FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114764690> ?p ?o ?g. }

• W2114764690 endingPage "922" @default.
• W2114764690 startingPage "912" @default.
• W2114764690 abstract "Endoplasmic reticulum (ER) stress is increased in obesity and is postulated to be a major contributor to many obesity-related pathologies. Little is known about what causes ER stress in obese people. Here, we show that insulin upregulated the unfolded protein response (UPR), an adaptive reaction to ER stress, in vitro in 3T3-L1 adipocytes and in vivo, in subcutaneous (sc) adipose tissue of nondiabetic subjects, where it increased the UPR dose dependently over the entire physiologic insulin range (from ∼35 to ∼1,450 pmol/L). The insulin-induced UPR was not due to increased glucose uptake/metabolism and oxidative stress. It was associated, however, with increased protein synthesis, with accumulation of ubiquitination associated proteins, and with multiple posttranslational protein modifications (acetylations, methylations, nitrosylations, succinylation, and ubiquitinations), some of which are potential causes for ER stress. These results reveal a new physiologic role of insulin and provide a putative mechanism for the development of ER stress in obesity. They may also have clinical and therapeutic implications, e.g., in diabetic patients treated with high doses of insulin." @default.
• W2114764690 created "2016-06-24" @default.
• W2114764690 creator A5004331456 @default.
• W2114764690 creator A5014266583 @default.
• W2114764690 creator A5016543778 @default.
• W2114764690 creator A5023474681 @default.
• W2114764690 creator A5042236983 @default.
• W2114764690 creator A5046913065 @default.
• W2114764690 creator A5054821401 @default.
• W2114764690 creator A5055279293 @default.
• W2114764690 creator A5076854498 @default.
• W2114764690 creator A5083612093 @default.
• W2114764690 creator A5090080754 @default.
• W2114764690 date "2014-02-13" @default.
• W2114764690 modified "2023-10-17" @default.
• W2114764690 title "Insulin Regulates the Unfolded Protein Response in Human Adipose Tissue" @default.
• W2114764690 cites W1964443702 @default.
• W2114764690 cites W1986596477 @default.
• W2114764690 cites W1996843089 @default.
• W2114764690 cites W2006079218 @default.
• W2114764690 cites W2007078899 @default.
• W2114764690 cites W2014856320 @default.
• W2114764690 cites W2025421578 @default.
• W2114764690 cites W2035145212 @default.
• W2114764690 cites W2035849319 @default.
• W2114764690 cites W2038018821 @default.
• W2114764690 cites W2041007287 @default.
• W2114764690 cites W2044152079 @default.
• W2114764690 cites W2053500970 @default.
• W2114764690 cites W2062663908 @default.
• W2114764690 cites W2062724886 @default.
• W2114764690 cites W2064194224 @default.
• W2114764690 cites W2079643102 @default.
• W2114764690 cites W2080901528 @default.
• W2114764690 cites W2083990676 @default.
• W2114764690 cites W2092244701 @default.
• W2114764690 cites W2094352498 @default.
• W2114764690 cites W2096773810 @default.
• W2114764690 cites W2097626753 @default.
• W2114764690 cites W2100718398 @default.
• W2114764690 cites W2112286580 @default.
• W2114764690 cites W2115366344 @default.
• W2114764690 cites W2122631753 @default.
• W2114764690 cites W2126078160 @default.
• W2114764690 cites W2138336750 @default.
• W2114764690 cites W2138485536 @default.
• W2114764690 cites W2147127785 @default.
• W2114764690 cites W2152187155 @default.
• W2114764690 cites W2153281726 @default.
• W2114764690 cites W2161939149 @default.
• W2114764690 cites W4256602755 @default.
• W2114764690 doi "https://doi.org/10.2337/db13-0906" @default.
• W2114764690 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3931405" @default.
• W2114764690 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24130338" @default.
• W2114764690 hasPublicationYear "2014" @default.
• W2114764690 type Work @default.
• W2114764690 sameAs 2114764690 @default.
• W2114764690 citedByCount "35" @default.
• W2114764690 countsByYear W21147646902014 @default.
• W2114764690 countsByYear W21147646902015 @default.
• W2114764690 countsByYear W21147646902016 @default.
• W2114764690 countsByYear W21147646902017 @default.
• W2114764690 countsByYear W21147646902018 @default.
• W2114764690 countsByYear W21147646902019 @default.
• W2114764690 countsByYear W21147646902020 @default.
• W2114764690 countsByYear W21147646902021 @default.
• W2114764690 countsByYear W21147646902022 @default.
• W2114764690 countsByYear W21147646902023 @default.
• W2114764690 crossrefType "journal-article" @default.
• W2114764690 hasAuthorship W2114764690A5004331456 @default.
• W2114764690 hasAuthorship W2114764690A5014266583 @default.
• W2114764690 hasAuthorship W2114764690A5016543778 @default.
• W2114764690 hasAuthorship W2114764690A5023474681 @default.
• W2114764690 hasAuthorship W2114764690A5042236983 @default.
• W2114764690 hasAuthorship W2114764690A5046913065 @default.
• W2114764690 hasAuthorship W2114764690A5054821401 @default.
• W2114764690 hasAuthorship W2114764690A5055279293 @default.
• W2114764690 hasAuthorship W2114764690A5076854498 @default.
• W2114764690 hasAuthorship W2114764690A5083612093 @default.
• W2114764690 hasAuthorship W2114764690A5090080754 @default.
• W2114764690 hasBestOaLocation W21147646901 @default.
• W2114764690 hasConcept C104317684 @default.
• W2114764690 hasConcept C126322002 @default.
• W2114764690 hasConcept C127561419 @default.
• W2114764690 hasConcept C134018914 @default.
• W2114764690 hasConcept C139447449 @default.
• W2114764690 hasConcept C158617107 @default.
• W2114764690 hasConcept C171089720 @default.
• W2114764690 hasConcept C185592680 @default.
• W2114764690 hasConcept C2779306644 @default.
• W2114764690 hasConcept C2780613262 @default.
• W2114764690 hasConcept C511355011 @default.
• W2114764690 hasConcept C55493867 @default.
• W2114764690 hasConcept C71924100 @default.
• W2114764690 hasConcept C86803240 @default.
• W2114764690 hasConcept C95444343 @default.
• W2114764690 hasConceptScore W2114764690C104317684 @default.
• W2114764690 hasConceptScore W2114764690C126322002 @default.

• next