Matches in SemOpenAlex for { <https://semopenalex.org/work/W2114872207> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2114872207 endingPage "701" @default.
- W2114872207 startingPage "701" @default.
- W2114872207 abstract "Evidence suggests that sickle cell disease (SCD) is associated with a chronic inflammatory state. C-reactive protein (CRP) is known to modulate inflammation. Its role in the chronic inflammation of SCD may make it valuable as a therapeutic target.The aim was to determine CRP levels in SCD subjects in asymptomatic steady state (ASS) and crisis and correlate these with severity scores in the ASS.We measured the level of CRP in 30 hemoglobin SS (HbSS) individuals in ASS and seven in crisis. As controls, we measured CRP in 50 individuals each who were hemoglobin AS and hemoglobin AA respectively, using enzyme linked immunoabsorbent assay based commercially available kits from East Wing Diagnostic Limited Full blood count (white blood cell [WBC]) was done for the ASS HbSS individuals using a cell counter and their disease severity calculated by an objective scoring method.Our results showed that ASS HbSS individuals had significantly higher CRP levels compared with the controls. The HbSS individuals in crisis also had a significantly higher level of CRP compared to the ASS HbSS individuals. Disease severity and WBC were found to be negatively correlated with CRP levels (P = 0.17; and 0.73, respectively).Our results suggest that increased levels of CRP in ASS HbSS individuals may play a protective role in SCD leading to better disease outcome, and may have value as a therapeutic target." @default.
- W2114872207 created "2016-06-24" @default.
- W2114872207 creator A5048574257 @default.
- W2114872207 creator A5048959824 @default.
- W2114872207 creator A5065348869 @default.
- W2114872207 creator A5066519675 @default.
- W2114872207 creator A5087448745 @default.
- W2114872207 creator A5087656410 @default.
- W2114872207 date "2014-01-01" @default.
- W2114872207 modified "2023-10-11" @default.
- W2114872207 title "C-reactive protein and disease outcome in Nigerian sickle cell disease patients" @default.
- W2114872207 cites W1892847006 @default.
- W2114872207 cites W1966311619 @default.
- W2114872207 cites W1998514659 @default.
- W2114872207 cites W2003992777 @default.
- W2114872207 cites W2019381418 @default.
- W2114872207 cites W2024241294 @default.
- W2114872207 cites W2029354019 @default.
- W2114872207 cites W2033392675 @default.
- W2114872207 cites W2048820411 @default.
- W2114872207 cites W2049292864 @default.
- W2114872207 cites W2049638212 @default.
- W2114872207 cites W2062371885 @default.
- W2114872207 cites W2081615427 @default.
- W2114872207 cites W2127365004 @default.
- W2114872207 cites W2143013475 @default.
- W2114872207 cites W2143582911 @default.
- W2114872207 doi "https://doi.org/10.4103/2141-9248.141523" @default.
- W2114872207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4199159" @default.
- W2114872207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25328778" @default.
- W2114872207 hasPublicationYear "2014" @default.
- W2114872207 type Work @default.
- W2114872207 sameAs 2114872207 @default.
- W2114872207 citedByCount "16" @default.
- W2114872207 countsByYear W21148722072015 @default.
- W2114872207 countsByYear W21148722072016 @default.
- W2114872207 countsByYear W21148722072017 @default.
- W2114872207 countsByYear W21148722072018 @default.
- W2114872207 countsByYear W21148722072019 @default.
- W2114872207 countsByYear W21148722072020 @default.
- W2114872207 countsByYear W21148722072022 @default.
- W2114872207 countsByYear W21148722072023 @default.
- W2114872207 crossrefType "journal-article" @default.
- W2114872207 hasAuthorship W2114872207A5048574257 @default.
- W2114872207 hasAuthorship W2114872207A5048959824 @default.
- W2114872207 hasAuthorship W2114872207A5065348869 @default.
- W2114872207 hasAuthorship W2114872207A5066519675 @default.
- W2114872207 hasAuthorship W2114872207A5087448745 @default.
- W2114872207 hasAuthorship W2114872207A5087656410 @default.
- W2114872207 hasBestOaLocation W21148722072 @default.
- W2114872207 hasConcept C126322002 @default.
- W2114872207 hasConcept C203014093 @default.
- W2114872207 hasConcept C2776914184 @default.
- W2114872207 hasConcept C2777910003 @default.
- W2114872207 hasConcept C2778488018 @default.
- W2114872207 hasConcept C2778917026 @default.
- W2114872207 hasConcept C2779134260 @default.
- W2114872207 hasConcept C2781195455 @default.
- W2114872207 hasConcept C71924100 @default.
- W2114872207 hasConcept C90924648 @default.
- W2114872207 hasConceptScore W2114872207C126322002 @default.
- W2114872207 hasConceptScore W2114872207C203014093 @default.
- W2114872207 hasConceptScore W2114872207C2776914184 @default.
- W2114872207 hasConceptScore W2114872207C2777910003 @default.
- W2114872207 hasConceptScore W2114872207C2778488018 @default.
- W2114872207 hasConceptScore W2114872207C2778917026 @default.
- W2114872207 hasConceptScore W2114872207C2779134260 @default.
- W2114872207 hasConceptScore W2114872207C2781195455 @default.
- W2114872207 hasConceptScore W2114872207C71924100 @default.
- W2114872207 hasConceptScore W2114872207C90924648 @default.
- W2114872207 hasIssue "5" @default.
- W2114872207 hasLocation W21148722071 @default.
- W2114872207 hasLocation W21148722072 @default.
- W2114872207 hasLocation W21148722073 @default.
- W2114872207 hasLocation W21148722074 @default.
- W2114872207 hasOpenAccess W2114872207 @default.
- W2114872207 hasPrimaryLocation W21148722071 @default.
- W2114872207 hasRelatedWork W1988345744 @default.
- W2114872207 hasRelatedWork W1995188757 @default.
- W2114872207 hasRelatedWork W2110359579 @default.
- W2114872207 hasRelatedWork W2116001782 @default.
- W2114872207 hasRelatedWork W2349295819 @default.
- W2114872207 hasRelatedWork W2364362829 @default.
- W2114872207 hasRelatedWork W2396977215 @default.
- W2114872207 hasRelatedWork W2792399673 @default.
- W2114872207 hasRelatedWork W3193652918 @default.
- W2114872207 hasRelatedWork W4229900919 @default.
- W2114872207 hasVolume "4" @default.
- W2114872207 isParatext "false" @default.
- W2114872207 isRetracted "false" @default.
- W2114872207 magId "2114872207" @default.
- W2114872207 workType "article" @default.