Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114863910> ?p ?o ?g. }
- W2114863910 abstract "CSCs are responsible for the high rate of recurrence and chemoresistance of different types of cancer. The current antineoplastic agents able to inhibit bulk replicating cancer cells and radiation treatment are not efficacious toward CSCs since this subpopulation has several intrinsic mechanisms of resistance. Among these mechanisms, the expression of ATP-Binding Cassette (ABC) transporters family and the activation of different signaling pathways (such as Wnt/β-catenin signaling, Hedgehog, Notch, Akt/PKB) are reported. Therefore, considering ABC transporters expression on CSCs membranes, compounds able to modulate MDR could induce cytotoxicity in these cells disclosing an exciting and alternative strategy for targeting CSCs in tumor therapy. The next challenge in the cure of cancer relapse may be a multimodal strategy, an approach where specific CSCs targeting drugs exert simultaneously the ability to circumvent tumor drug resistance (ABC transporters modulation) and cytotoxic activity toward CSCs and the corresponding differentiated tumor cells. The efficacy of suggested multimodal strategy could be probed by using several scaffolds active toward MDR pumps on CSCs isolated by tumor specimens." @default.
- W2114863910 created "2016-06-24" @default.
- W2114863910 creator A5005991818 @default.
- W2114863910 creator A5014092043 @default.
- W2114863910 creator A5021058541 @default.
- W2114863910 creator A5029727582 @default.
- W2114863910 creator A5066373482 @default.
- W2114863910 creator A5089166509 @default.
- W2114863910 date "2014-07-10" @default.
- W2114863910 modified "2023-10-18" @default.
- W2114863910 title "ABC transporters in CSCs membranes as a novel target for treating tumor relapse" @default.
- W2114863910 cites W1499177907 @default.
- W2114863910 cites W1511999879 @default.
- W2114863910 cites W1737173245 @default.
- W2114863910 cites W1739249602 @default.
- W2114863910 cites W1961560083 @default.
- W2114863910 cites W1964427001 @default.
- W2114863910 cites W1964632037 @default.
- W2114863910 cites W1968192372 @default.
- W2114863910 cites W1970572671 @default.
- W2114863910 cites W1970972818 @default.
- W2114863910 cites W1973354681 @default.
- W2114863910 cites W1974089576 @default.
- W2114863910 cites W1977075884 @default.
- W2114863910 cites W1977342376 @default.
- W2114863910 cites W1979421565 @default.
- W2114863910 cites W1979585278 @default.
- W2114863910 cites W1980684292 @default.
- W2114863910 cites W1983974579 @default.
- W2114863910 cites W1985796734 @default.
- W2114863910 cites W1986053522 @default.
- W2114863910 cites W1988943434 @default.
- W2114863910 cites W1990046017 @default.
- W2114863910 cites W1993766071 @default.
- W2114863910 cites W1994131697 @default.
- W2114863910 cites W1994504180 @default.
- W2114863910 cites W1996984755 @default.
- W2114863910 cites W1997280228 @default.
- W2114863910 cites W1998708832 @default.
- W2114863910 cites W1999917099 @default.
- W2114863910 cites W2000836100 @default.
- W2114863910 cites W2000858319 @default.
- W2114863910 cites W2001266427 @default.
- W2114863910 cites W2001438931 @default.
- W2114863910 cites W2002601186 @default.
- W2114863910 cites W2004419844 @default.
- W2114863910 cites W2006419043 @default.
- W2114863910 cites W2006893320 @default.
- W2114863910 cites W2007369931 @default.
- W2114863910 cites W2008293422 @default.
- W2114863910 cites W2009094422 @default.
- W2114863910 cites W2009124637 @default.
- W2114863910 cites W2010317454 @default.
- W2114863910 cites W2011132846 @default.
- W2114863910 cites W2012087132 @default.
- W2114863910 cites W2012619882 @default.
- W2114863910 cites W2014406829 @default.
- W2114863910 cites W2015303096 @default.
- W2114863910 cites W2018301172 @default.
- W2114863910 cites W2018360235 @default.
- W2114863910 cites W2019007505 @default.
- W2114863910 cites W2019264784 @default.
- W2114863910 cites W2019768326 @default.
- W2114863910 cites W2019977318 @default.
- W2114863910 cites W2020131167 @default.
- W2114863910 cites W2020153682 @default.
- W2114863910 cites W2020662688 @default.
- W2114863910 cites W2022451432 @default.
- W2114863910 cites W2023427658 @default.
- W2114863910 cites W2024520801 @default.
- W2114863910 cites W2024965589 @default.
- W2114863910 cites W2026522253 @default.
- W2114863910 cites W2026862874 @default.
- W2114863910 cites W2027102742 @default.
- W2114863910 cites W2028298372 @default.
- W2114863910 cites W2029231546 @default.
- W2114863910 cites W2029497007 @default.
- W2114863910 cites W2032345011 @default.
- W2114863910 cites W2035023838 @default.
- W2114863910 cites W2035604949 @default.
- W2114863910 cites W2037353448 @default.
- W2114863910 cites W2039789255 @default.
- W2114863910 cites W2040942754 @default.
- W2114863910 cites W2042619042 @default.
- W2114863910 cites W2045000546 @default.
- W2114863910 cites W2046851174 @default.
- W2114863910 cites W2049820663 @default.
- W2114863910 cites W2051011734 @default.
- W2114863910 cites W2052837067 @default.
- W2114863910 cites W2052902650 @default.
- W2114863910 cites W2053848658 @default.
- W2114863910 cites W2054741841 @default.
- W2114863910 cites W2057257265 @default.
- W2114863910 cites W2057995674 @default.
- W2114863910 cites W2059281433 @default.
- W2114863910 cites W2061738087 @default.
- W2114863910 cites W2062069198 @default.
- W2114863910 cites W2064044156 @default.
- W2114863910 cites W2065171137 @default.
- W2114863910 cites W2066503079 @default.