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• W2114800955 abstract "Primary anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies from C57BL/6 mice were idiotypically defined by a rabbit anti-idiotypic antiserum. The idiotypic marker detected by this antiserum (the NPb idiotype) requires for its expression a specific heavy (H) chain-lambda (Λ) light (L) chain combination as shown in chain reassociation experiments. The idiotypic binding reaction is inhibitable by hapten. BALB/c and CBA mice also produce large amounts of Λ-bearing anti-NP antibodies, but these do not express the NPb idiotype as defined by the rabbit antiserum. Since the NPb idiotype could be reconstituted by reassociating C57 BL/6 anti-NP antibody H chains with either HOPC 1, or BALB/c or CBA anti-NP antibody Λ chains, the absence of the NPb idiotype in BALB/c and CBA antibodies implies that these animals express different sets of H chain variable (V) regions in the anti-NP response. SJL mice, in contrast to other mouse strains with the Ig-1b allotype, express only traces of NPb idiotype in their anti-NP antibodies, the L chains of which are almost exclusively of the χ type. Knowing that SJL mice possess a regulatory gene responsible for the low level of Λ (Λ10) chains in their immunoglobulins, we have analyzed the progeny of (SJL × BALB/C)F1, (SJL × BALB/C)F1 × BALB/C and (SJL × BALB/C)F1 × SJL for the expression of Λ-bearing anti-NP antibodies and NPb idiotype. In accord with previous work (SJL × BALB/c)F1 mice produced substantial amounts of anti-NP antibodies with the NPb idiotype. Backcross of these mice to BALB/c revealed linkage of the NPb idiotype to the Ig-1b allotype, in agreement with previous data. Backcross of the F1 animals to SJL demonstrated control of the NPb idiotype by the gene regulating Λ chain expression in serum immunoglobulin. Chain reassociation experiments showed that in SJL mice, the regulation against Λ chain expression prevents the selection in the anti-NP response of those H chains that together with Λ chains constitute the NPb idiotype. Apparently, these H chains are unable to contribute to a binding site with specificity for the NP hapten when combined with χ chains." @default.
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• W2114800955 date "1979-04-01" @default.
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• W2114800955 title "The effect of light chain gene expression on the inheritance of an idiotype associated with primary anti-(4-hydroxy-3-nitrophenyl)acetyl(NP) antibodies" @default.
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• W2114800955 doi "https://doi.org/10.1002/eji.1830090414" @default.
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