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- W2114780647 abstract "The disposition of fluid given by i.v. infusion can be studied by fitting one-volume and two-volume kinetic models to the fractioned dilution of blood haemoglobin and serum albumin concentrations over time. However, the two-volume model is sometimes associated with a high standard error in estimating the size of the secondary (peripheral) body fluid space, V2. To examine if a fixed elimination rate constant (kr) determined by urinary excretion can be used to make the model more stable, we infused Ringer's acetate 25 ml kg-1 over 30 min in 15 male volunteers (mean age 35 yr). A fixed kr increased the total residual error when curve-fitting was applied according to the one-volume model. The two-volume model was improved when there was a strong within-patient covariance between kr and V2 (r2 < or = -0.98). The size of V2 was 10 litre when the fixed and model-generated values of kr agreed fully." @default.
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- W2114780647 date "1998-02-01" @default.
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- W2114780647 title "Urinary excretion as an input variable in volume kinetic analysis of Ringer's solution" @default.
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- W2114780647 doi "https://doi.org/10.1093/bja/80.2.183" @default.
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