Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114867586> ?p ?o ?g. }
- W2114867586 endingPage "4357" @default.
- W2114867586 startingPage "4351" @default.
- W2114867586 abstract "Despite the impressive protection of B cell-deficient (muMT(-/-)) nonobese diabetic (NOD) mice from spontaneous diabetes, existence of mild pancreatic islet inflammation in these mice indicates that initial autoimmune targeting of beta cells has occurred. Furthermore, muMT(-/-) NOD mice are shown to harbor a latent repertoire of diabetogenic T cells, as evidenced by their susceptibility to cyclophosphamide-induced diabetes. The quiescence of this pool of islet-reactive T cells may be a consequence of impaired activation of T lymphocytes in B cell-deficient NOD mice. In this regard, in vitro anti-CD3-mediated stimulation demonstrates impaired activation of lymph node CD4 T cells in muMT(-/-) NOD mice as compared with that of wild-type counterparts, a deficiency that is correlated with an exaggerated CD4 T cell:APC ratio in lymph nodes of muMT(-/-) NOD mice. This feature points to an insufficient availability of APC costimulation on a per T cell basis, resulting in impaired CD4 T cell activation in lymph nodes of muMT(-/-) NOD mice. In accordance with these findings, an islet-reactive CD4 T cell clonotype undergoes suboptimal activation in pancreatic lymph nodes of muMT(-/-) NOD recipients. Overall, the present study indicates that B cells in the pancreatic lymph node microenvironment are critical in overcoming a checkpoint involving the provision of optimal costimulation to islet-reactive NOD CD4 T cells." @default.
- W2114867586 created "2016-06-24" @default.
- W2114867586 creator A5015387207 @default.
- W2114867586 creator A5020184063 @default.
- W2114867586 creator A5020626435 @default.
- W2114867586 creator A5045651707 @default.
- W2114867586 creator A5050754705 @default.
- W2114867586 creator A5062228664 @default.
- W2114867586 creator A5072914980 @default.
- W2114867586 creator A5074811142 @default.
- W2114867586 creator A5078628909 @default.
- W2114867586 creator A5087837146 @default.
- W2114867586 date "2001-10-15" @default.
- W2114867586 modified "2023-10-03" @default.
- W2114867586 title "Impaired Activation of Islet-Reactive CD4 T Cells in Pancreatic Lymph Nodes of B Cell-Deficient Nonobese Diabetic Mice" @default.
- W2114867586 cites W1549435714 @default.
- W2114867586 cites W1586126658 @default.
- W2114867586 cites W1593117474 @default.
- W2114867586 cites W1598354195 @default.
- W2114867586 cites W1666706706 @default.
- W2114867586 cites W1903855848 @default.
- W2114867586 cites W1911119530 @default.
- W2114867586 cites W1978790143 @default.
- W2114867586 cites W2009531856 @default.
- W2114867586 cites W2012385634 @default.
- W2114867586 cites W2014964960 @default.
- W2114867586 cites W2020579022 @default.
- W2114867586 cites W2026754816 @default.
- W2114867586 cites W2062572904 @default.
- W2114867586 cites W2071756824 @default.
- W2114867586 cites W2081864087 @default.
- W2114867586 cites W2100599721 @default.
- W2114867586 cites W2113315096 @default.
- W2114867586 cites W2117139202 @default.
- W2114867586 cites W2120619443 @default.
- W2114867586 cites W2121789150 @default.
- W2114867586 cites W2124870236 @default.
- W2114867586 cites W2137504995 @default.
- W2114867586 cites W2148619935 @default.
- W2114867586 cites W2156422253 @default.
- W2114867586 cites W2157996727 @default.
- W2114867586 cites W2159433728 @default.
- W2114867586 cites W2164224003 @default.
- W2114867586 cites W2469343808 @default.
- W2114867586 cites W4236939167 @default.
- W2114867586 cites W4250302047 @default.
- W2114867586 cites W4255343140 @default.
- W2114867586 cites W4313348033 @default.
- W2114867586 doi "https://doi.org/10.4049/jimmunol.167.8.4351" @default.
- W2114867586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11591759" @default.
- W2114867586 hasPublicationYear "2001" @default.
- W2114867586 type Work @default.
- W2114867586 sameAs 2114867586 @default.
- W2114867586 citedByCount "71" @default.
- W2114867586 countsByYear W21148675862012 @default.
- W2114867586 countsByYear W21148675862013 @default.
- W2114867586 countsByYear W21148675862014 @default.
- W2114867586 countsByYear W21148675862015 @default.
- W2114867586 countsByYear W21148675862016 @default.
- W2114867586 countsByYear W21148675862017 @default.
- W2114867586 countsByYear W21148675862018 @default.
- W2114867586 countsByYear W21148675862019 @default.
- W2114867586 countsByYear W21148675862021 @default.
- W2114867586 countsByYear W21148675862022 @default.
- W2114867586 crossrefType "journal-article" @default.
- W2114867586 hasAuthorship W2114867586A5015387207 @default.
- W2114867586 hasAuthorship W2114867586A5020184063 @default.
- W2114867586 hasAuthorship W2114867586A5020626435 @default.
- W2114867586 hasAuthorship W2114867586A5045651707 @default.
- W2114867586 hasAuthorship W2114867586A5050754705 @default.
- W2114867586 hasAuthorship W2114867586A5062228664 @default.
- W2114867586 hasAuthorship W2114867586A5072914980 @default.
- W2114867586 hasAuthorship W2114867586A5074811142 @default.
- W2114867586 hasAuthorship W2114867586A5078628909 @default.
- W2114867586 hasAuthorship W2114867586A5087837146 @default.
- W2114867586 hasBestOaLocation W21148675861 @default.
- W2114867586 hasConcept C126322002 @default.
- W2114867586 hasConcept C134018914 @default.
- W2114867586 hasConcept C142724271 @default.
- W2114867586 hasConcept C154317977 @default.
- W2114867586 hasConcept C165220095 @default.
- W2114867586 hasConcept C202751555 @default.
- W2114867586 hasConcept C203014093 @default.
- W2114867586 hasConcept C2776090121 @default.
- W2114867586 hasConcept C2778013207 @default.
- W2114867586 hasConcept C2779720271 @default.
- W2114867586 hasConcept C2779855799 @default.
- W2114867586 hasConcept C2780849966 @default.
- W2114867586 hasConcept C55493867 @default.
- W2114867586 hasConcept C555293320 @default.
- W2114867586 hasConcept C55851684 @default.
- W2114867586 hasConcept C71924100 @default.
- W2114867586 hasConcept C86803240 @default.
- W2114867586 hasConcept C8891405 @default.
- W2114867586 hasConceptScore W2114867586C126322002 @default.
- W2114867586 hasConceptScore W2114867586C134018914 @default.
- W2114867586 hasConceptScore W2114867586C142724271 @default.
- W2114867586 hasConceptScore W2114867586C154317977 @default.