FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114806898> ?p ?o ?g. }

• W2114806898 endingPage "211" @default.
• W2114806898 startingPage "206" @default.
• W2114806898 abstract "Inflammation, a process that involves neutrophils, lymphocytes, and monocytes, contributes to cerebral ischemic injury. Blockade of neutrophil adhesion to endothelium improves outcome after experimental stroke. In this study we sought to assess the contribution of lymphocytes and monocytes to ischemic brain injury.Male Lewis rats underwent 3 hours of middle cerebral artery occlusion followed by 45 hours of reperfusion. Two hours after the onset of ischemia, one group of animals received an intraperitoneal injection of antibodies to the alpha(4) integrin (n=16); another group was injected with an isotype control antibody (n=11). Neurological examination, body temperature, and body weight were assessed at different time points after stroke. Animals were killed 48 hours after the onset of ischemia for determination of infarct volume and leukocyte counts.There were no significant differences in body temperature or weight at any time. Neurological scores (deficits) were significantly less in animals treated with anti-alpha(4) antibodies at 24 (2.0+/-1.2 versus 3. 0+/-0.4; P:=0.006) and 48 (2.0+/-1.2 versus 3.0+/-0.8; P:=0.011) hours after ischemia. Peripheral blood leukocyte counts were significantly higher in anti-alpha(4)-treated animals (6.8+/-2.2 x 10(9) versus 2.9+/-1.9 x 10(9); P:=0.001) and revealed a lymphocyte/monocyte predominance (86.0+/-16.2% versus 71.0+/-15.6%; P:=0.008). Infarct volume was significantly less in animals treated with antibodies to alpha(4) (120.1+/-51.21 versus 173.7+/-42.29 mm(3); P:=0.012).These data support a role for lymphocytes and monocytes in cerebral ischemic injury and show that blockade of alpha(4), even when instituted after the onset of ischemia, can improve neurological outcome and decrease infarct volume." @default.
• W2114806898 created "2016-06-24" @default.
• W2114806898 creator A5017463095 @default.
• W2114806898 creator A5031353463 @default.
• W2114806898 creator A5050370903 @default.
• W2114806898 creator A5082034991 @default.
• W2114806898 creator A5082745011 @default.
• W2114806898 date "2001-01-01" @default.
• W2114806898 modified "2023-10-18" @default.
• W2114806898 title "Antibody to the α4 Integrin Decreases Infarct Size in Transient Focal Cerebral Ischemia in Rats" @default.
• W2114806898 cites W1473358294 @default.
• W2114806898 cites W1489618651 @default.
• W2114806898 cites W1587796772 @default.
• W2114806898 cites W1618952314 @default.
• W2114806898 cites W1776104341 @default.
• W2114806898 cites W1946962848 @default.
• W2114806898 cites W1959529696 @default.
• W2114806898 cites W1966056375 @default.
• W2114806898 cites W1966800711 @default.
• W2114806898 cites W1968734559 @default.
• W2114806898 cites W1972408244 @default.
• W2114806898 cites W1988086690 @default.
• W2114806898 cites W1996751718 @default.
• W2114806898 cites W1998814509 @default.
• W2114806898 cites W2002427402 @default.
• W2114806898 cites W2022184416 @default.
• W2114806898 cites W2023396428 @default.
• W2114806898 cites W2025326202 @default.
• W2114806898 cites W2030492769 @default.
• W2114806898 cites W2032445159 @default.
• W2114806898 cites W2050483076 @default.
• W2114806898 cites W2054113452 @default.
• W2114806898 cites W2062221766 @default.
• W2114806898 cites W2062265210 @default.
• W2114806898 cites W2063094517 @default.
• W2114806898 cites W2069727032 @default.
• W2114806898 cites W2073839915 @default.
• W2114806898 cites W2076167504 @default.
• W2114806898 cites W2077944387 @default.
• W2114806898 cites W2078840769 @default.
• W2114806898 cites W2092830773 @default.
• W2114806898 cites W2093351410 @default.
• W2114806898 cites W2100070617 @default.
• W2114806898 cites W2108617074 @default.
• W2114806898 cites W2118724414 @default.
• W2114806898 cites W2119741323 @default.
• W2114806898 cites W2128509983 @default.
• W2114806898 cites W2154920085 @default.
• W2114806898 cites W2156076525 @default.
• W2114806898 cites W2402226646 @default.
• W2114806898 doi "https://doi.org/10.1161/01.str.32.1.206" @default.
• W2114806898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11136938" @default.
• W2114806898 hasPublicationYear "2001" @default.
• W2114806898 type Work @default.
• W2114806898 sameAs 2114806898 @default.
• W2114806898 citedByCount "144" @default.
• W2114806898 countsByYear W21148068982012 @default.
• W2114806898 countsByYear W21148068982013 @default.
• W2114806898 countsByYear W21148068982014 @default.
• W2114806898 countsByYear W21148068982015 @default.
• W2114806898 countsByYear W21148068982016 @default.
• W2114806898 countsByYear W21148068982017 @default.
• W2114806898 countsByYear W21148068982018 @default.
• W2114806898 countsByYear W21148068982019 @default.
• W2114806898 countsByYear W21148068982020 @default.
• W2114806898 countsByYear W21148068982021 @default.
• W2114806898 countsByYear W21148068982022 @default.
• W2114806898 countsByYear W21148068982023 @default.
• W2114806898 crossrefType "journal-article" @default.
• W2114806898 hasAuthorship W2114806898A5017463095 @default.
• W2114806898 hasAuthorship W2114806898A5031353463 @default.
• W2114806898 hasAuthorship W2114806898A5050370903 @default.
• W2114806898 hasAuthorship W2114806898A5082034991 @default.
• W2114806898 hasAuthorship W2114806898A5082745011 @default.
• W2114806898 hasBestOaLocation W21148068981 @default.
• W2114806898 hasConcept C126322002 @default.
• W2114806898 hasConcept C127413603 @default.
• W2114806898 hasConcept C134018914 @default.
• W2114806898 hasConcept C142724271 @default.
• W2114806898 hasConcept C159654299 @default.
• W2114806898 hasConcept C203014093 @default.
• W2114806898 hasConcept C2775841333 @default.
• W2114806898 hasConcept C2776914184 @default.
• W2114806898 hasConcept C2777761686 @default.
• W2114806898 hasConcept C2777798775 @default.
• W2114806898 hasConcept C2780645631 @default.
• W2114806898 hasConcept C42219234 @default.
• W2114806898 hasConcept C500558357 @default.
• W2114806898 hasConcept C541997718 @default.
• W2114806898 hasConcept C71924100 @default.
• W2114806898 hasConcept C78519656 @default.
• W2114806898 hasConceptScore W2114806898C126322002 @default.
• W2114806898 hasConceptScore W2114806898C127413603 @default.
• W2114806898 hasConceptScore W2114806898C134018914 @default.
• W2114806898 hasConceptScore W2114806898C142724271 @default.
• W2114806898 hasConceptScore W2114806898C159654299 @default.
• W2114806898 hasConceptScore W2114806898C203014093 @default.
• W2114806898 hasConceptScore W2114806898C2775841333 @default.

• next