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- W2114714514 abstract "The in vivo pharmacological and toxicological investigation of biodegradable ion exchange resin was carried out to provide evidence for further clinical utilizations. Acute toxicity study, general pharmacological studies, hemolytic experiments, systemic hypersensitivity experiments and vascular stimulation experiments were conducted. The general pharmacological effects of the biodegradable ion exchange resin on the nervous system of mice, the functional coordination of mice, the hypnosis of mice treated with nembutal at subliminal dose, the autonomic activities of tested mice, and the heart rate, blood pressure, electrocardiograph (ECG) and breathing of the anesthetic cats. The LD50 of biodegradable ion exchange resin to mice by tail intravenous injection was 129.37 mg kg-1, and the 95% credible limit was 121.65 ~ 137.58 mg kg-1. The biodegradable ion exchange resin did not have significant influence on the animals in the general pharmacological studies in the experimental conditions described in this study. Besides, the biodegradable ion exchange resin did not have hemolytic and erythrocyte aggregate effect and was qualified for allergy test under the dose condition in this experiment. Neither did it have obvious irritant effect on the blood vessels of rabbit ears. The desirable pharmacological and toxicological behaviors of the biodegradable ion exchange resin exhibited indicated that this novel formulation had great biocompatibility and had great potential for clinical utilizations. Key words: Pharmacology, toxicology, biodegradable ion exchange resin, biocompatibility." @default.
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- W2114714514 date "2014-07-29" @default.
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- W2114714514 title "Biocompatibility research of a novel biodegradable ion exchange resin" @default.
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- W2114714514 doi "https://doi.org/10.5897/ajpp12.1220" @default.
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