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• W2114809916 abstract "Cadmium (Cd) is a ubiquitous environmental pollutant of increasing worldwide concern. It is thought to be of greater concern to rapidly industrializing developing countries because of the increasing pace of industrial activities in these countries with increasing consumption and release into the environment. Traditionally, health concerns in exposed human populations have revolved around the association of Cd with bone disease, emphysema and possibly hypertension. Accumulating evidence suggest that Cd is involved in the disruption of many genomic processes, the mechanisms of which are being gradually understood. Changes in DNA methylation may be induced by cadmium leading to epigenetic alterations. Additionally, though Cd is not thought to induce Reactive Oxygen Species (ROS) directly because it is not capable of accepting or donating electrons under physiological conditions, 8-hydroxy deoxyguanosine (8-OHdG) (a marker of oxidative stress to DNA and a risk factor for cancer among others) has been shown to be elevated in the DNA of testes from rats treated with cadmium chloride, at least in part because Cd inhibits DNA repair mechanisms. Cadmium is also a metabolic antagonist to Zinc (Zn), an important micronutrient involved in numerous molecular activities. This antagonism alters the physiological stoichiometric relationship between Cd and Zn leading to high Cd/Zn ratio, one consequence of which is high error rate and lack of efficient DNA repair systems leading to high mutation and genome instability culminating in many carcinogenic states, particularly prostate carcinogenesis. Cadmium has also been shown to replace Zn in the tumor suppressor protein, p53 thereby impairing p53’s DNA binding activity and associated repair processes. The expression of the p53 protein is significantly depressed by cadmium. Although the rising level of Cd in the environment is widely acknowledged, the occult threat it poses to genome stability largely through inhibition normal DNA damage repair, oxidative stress, apoptosis and health is poorly recognized. This paper examines the involvement of Cd in the molecular pathways of human disease, providing insight for the prevention of genome instability and associated disease susceptibility particularly cancer across populations through micronutrient intervention, aiding upregulation of the antioxidant defense and DNA repair systems." @default.
• W2114809916 created "2016-06-24" @default.
• W2114809916 creator A5011347517 @default.
• W2114809916 date "2012-01-01" @default.
• W2114809916 modified "2023-10-14" @default.
• W2114809916 title "Rising Environmental Cadmium Levels in Developing Countries: Threat to Genome Stability and Health" @default.
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• W2114809916 cites W1605551606 @default.
• W2114809916 cites W1965734230 @default.
• W2114809916 cites W1966022964 @default.
• W2114809916 cites W1970658270 @default.
• W2114809916 cites W1974389934 @default.
• W2114809916 cites W1976334661 @default.
• W2114809916 cites W197752284 @default.
• W2114809916 cites W1977985536 @default.
• W2114809916 cites W1979132200 @default.
• W2114809916 cites W1985253635 @default.
• W2114809916 cites W1986487308 @default.
• W2114809916 cites W1986968026 @default.
• W2114809916 cites W1990847750 @default.
• W2114809916 cites W1991535520 @default.
• W2114809916 cites W1999497809 @default.
• W2114809916 cites W2000065525 @default.
• W2114809916 cites W2002257019 @default.
• W2114809916 cites W2002801265 @default.
• W2114809916 cites W2003115773 @default.
• W2114809916 cites W2013788352 @default.
• W2114809916 cites W2015253889 @default.
• W2114809916 cites W2017223556 @default.
• W2114809916 cites W2020913460 @default.
• W2114809916 cites W2029971548 @default.
• W2114809916 cites W2033285747 @default.
• W2114809916 cites W2033968745 @default.
• W2114809916 cites W2036366834 @default.
• W2114809916 cites W2036627122 @default.
• W2114809916 cites W2037299400 @default.
• W2114809916 cites W2040015732 @default.
• W2114809916 cites W2042830107 @default.
• W2114809916 cites W2043020476 @default.
• W2114809916 cites W2043033879 @default.
• W2114809916 cites W2044221156 @default.
• W2114809916 cites W2044424039 @default.
• W2114809916 cites W2045515144 @default.
• W2114809916 cites W2047104027 @default.
• W2114809916 cites W2049003915 @default.
• W2114809916 cites W2051612492 @default.
• W2114809916 cites W2052230594 @default.
• W2114809916 cites W2055290498 @default.
• W2114809916 cites W2057627076 @default.
• W2114809916 cites W2065611897 @default.
• W2114809916 cites W2066635729 @default.
• W2114809916 cites W2069503557 @default.
• W2114809916 cites W2073949474 @default.
• W2114809916 cites W2074227902 @default.
• W2114809916 cites W2077701145 @default.
• W2114809916 cites W2088353617 @default.
• W2114809916 cites W2091726202 @default.
• W2114809916 cites W2092669986 @default.
• W2114809916 cites W2103474203 @default.
• W2114809916 cites W2104048659 @default.
• W2114809916 cites W2107430951 @default.
• W2114809916 cites W2110486307 @default.
• W2114809916 cites W2114444804 @default.
• W2114809916 cites W2118682325 @default.
• W2114809916 cites W2130318636 @default.
• W2114809916 cites W2132175411 @default.
• W2114809916 cites W2147569445 @default.
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• W2114809916 cites W2157726749 @default.
• W2114809916 cites W2161688851 @default.
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• W2114809916 cites W2394536623 @default.
• W2114809916 cites W2418265942 @default.
• W2114809916 cites W2466992631 @default.
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• W2114809916 doi "https://doi.org/10.4172/2161-0525.1000140" @default.
• W2114809916 hasPublicationYear "2012" @default.
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