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- W2114750354 abstract "The amyloid-beta (Aβ) hypothesis of Alzheimer's disease (AD) causality is now well into its third decade and is finally entering a phase of rigorous clinical testing in numerous late stage clinical trials. The use of Aβ-based animal models of AD has been essential to the discovery and/or preclinical validation of many of these therapeutic approaches. While several neuropathologically based results from preclinical studies have translated nicely into AD patients, the full clinical value of Aβ-directed therapies awaits results from trials now in progress." @default.
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- W2114750354 date "2010-01-01" @default.
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- W2114750354 title "The role of animal models in advancing amyloid-beta immunotherapy to the clinic" @default.
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- W2114750354 doi "https://doi.org/10.1186/alzrt46" @default.
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