FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114767865> ?p ?o ?g. }

• W2114767865 endingPage "764" @default.
• W2114767865 startingPage "753" @default.
• W2114767865 abstract "Macrophages are involved in many aspects of development, host defense, pathology, and homeostasis. Their normal differentiation, proliferation, and survival are controlled by CSF-1 via the activation of the CSF1R. A recently discovered cytokine, IL-34, was shown to bind the same receptor in humans. Chicken is a widely used model organism in developmental biology, but the factors that control avian myelopoiesis have not been identified previously. The CSF-1, IL-34, and CSF1R genes in chicken and zebra finch were identified from respective genomic/cDNA sequence resources. Comparative analysis of the avian CSF1R loci revealed likely orthologs of mammalian macrophage-specific promoters and enhancers, and the CSF1R gene is expressed in the developing chick embryo in a pattern consistent with macrophage-specific expression. Chicken CSF-1 and IL-34 were expressed in HEK293 cells and shown to elicit macrophage growth from chicken BM cells in culture. Comparative sequence and co-evolution analysis across all vertebrates suggests that the two ligands interact with distinct regions of the CSF1R. These studies demonstrate that there are two separate ligands for a functional CSF1R across all vertebrates." @default.
• W2114767865 created "2016-06-24" @default.
• W2114767865 creator A5011281193 @default.
• W2114767865 creator A5018058307 @default.
• W2114767865 creator A5023240519 @default.
• W2114767865 creator A5026642450 @default.
• W2114767865 creator A5040440615 @default.
• W2114767865 creator A5068995679 @default.
• W2114767865 creator A5079549226 @default.
• W2114767865 creator A5086500057 @default.
• W2114767865 date "2010-01-05" @default.
• W2114767865 modified "2023-09-27" @default.
• W2114767865 title "Pivotal Advance: Avian colony-stimulating factor 1 (<i>CSF-1</i>), interleukin-34 (<i>IL-34</i>), and <i>CSF-1</i> receptor genes and gene products" @default.
• W2114767865 cites W1551174843 @default.
• W2114767865 cites W1600203168 @default.
• W2114767865 cites W1814670478 @default.
• W2114767865 cites W1869320174 @default.
• W2114767865 cites W188699256 @default.
• W2114767865 cites W1967014060 @default.
• W2114767865 cites W1970062316 @default.
• W2114767865 cites W1977632246 @default.
• W2114767865 cites W1987057361 @default.
• W2114767865 cites W1993000387 @default.
• W2114767865 cites W1993733425 @default.
• W2114767865 cites W1998779768 @default.
• W2114767865 cites W1999916640 @default.
• W2114767865 cites W2001633946 @default.
• W2114767865 cites W2011549360 @default.
• W2114767865 cites W2012555257 @default.
• W2114767865 cites W2012775486 @default.
• W2114767865 cites W2018616287 @default.
• W2114767865 cites W2023795536 @default.
• W2114767865 cites W2024725966 @default.
• W2114767865 cites W2028377505 @default.
• W2114767865 cites W2031603575 @default.
• W2114767865 cites W2033784078 @default.
• W2114767865 cites W2035220839 @default.
• W2114767865 cites W2040142587 @default.
• W2114767865 cites W2049527237 @default.
• W2114767865 cites W2049696159 @default.
• W2114767865 cites W2054154416 @default.
• W2114767865 cites W2059368294 @default.
• W2114767865 cites W2059382129 @default.
• W2114767865 cites W2061798774 @default.
• W2114767865 cites W2065036402 @default.
• W2114767865 cites W2067420339 @default.
• W2114767865 cites W2070280444 @default.
• W2114767865 cites W2081567961 @default.
• W2114767865 cites W2086026340 @default.
• W2114767865 cites W2089270469 @default.
• W2114767865 cites W2090515509 @default.
• W2114767865 cites W2091770942 @default.
• W2114767865 cites W2095312814 @default.
• W2114767865 cites W2096843631 @default.
• W2114767865 cites W2099521287 @default.
• W2114767865 cites W2105156168 @default.
• W2114767865 cites W2106882534 @default.
• W2114767865 cites W2108486693 @default.
• W2114767865 cites W2110335151 @default.
• W2114767865 cites W2115520393 @default.
• W2114767865 cites W2120661271 @default.
• W2114767865 cites W2121867016 @default.
• W2114767865 cites W2130755020 @default.
• W2114767865 cites W2135735932 @default.
• W2114767865 cites W2136930121 @default.
• W2114767865 cites W2137184377 @default.
• W2114767865 cites W2138503227 @default.
• W2114767865 cites W2139967432 @default.
• W2114767865 cites W2143210482 @default.
• W2114767865 cites W2146955171 @default.
• W2114767865 cites W2149480059 @default.
• W2114767865 cites W2153187042 @default.
• W2114767865 cites W2155051670 @default.
• W2114767865 cites W2155644156 @default.
• W2114767865 cites W2157177142 @default.
• W2114767865 cites W2158539318 @default.
• W2114767865 cites W2159675211 @default.
• W2114767865 cites W2160803577 @default.
• W2114767865 cites W2417697141 @default.
• W2114767865 cites W3212157965 @default.
• W2114767865 cites W41981565 @default.
• W2114767865 doi "https://doi.org/10.1189/jlb.0909624" @default.
• W2114767865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20051473" @default.
• W2114767865 hasPublicationYear "2010" @default.
• W2114767865 type Work @default.
• W2114767865 sameAs 2114767865 @default.
• W2114767865 citedByCount "153" @default.
• W2114767865 countsByYear W21147678652012 @default.
• W2114767865 countsByYear W21147678652013 @default.
• W2114767865 countsByYear W21147678652014 @default.
• W2114767865 countsByYear W21147678652015 @default.
• W2114767865 countsByYear W21147678652016 @default.
• W2114767865 countsByYear W21147678652017 @default.
• W2114767865 countsByYear W21147678652018 @default.
• W2114767865 countsByYear W21147678652019 @default.
• W2114767865 countsByYear W21147678652020 @default.
• W2114767865 countsByYear W21147678652021 @default.
• W2114767865 countsByYear W21147678652022 @default.

• next