 @default.
- W2114701433 cites W2080186455 @default.
- W2114701433 cites W2092781217 @default.
- W2114701433 cites W2102773142 @default.
- W2114701433 cites W2123035658 @default.
- W2114701433 cites W2130270464 @default.
- W2114701433 cites W2137603696 @default.
- W2114701433 cites W2152452311 @default.
- W2114701433 cites W2168343236 @default.
- W2114701433 cites W74595266 @default.
- W2114701433 doi "https://doi.org/10.1038/npp.2011.90" @default.
- W2114701433 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3158320" @default.
- W2114701433 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21654737" @default.
- W2114701433 hasPublicationYear "2011" @default.
- W2114701433 type Work @default.
- W2114701433 sameAs 2114701433 @default.
- W2114701433 citedByCount "40" @default.
- W2114701433 countsByYear W21147014332012 @default.
- W2114701433 countsByYear W21147014332013 @default.
- W2114701433 countsByYear W21147014332014 @default.
- W2114701433 countsByYear W21147014332015 @default.
- W2114701433 countsByYear W21147014332016 @default.
- W2114701433 countsByYear W21147014332017 @default.
- W2114701433 countsByYear W21147014332018 @default.
- W2114701433 countsByYear W21147014332019 @default.
- W2114701433 countsByYear W21147014332020 @default.
- W2114701433 countsByYear W21147014332021 @default.
- W2114701433 countsByYear W21147014332022 @default.
- W2114701433 countsByYear W21147014332023 @default.
- W2114701433 crossrefType "journal-article" @default.
- W2114701433 hasAuthorship W2114701433A5007449876 @default.
- W2114701433 hasAuthorship W2114701433A5013795857 @default.
- W2114701433 hasAuthorship W2114701433A5014800650 @default.
- W2114701433 hasAuthorship W2114701433A5020216776 @default.
- W2114701433 hasAuthorship W2114701433A5021482273 @default.
- W2114701433 hasAuthorship W2114701433A5061176617 @default.
- W2114701433 hasBestOaLocation W21147014331 @default.
- W2114701433 hasConcept C1122143 @default.
- W2114701433 hasConcept C134018914 @default.
- W2114701433 hasConcept C170493617 @default.
- W2114701433 hasConcept C185592680 @default.
- W2114701433 hasConcept C2776885963 @default.
- W2114701433 hasConcept C2778938600 @default.
- W2114701433 hasConcept C2781066024 @default.
- W2114701433 hasConcept C55493867 @default.
- W2114701433 hasConcept C63180777 @default.
- W2114701433 hasConcept C71924100 @default.
- W2114701433 hasConcept C98274493 @default.
- W2114701433 hasConceptScore W2114701433C1122143 @default.
- W2114701433 hasConceptScore W2114701433C134018914 @default.
- W2114701433 hasConceptScore W2114701433C170493617 @default.
- W2114701433 hasConceptScore W2114701433C185592680 @default.
- W2114701433 hasConceptScore W2114701433C2776885963 @default.
- W2114701433 hasConceptScore W2114701433C2778938600 @default.
- W2114701433 hasConceptScore W2114701433C2781066024 @default.
- W2114701433 hasConceptScore W2114701433C55493867 @default.
- W2114701433 hasConceptScore W2114701433C63180777 @default.
- W2114701433 hasConceptScore W2114701433C71924100 @default.
- W2114701433 hasConceptScore W2114701433C98274493 @default.
- W2114701433 hasIssue "10" @default.
- W2114701433 hasLocation W21147014331 @default.