FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114783584> ?p ?o ?g. }

• W2114783584 endingPage "23" @default.
• W2114783584 startingPage "1" @default.
• W2114783584 abstract "Although systemic radionuclide therapy (SRT) is effective as a palliative therapy in patients with metastatic cancer, there has been limited success in expanding patterns of utilization and in bringing novel systemic radiotherapeutic agents to routine clinical use. Although there are many factors that contribute to this situation, we hypothesize that a better understanding of the radiobiology and mechanism of action of SRT will facilitate the development of future compounds and the future designs of prospective clinical trials. If these trials can be rationalized to the biological basis of the therapy, it is likely that the long-term outcome would be enhanced therapeutic efficacy. In this review, we provide perspectives of the current state of low-dose-rate (LDR) radiation research and offer linkages where appropriate with current clinical knowledge. These include the recently described phenomena of low-dose hyper-radiosensitivity-increased radioresistance (LDH-IRR), adaptive responses, and biological bystander effects. Each of these areas require a major reconsideration of existing models for radiation action and an understanding of how this knowledge will integrate into the evolution of clinical SRT practice. Validation of a role in vivo for both LDH-IRR and biological bystander effects in SRT would greatly impact the way we would assess therapeutic response to SRT, the design of clinical trials of novel SRT radiopharmaceuticals, and risk estimates for both therapeutic and diagnostic radiopharmaceuticals. We believe that the current state of research in LDR effects offers a major opportunity to the nuclear medicine community to address the basic science of clinical SRT practice, to use this new knowledge to expand the use and roles of SRT, and to facilitate the introduction of new therapeutic radiopharmaceuticals." @default.
• W2114783584 created "2016-06-24" @default.
• W2114783584 creator A5051563559 @default.
• W2114783584 creator A5077958367 @default.
• W2114783584 date "2007-02-01" @default.
• W2114783584 modified "2023-09-26" @default.
• W2114783584 title "Radiobiology of Systemic Radiation Therapy" @default.
• W2114783584 cites W1568146676 @default.
• W2114783584 cites W1582679620 @default.
• W2114783584 cites W1641920546 @default.
• W2114783584 cites W1874688327 @default.
• W2114783584 cites W1975447309 @default.
• W2114783584 cites W1975664090 @default.
• W2114783584 cites W1977596479 @default.
• W2114783584 cites W1978275013 @default.
• W2114783584 cites W1981292909 @default.
• W2114783584 cites W1983514189 @default.
• W2114783584 cites W1985061998 @default.
• W2114783584 cites W1987845412 @default.
• W2114783584 cites W1989897071 @default.
• W2114783584 cites W1990143951 @default.
• W2114783584 cites W1990693536 @default.
• W2114783584 cites W1992675784 @default.
• W2114783584 cites W1996253290 @default.
• W2114783584 cites W1999134519 @default.
• W2114783584 cites W2001823769 @default.
• W2114783584 cites W2007861801 @default.
• W2114783584 cites W2009836431 @default.
• W2114783584 cites W2010027532 @default.
• W2114783584 cites W2010429822 @default.
• W2114783584 cites W2010956382 @default.
• W2114783584 cites W2010997285 @default.
• W2114783584 cites W2012393865 @default.
• W2114783584 cites W2013944496 @default.
• W2114783584 cites W2015181794 @default.
• W2114783584 cites W2016599680 @default.
• W2114783584 cites W2019219567 @default.
• W2114783584 cites W2019242610 @default.
• W2114783584 cites W2022206463 @default.
• W2114783584 cites W2022811243 @default.
• W2114783584 cites W2026377273 @default.
• W2114783584 cites W2028361915 @default.
• W2114783584 cites W2029903973 @default.
• W2114783584 cites W2036270526 @default.
• W2114783584 cites W2040136020 @default.
• W2114783584 cites W2043303586 @default.
• W2114783584 cites W2045164156 @default.
• W2114783584 cites W2045970953 @default.
• W2114783584 cites W2045991184 @default.
• W2114783584 cites W2046008851 @default.
• W2114783584 cites W2047258328 @default.
• W2114783584 cites W2047551799 @default.
• W2114783584 cites W2050480919 @default.
• W2114783584 cites W2051862120 @default.
• W2114783584 cites W2055038372 @default.
• W2114783584 cites W2056106885 @default.
• W2114783584 cites W2056714821 @default.
• W2114783584 cites W2057383698 @default.
• W2114783584 cites W2059921850 @default.
• W2114783584 cites W2062107951 @default.
• W2114783584 cites W2066501151 @default.
• W2114783584 cites W2068755461 @default.
• W2114783584 cites W2068775401 @default.
• W2114783584 cites W2070408871 @default.
• W2114783584 cites W2070701799 @default.
• W2114783584 cites W2072153851 @default.
• W2114783584 cites W2073584487 @default.
• W2114783584 cites W2073910928 @default.
• W2114783584 cites W2075497030 @default.
• W2114783584 cites W2075889895 @default.
• W2114783584 cites W2077066643 @default.
• W2114783584 cites W2080434562 @default.
• W2114783584 cites W2084188360 @default.
• W2114783584 cites W2084491525 @default.
• W2114783584 cites W2088792252 @default.
• W2114783584 cites W2089487644 @default.
• W2114783584 cites W2089804431 @default.
• W2114783584 cites W2091493364 @default.
• W2114783584 cites W2096200284 @default.
• W2114783584 cites W2096609221 @default.
• W2114783584 cites W2096782300 @default.
• W2114783584 cites W2097907715 @default.
• W2114783584 cites W2099888675 @default.
• W2114783584 cites W2103227635 @default.
• W2114783584 cites W2110438701 @default.
• W2114783584 cites W2111382211 @default.
• W2114783584 cites W2115485662 @default.
• W2114783584 cites W2115532724 @default.
• W2114783584 cites W2117352925 @default.
• W2114783584 cites W2118171008 @default.
• W2114783584 cites W2119860700 @default.
• W2114783584 cites W2119999819 @default.
• W2114783584 cites W2120683054 @default.
• W2114783584 cites W2122162888 @default.
• W2114783584 cites W2123679826 @default.
• W2114783584 cites W2125570867 @default.
• W2114783584 cites W2128530877 @default.
• W2114783584 cites W212927979 @default.

• next