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• W2114767579 abstract "Thymidine phosphorylase (EC 2.4.2.4) catalyses the reversible phosphorolysis of pyrimidine 2′-deoxynucleosides, forming 2-deoxyribose-1-phosphate and pyrimidine. 5-Chloro-6-(2-imino-pyrrolidin-1-yl)methyl-uracil hydrochloride (TPI, 1) and its 5-bromo analogue (2), 6-(2-amino-imidazol-1-yl)methyl-5-bromo-uracil (3) and its 5-chloro analogue (4) act as tight-binding stoichiometric inhibitors of recombinant E. coli thymidine phosphorylase, and thus can be used as the first active-site titrants for it using either thymidine or 5-nitro-2′-deoxyuridine as substrate." @default.
• W2114767579 created "2016-06-24" @default.
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• W2114767579 date "2006-01-01" @default.
• W2114767579 modified "2023-10-11" @default.
• W2114767579 title "Thymidine phosphorylase from<i>Escherichia coli</i>: Tight-binding inhibitors as enzyme active-site titrants" @default.
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• W2114767579 doi "https://doi.org/10.1080/14756360500424010" @default.
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