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• W2114821388 abstract "<i>Objective:</i> Leukocyte activation is thought to be responsible for the adverse effects and postoperative complications following cardiopulmonary bypass (CPB). A novel cell surface molecule, CD97, is a sensitive marker of leukocyte and primary lymphocyte activation. The present study aimed to determine the activation of different leukocyte subsets by comparing the expression of CD97 and adhesion molecules (CD11, CD18) in patients receiving coronary surgery with or without CPB. <i>Methods:</i> 30 patients were enrolled and scheduled for coronary bypass surgery under CPB (20 patients, group A) and with off-pump (OP) operation (10 patients, group B). Blood samples were taken before and during surgery, and over the following first week. <i>Results:</i> Here, we report an early decrease in CD97 expression of granulocytes (PMN) and monocytes (MC) followed by an intensive increase reaching the maximum on postoperative days 2 and 3 in patients operated with CPB. The rate of active CD97-positive lymphocytes showed a marked, gradual increase until postoperative day 3 and remained elevated up to day 7 after CPB. OP surgery resulted in moderate alteration in the presence of CD97 on PMN, MC and lymphocytes. The expression of adhesion molecules was similar to CD97 in all leukocyte subsets. <i>Conclusion:</i> The findings about CD97 expression suggest considerable leukocyte activation following coronary bypass with CPB compared to OP surgery. The collected data show that the lymphocytes are highly activated and involved in leukocyte sequestration after CPB. Moreover, the importance of CD97 in CPB-related inflammatory response can be stated." @default.
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• W2114821388 date "2005-01-01" @default.
• W2114821388 modified "2023-10-18" @default.
• W2114821388 title "Expression of CD97 and Adhesion Molecules on Circulating Leukocytes in Patients Undergoing Coronary Artery Bypass Surgery" @default.
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• W2114821388 doi "https://doi.org/10.1159/000089237" @default.
• W2114821388 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16374010" @default.
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