FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114722175> ?p ?o ?g. }

• W2114722175 endingPage "1251" @default.
• W2114722175 startingPage "1243" @default.
• W2114722175 abstract "The objectives of this study were to determine whether a synergistic effect could be obtained in vitro between bovine lactoferricin (B-LFcin) and antibiotics against Pseudomonas aeruginosa and Staphylococcus aureus isolates from ocular infections, and to evaluate the use of B-LFcin as an adjunct to the antibiotic treatment of corneal infection in vivo.Chequerboard and time-kill assays were performed to investigate the combined effects of B-LFcin and conventional antibiotics, including ciprofloxacin, ceftazidime and gentamicin, against 17 strains of P. aeruginosa (8) and S. aureus (9) isolated from ocular infection and inflammation, and 1 reference strain of S. aureus. Corneas of C57BL/6 mice were topically challenged with a multidrug-resistant strain of P. aeruginosa. Nine hours post-challenge, mice were treated topically and hourly with either vehicle, B-LFcin, ciprofloxacin or ciprofloxacin containing B-LFcin for 8 h. Corneas were then clinically examined, and bacterial numbers and levels of myeloperoxidase (MPO) evaluated.Synergy between B-LFcin and ciprofloxacin or ceftazidime was identified in most P. aeruginosa isolates, including multidrug-resistant strains, whereas no synergistic effect was seen between B-LFcin and gentamicin. Synergy was only observed with B-LFcin and ciprofloxacin against 2/10 S. aureus strains, and there was no synergy between B-LFcin and any of the other antibiotics tested. Combined B-LFcin and ciprofloxacin treatment significantly improved the clinical outcome, and reduced bacterial numbers and MPO in infected mouse corneas. B-LFcin alone was also able to reduce levels of MPO in infected corneas.These findings indicate that B-LFcin may have advantages as an adjunct therapy with both antimicrobial and anti-inflammatory properties in the treatment of corneal infection." @default.
• W2114722175 created "2016-06-24" @default.
• W2114722175 creator A5001592129 @default.
• W2114722175 creator A5014638202 @default.
• W2114722175 creator A5054628624 @default.
• W2114722175 creator A5059437213 @default.
• W2114722175 creator A5064284841 @default.
• W2114722175 date "2010-04-07" @default.
• W2114722175 modified "2023-10-01" @default.
• W2114722175 title "Evaluation of synergistic activity of bovine lactoferricin with antibiotics in corneal infection" @default.
• W2114722175 cites W1507181797 @default.
• W2114722175 cites W16631805 @default.
• W2114722175 cites W1789475526 @default.
• W2114722175 cites W1808348270 @default.
• W2114722175 cites W1839089261 @default.
• W2114722175 cites W1930907986 @default.
• W2114722175 cites W1964763686 @default.
• W2114722175 cites W1989998611 @default.
• W2114722175 cites W1997357193 @default.
• W2114722175 cites W2002669023 @default.
• W2114722175 cites W2015211917 @default.
• W2114722175 cites W2016562927 @default.
• W2114722175 cites W2025801951 @default.
• W2114722175 cites W2028480288 @default.
• W2114722175 cites W2030162048 @default.
• W2114722175 cites W2030446436 @default.
• W2114722175 cites W2035168471 @default.
• W2114722175 cites W2037823432 @default.
• W2114722175 cites W2046438451 @default.
• W2114722175 cites W2055265060 @default.
• W2114722175 cites W2069928195 @default.
• W2114722175 cites W2070150908 @default.
• W2114722175 cites W2070688623 @default.
• W2114722175 cites W2075831247 @default.
• W2114722175 cites W2083312383 @default.
• W2114722175 cites W2090194331 @default.
• W2114722175 cites W2098695824 @default.
• W2114722175 cites W2106026809 @default.
• W2114722175 cites W2106879357 @default.
• W2114722175 cites W2114458161 @default.
• W2114722175 cites W2119227971 @default.
• W2114722175 cites W2124419654 @default.
• W2114722175 cites W2128929376 @default.
• W2114722175 cites W2130213902 @default.
• W2114722175 cites W2131192673 @default.
• W2114722175 cites W2132034405 @default.
• W2114722175 cites W2133041006 @default.
• W2114722175 cites W2134209889 @default.
• W2114722175 cites W2137878856 @default.
• W2114722175 cites W2140424229 @default.
• W2114722175 cites W2141256862 @default.
• W2114722175 cites W2151627786 @default.
• W2114722175 cites W2155930383 @default.
• W2114722175 cites W2168252594 @default.
• W2114722175 doi "https://doi.org/10.1093/jac/dkq106" @default.
• W2114722175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20375033" @default.
• W2114722175 hasPublicationYear "2010" @default.
• W2114722175 type Work @default.
• W2114722175 sameAs 2114722175 @default.
• W2114722175 citedByCount "68" @default.
• W2114722175 countsByYear W21147221752012 @default.
• W2114722175 countsByYear W21147221752013 @default.
• W2114722175 countsByYear W21147221752014 @default.
• W2114722175 countsByYear W21147221752015 @default.
• W2114722175 countsByYear W21147221752016 @default.
• W2114722175 countsByYear W21147221752017 @default.
• W2114722175 countsByYear W21147221752018 @default.
• W2114722175 countsByYear W21147221752019 @default.
• W2114722175 countsByYear W21147221752020 @default.
• W2114722175 countsByYear W21147221752021 @default.
• W2114722175 countsByYear W21147221752022 @default.
• W2114722175 countsByYear W21147221752023 @default.
• W2114722175 crossrefType "journal-article" @default.
• W2114722175 hasAuthorship W2114722175A5001592129 @default.
• W2114722175 hasAuthorship W2114722175A5014638202 @default.
• W2114722175 hasAuthorship W2114722175A5054628624 @default.
• W2114722175 hasAuthorship W2114722175A5059437213 @default.
• W2114722175 hasAuthorship W2114722175A5064284841 @default.
• W2114722175 hasBestOaLocation W21147221751 @default.
• W2114722175 hasConcept C2775832221 @default.
• W2114722175 hasConcept C2776968632 @default.
• W2114722175 hasConcept C2777637488 @default.
• W2114722175 hasConcept C2778512257 @default.
• W2114722175 hasConcept C2779489039 @default.
• W2114722175 hasConcept C3019249092 @default.
• W2114722175 hasConcept C501593827 @default.
• W2114722175 hasConcept C523546767 @default.
• W2114722175 hasConcept C54355233 @default.
• W2114722175 hasConcept C71924100 @default.
• W2114722175 hasConcept C86803240 @default.
• W2114722175 hasConcept C89423630 @default.
• W2114722175 hasConceptScore W2114722175C2775832221 @default.
• W2114722175 hasConceptScore W2114722175C2776968632 @default.
• W2114722175 hasConceptScore W2114722175C2777637488 @default.
• W2114722175 hasConceptScore W2114722175C2778512257 @default.
• W2114722175 hasConceptScore W2114722175C2779489039 @default.
• W2114722175 hasConceptScore W2114722175C3019249092 @default.
• W2114722175 hasConceptScore W2114722175C501593827 @default.

• next