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- W2114873535 abstract "Programmed cell death is important for the proper development of the retina, and microRNAs (miRNAs) may be critical for its regulation. Here, we report that miR-24a is expressed in the neural retina and is required for correct eye morphogenesis in Xenopus. Inhibition of miR-24a during development causes a reduction in eye size due to a significant increase in apoptosis in the retina, whereas overexpression of miR-24a is sufficient to prevent apoptosis. We show that miR-24a negatively regulates the proapoptotic factors caspase9 and apaf1, demonstrating a role for miRNAs in the regulation of apoptosis during normal development." @default.
- W2114873535 created "2016-06-24" @default.
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- W2114873535 date "2009-07-01" @default.
- W2114873535 modified "2023-09-29" @default.
- W2114873535 title "microRNA-24a is required to repress apoptosis in the developing neural retina" @default.
- W2114873535 doi "https://doi.org/10.1016/j.ydbio.2009.05.197" @default.
- W2114873535 hasPublicationYear "2009" @default.
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