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- W2114886688 abstract "Thioredoxin reductase (TRR1) is an important component of the thioredoxin oxidative stress resistance pathway. Here we show that it is induced during oxidative and nitrosative stress and is preferentially localized to the mitochondria in Cryptococcus neoformans. The C. neoformans TRR1 gene encodes the low-molecular-weight isoform of the thioredoxin reductase enzyme, which shares little homology with that of its mammalian host. By replacing the endogenous TRR1 promoter with an inducible copper transporter promoter, we showed that Trr1 appears to be essential for viability of this pathogenic fungus, making it a potential antifungal target." @default.
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- W2114886688 date "2005-02-01" @default.
- W2114886688 modified "2023-09-23" @default.
- W2114886688 title "Thioredoxin Reductase Is Essential for Viability in the Fungal Pathogen <i>Cryptococcus neoformans</i>" @default.
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- W2114886688 doi "https://doi.org/10.1128/ec.4.2.487-489.2005" @default.
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