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- W2114834794 abstract "Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the pericellular space. To address the role of PDGF-B retention in vivo, we deleted the retention motif by gene targeting in mice. This resulted in defective investment of pericytes in the microvessel wall and delayed formation of the renal glomerulus mesangium. Long-term effects of lack of PDGF-B retention included severe retinal deterioration, glomerulosclerosis, and proteinuria. We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice." @default.
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- W2114834794 date "2003-08-01" @default.
- W2114834794 modified "2023-10-18" @default.
- W2114834794 title "Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall" @default.
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- W2114834794 doi "https://doi.org/10.1101/gad.266803" @default.
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