FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114729904> ?p ?o ?g. }

• W2114729904 endingPage "2361" @default.
• W2114729904 startingPage "2347" @default.
• W2114729904 abstract "Neurodegenerative disorders, such as Huntington's, Alzheimer's, and Parkinson's diseases, affect millions of people worldwide and currently there are few effective treatments and no cures for these diseases. Transgenic mice expressing human transgenes for huntingtin, amyloid precursor protein, and other genes associated with familial forms of neurodegenerative disease in humans provide remarkable tools for studying neurodegeneration because they mimic many of the pathological and behavioural features of the human conditions. One of the recurring themes revealed by these various transgenic models is that different diseases may share similar molecular and cellular mechanisms of pathogenesis. Cellular mechanisms known to be disrupted at early stages in multiple neurodegenerative disorders include gene expression, protein interactions (manifesting as pathological protein aggregation and disrupted signaling), synaptic function and plasticity. Recent work in mouse models of Huntington's disease has shown that enriching the environment of transgenic animals delays the onset and slows the progression of Huntington's disease‐associated motor and cognitive symptoms. Environmental enrichment is known to induce various molecular and cellular changes in specific brain regions of wild‐type animals, including altered gene expression profiles, enhanced neurogenesis and synaptic plasticity. The promising effects of environmental stimulation, demonstrated recently in models of neurodegenerative disease, suggest that therapy based on the principles of environmental enrichment might benefit disease sufferers and provide insight into possible mechanisms of neurodegeneration and subsequent identification of novel therapeutic targets. Here, we review the studies of environmental enrichment relevant to some major neurodegenerative diseases and discuss their research and clinical implications." @default.
• W2114729904 created "2016-06-24" @default.
• W2114729904 creator A5028204229 @default.
• W2114729904 creator A5052976583 @default.
• W2114729904 date "2005-04-22" @default.
• W2114729904 modified "2023-10-17" @default.
• W2114729904 title "Nature, nurture and neurology: gene-environment interactions in neurodegenerative disease" @default.
• W2114729904 cites W1488872763 @default.
• W2114729904 cites W1496088120 @default.
• W2114729904 cites W1504584187 @default.
• W2114729904 cites W1546721168 @default.
• W2114729904 cites W1639255528 @default.
• W2114729904 cites W1886575365 @default.
• W2114729904 cites W188973668 @default.
• W2114729904 cites W1968151995 @default.
• W2114729904 cites W1968260559 @default.
• W2114729904 cites W1972251644 @default.
• W2114729904 cites W1972273654 @default.
• W2114729904 cites W1973055895 @default.
• W2114729904 cites W1973191842 @default.
• W2114729904 cites W1973855353 @default.
• W2114729904 cites W1974759530 @default.
• W2114729904 cites W1974989152 @default.
• W2114729904 cites W1982645514 @default.
• W2114729904 cites W1984200333 @default.
• W2114729904 cites W1984322190 @default.
• W2114729904 cites W1985131940 @default.
• W2114729904 cites W1985474993 @default.
• W2114729904 cites W1987135509 @default.
• W2114729904 cites W1987446689 @default.
• W2114729904 cites W1987925748 @default.
• W2114729904 cites W1990115112 @default.
• W2114729904 cites W1992222970 @default.
• W2114729904 cites W1992841111 @default.
• W2114729904 cites W1995785495 @default.
• W2114729904 cites W1997887740 @default.
• W2114729904 cites W1998994558 @default.
• W2114729904 cites W1999631936 @default.
• W2114729904 cites W2004969253 @default.
• W2114729904 cites W2005170723 @default.
• W2114729904 cites W2005659388 @default.
• W2114729904 cites W2006129024 @default.
• W2114729904 cites W2008937138 @default.
• W2114729904 cites W2014497513 @default.
• W2114729904 cites W2015241097 @default.
• W2114729904 cites W2018686642 @default.
• W2114729904 cites W2022829791 @default.
• W2114729904 cites W2024570377 @default.
• W2114729904 cites W2025774809 @default.
• W2114729904 cites W2026124745 @default.
• W2114729904 cites W2026179327 @default.
• W2114729904 cites W2027500465 @default.
• W2114729904 cites W2028865828 @default.
• W2114729904 cites W2029486567 @default.
• W2114729904 cites W2030182984 @default.
• W2114729904 cites W2030258195 @default.
• W2114729904 cites W2032920422 @default.
• W2114729904 cites W2034233086 @default.
• W2114729904 cites W2036362108 @default.
• W2114729904 cites W2042716629 @default.
• W2114729904 cites W2043279727 @default.
• W2114729904 cites W2043819042 @default.
• W2114729904 cites W2044107164 @default.
• W2114729904 cites W2044213360 @default.
• W2114729904 cites W2045153164 @default.
• W2114729904 cites W2046209489 @default.
• W2114729904 cites W2047562912 @default.
• W2114729904 cites W2047636024 @default.
• W2114729904 cites W2047902587 @default.
• W2114729904 cites W2053152816 @default.
• W2114729904 cites W2053909216 @default.
• W2114729904 cites W2054264241 @default.
• W2114729904 cites W2054944161 @default.
• W2114729904 cites W2058723245 @default.
• W2114729904 cites W2058873342 @default.
• W2114729904 cites W2060836042 @default.
• W2114729904 cites W2062682951 @default.
• W2114729904 cites W2066128411 @default.
• W2114729904 cites W2067532863 @default.
• W2114729904 cites W2067570041 @default.
• W2114729904 cites W2072038893 @default.
• W2114729904 cites W2074533563 @default.
• W2114729904 cites W2074678189 @default.
• W2114729904 cites W2077009055 @default.
• W2114729904 cites W2079156156 @default.
• W2114729904 cites W2081881251 @default.
• W2114729904 cites W2082732384 @default.
• W2114729904 cites W2084620265 @default.
• W2114729904 cites W2087651523 @default.
• W2114729904 cites W2087814712 @default.
• W2114729904 cites W2090150925 @default.
• W2114729904 cites W2090271811 @default.
• W2114729904 cites W2090390963 @default.
• W2114729904 cites W2093045406 @default.
• W2114729904 cites W2094028504 @default.
• W2114729904 cites W2095123707 @default.
• W2114729904 cites W2096192426 @default.
• W2114729904 cites W2098039927 @default.

• next