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• W2114834281 abstract "Abstract: The effect of some selective monoamine oxidase (MAO) inhibitors on aromatic L-amino acid decarboxylase (AADC) gene expression in PC12 cells has been examined. Irreversible MAO B inhibitors [(–)-deprenyl, pargyline, and MDL 72,974A] stimulated AADC gene expression, whereas a selective irreversible MAO A inhibitor (clorgyline) and a reversible MAO B inhibitor (Ro 19-6327) had no effect. Because there is no apparent MAO B activity in PC12 cells, it is postulated that there is a novel site of action for these MAO B inhibitors and that the pharmacological profile of this site matches that of neuroprotective MAO B inhibitors. Finally, it is suggested that the stimulation of AADC gene expression may be relevant to the antiparkinsonian effects of MAO B inhibitors." @default.
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• W2114834281 date "2006-10-05" @default.
• W2114834281 modified "2023-09-24" @default.
• W2114834281 title "Specific Irreversible Monoamine Oxidase B Inhibitors Stimulate Gene Expression of Aromatic L-Amino Acid Decarboxylase in PC12 Cells" @default.
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• W2114834281 doi "https://doi.org/10.1111/j.1471-4159.1992.tb10127.x" @default.
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