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- W2114769494 abstract "The importance of p53-function for the sensitivity to paclitaxel with and without hyperthermia (HT) was studied in an isogenic cell line system. The inactivation of p53 decreased sensitivity to paclitaxel (1.1-2.5-fold), which correlated with a lower induction of apoptosis. The magnitude of the G2/M arrest after treatment with paclitaxel was similar in all cell lines. The cytotoxicity of paclitaxel was not enhanced by HT in either wild-type p53 or p53-inactivated cells. In conclusion, cellular sensitivity to paclitaxel depends on p53-function by its ability to induce apoptosis. Irrespective of the p53-function HT was not able to enhance the sensitivity to paclitaxel." @default.
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- W2114769494 date "2000-04-01" @default.
- W2114769494 modified "2023-09-22" @default.
- W2114769494 title "The effect of p53-function on the sensitivity to paclitaxel with or without hyperthermia in human colorectal carcinoma cells." @default.
- W2114769494 doi "https://doi.org/10.3892/ijo.16.4.739" @default.
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