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- W2114857498 abstract "In recent years, discovery of ketamine's fast and powerful antidepressant effects for treatment-resistant depression (TRD) has led to rethinking of the pathophysiology of depression. Numerous studies in humans and animals have focused on mechanisms of action underlying this effect, producing a number of explanatory pathways.The aim of this article is to summarize the various hypotheses underlying rapid antidepressant action of ketamine and therefore to better understand the mechanisms underlying depression and antidepressant action.Ketamine unique antidepressant properties have led to many studies on its neurobiological grounds. Intracellular signaling pathways such as mTOR, GSK3 or eEF2 seem to play a key role and are associated with an increased synaptic plasticity. Other hypotheses are discussed such as ketamine effects on neuro-inflammation, the role of anterior cingulate cortex in brain changes induced by ketamine, and the potential benefits of analgesic properties of ketamine in depressive disorders.Our review highlights the potential role of the glutamatergic system in the pathophysiology and treatment of mood disorders. Understanding which pathways underlie the fast antidepressant effect of ketamine paves the way for the development of new antidepressants." @default.
- W2114857498 created "2016-06-24" @default.
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- W2114857498 date "2014-02-01" @default.
- W2114857498 modified "2023-09-24" @default.
- W2114857498 title "Effet antidépresseur de la kétamine : revue de la littérature sur les mécanismes d’action de la kétamine" @default.
- W2114857498 cites W1628671034 @default.
- W2114857498 cites W1847305855 @default.
- W2114857498 cites W1914381346 @default.
- W2114857498 cites W1964466640 @default.
- W2114857498 cites W1969852349 @default.
- W2114857498 cites W1970328639 @default.
- W2114857498 cites W1976392245 @default.
- W2114857498 cites W1977465442 @default.
- W2114857498 cites W1981097208 @default.
- W2114857498 cites W1988059170 @default.
- W2114857498 cites W1988836643 @default.
- W2114857498 cites W1994455271 @default.
- W2114857498 cites W1996311338 @default.
- W2114857498 cites W1998232402 @default.
- W2114857498 cites W1998878650 @default.
- W2114857498 cites W2000606058 @default.
- W2114857498 cites W2000895251 @default.
- W2114857498 cites W2002111967 @default.
- W2114857498 cites W2013262472 @default.
- W2114857498 cites W2017149290 @default.
- W2114857498 cites W2022279290 @default.
- W2114857498 cites W2022994360 @default.
- W2114857498 cites W2023081218 @default.
- W2114857498 cites W2026228402 @default.
- W2114857498 cites W2028884770 @default.
- W2114857498 cites W2031023279 @default.
- W2114857498 cites W2031336376 @default.
- W2114857498 cites W2031645017 @default.
- W2114857498 cites W2032739515 @default.
- W2114857498 cites W2036814814 @default.
- W2114857498 cites W2044325416 @default.
- W2114857498 cites W2049022403 @default.
- W2114857498 cites W2051187163 @default.
- W2114857498 cites W2061711185 @default.
- W2114857498 cites W2065940552 @default.
- W2114857498 cites W2067088153 @default.
- W2114857498 cites W2067166581 @default.
- W2114857498 cites W2074013156 @default.
- W2114857498 cites W2076406171 @default.
- W2114857498 cites W2076682630 @default.
- W2114857498 cites W2077532061 @default.
- W2114857498 cites W2083204774 @default.
- W2114857498 cites W2086760389 @default.
- W2114857498 cites W2089351762 @default.
- W2114857498 cites W2092802479 @default.
- W2114857498 cites W2094166526 @default.
- W2114857498 cites W2094348922 @default.
- W2114857498 cites W2094920961 @default.
- W2114857498 cites W2102666165 @default.
- W2114857498 cites W2103255996 @default.
- W2114857498 cites W2109334244 @default.
- W2114857498 cites W2110247921 @default.
- W2114857498 cites W2110921107 @default.
- W2114857498 cites W2110960534 @default.
- W2114857498 cites W2111028594 @default.
- W2114857498 cites W2113458499 @default.
- W2114857498 cites W2121117021 @default.
- W2114857498 cites W2123160535 @default.
- W2114857498 cites W2123274136 @default.
- W2114857498 cites W2136250464 @default.
- W2114857498 cites W2138494591 @default.
- W2114857498 cites W2138496385 @default.
- W2114857498 cites W2138517367 @default.
- W2114857498 cites W2146758523 @default.
- W2114857498 cites W2148880706 @default.
- W2114857498 cites W2148942933 @default.
- W2114857498 cites W2152644978 @default.
- W2114857498 cites W2159568556 @default.
- W2114857498 cites W2160383565 @default.
- W2114857498 cites W2163224933 @default.
- W2114857498 cites W2165902008 @default.
- W2114857498 cites W2167565363 @default.
- W2114857498 cites W2170862369 @default.
- W2114857498 cites W2324282515 @default.
- W2114857498 cites W2347176569 @default.
- W2114857498 cites W2588331115 @default.
- W2114857498 cites W2777987555 @default.
- W2114857498 cites W2803277739 @default.
- W2114857498 cites W2958079849 @default.
- W2114857498 cites W2972479659 @default.
- W2114857498 cites W85163216 @default.
- W2114857498 doi "https://doi.org/10.1016/j.encep.2013.09.002" @default.
- W2114857498 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24434007" @default.
- W2114857498 hasPublicationYear "2014" @default.
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